| HPLC | high-performance liquid chromatography; high-power liquid chromatography; high-pressure liquid chrom... |
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| CLD | chloride diarrhea; chronic liver disease; chronic lung disease; congenital limb deficiency; crystal ... |
| MLC | minimum lethal concentration; mixed leukocyte culture; mixed ligand chelate; mixed lymphocyte concen... |
| MLCT | metal-to-ligand charge transfer |
| CCCC | centrifugal countercurrent chromatography |
| RP-HPLC | chromatography and reversed-phase high-performance liquid chromatography |
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| APO2L | AP02 ligand |
| CD30L | CD30 ligand |
| CD40L | CD40 Ligand |
| CD40L | CD40-CD40 ligand |
| ambident ligand | <chemistry> A ligand that can donate electrons through two or more atoms on their molecule. (05 Feb 1998) |
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| cyanocobalamin beta-ligand transferase | <enzyme> Cytosolic enzyme utilizing fad, NADPH and reduced glutathione; forms glutathionylcobalamin from cyanocobalamin Registry number: EC 2.5.1.- Synonym: ccbl transferase (26 Jun 1999) |
| ELAM-1 ligand fucosyltransferase | <enzyme> Directs the expression of an elam-1 ligand; an alpha(1,3) fucosyltransferase Registry number: EC 2.4.1.- Synonym: elft protein, elft gene product (26 Jun 1999) |
| ligand | <chemistry, immunology> Any molecule that binds to another, in normal usage a soluble molecule such as a hormone or neurotransmitter, that binds to a receptor. The decision as to which is the ligand and which the receptor is often a little arbitrary when the broader sense of receptor is used (where there is no implication of transduction of signal). In these cases it is probably a good rule to consider the ligand to be the smaller of the two thus in a lectin sugar interaction, the sugar would be the ligand (even though it is attached to a much larger molecule, recognition is of the saccharide). (18 Nov 1997) |
| ligand binding site | The site on a protein's surface that binds a ligand; equivalent to the active site if the ligand is the substrate of an enzyme. (05 Mar 2000) |
| ligand-gated channel | A class of ion channel's whose ionic permeability is regulated by cell membrane receptors that respond to specific extracellular chemical signals. (05 Mar 2000) |
| ligand gated ion channel | A transmembrane ion channel whose permeability is increased by the binding of a specific ligand, typically a neurotransmitter at a chemical synapse. The permeability change is often drastic, such channels let through effectively no ions when shut, but allow passage at up to 10exp7 ions sexp 1 when a ligand is bound. Recently, the receptors for both acetylcholine and GABA have been found to share considerable sequence homology, implying that there may be a family of structurally related ligand gated ion channels. (18 Nov 1997) |
| ligand induced endocytosis | The formation of coated pits and then coated vesicles as a consequence of the interaction of ligand with receptors, which then interact with clathrin and associated proteins (coatomers) on the cytoplasmic face of the plasma membrane and come together to form a pit. Not all coated vesicle uptake of receptors requires receptor occupancy. (18 Nov 1997) |
| absorption chromatography | <investigation> Techniques for separating molecules based on differential absorption and elution. Term for separation methods involving flow of a fluid carrier over a nonmobile absorbing phase. (18 Nov 1997) |
| adsorption chromatography | Chromatography in which separation of substances is achieved by the difference in degree of adsorption of the compounds to a stationary phase. (05 Mar 2000) |
| affinity chromatography | <investigation> A technique of analytical chemistry used to separate and purify a biological molecule from a mixture, based on the attraction of the molecule of interest to a particular ligand which has been previously attached to a solid, inert substance. The mixture is passed through a column containing the ligand attached to the stationary substance, so that the molecule of interest stays within the column while the rest of the mixture continues through to the end. Then, a different chemical is flushed through the column to detach the molecule from the ligand and bring it out separately from the rest of the mixture. (09 Feb 1998) |
| gas chromatography | <technique> A chromatographic technique (a type of column chromatography) in which the stationary phase is solid while the mobile phase is gaseous samples. The gaseous samples are separated based on their different adsorption ability to the solid phase. (09 Oct 1997) |
| gas-liquid chromatography | <technique> A chemistry lab technique, a type of column chromatography, used to separate the components of a mixed substance. The substance is held stationary by an inert solid coated with an inert liquid which is not likely to evaporate (i.e. Is nonvolatile), while a gas (called an eluant) flows past it bringing out the components one at a time. (09 Oct 1997) |
| paper chromatography | <technique> Separation method in which filter paper is used as the support. A type of chromatography in which the stationary phase is a sheet of special-grade filter paper. It is in all other aspects similar to thin-layer chromatography. Not a very sensitive method, but historically important as one of the first methods available for separating natural compounds. (07 Mar 2000) |
| gel exclusion chromatography | <investigation> A lab technique, a type of column chromatography, used to separate the components of a mixture by molecular size and to collect the molecules which are larger than a certain size. It is similar to gel filtration, small molecules are slowed or trapped by the pores in the gel beads filling the column, while large molecules, too large to fit into the pores, slide past the beads and get to the bottom of the column first. at this point, the large molecules are collected. Gel exclusion refers to the maximum size of molecule which will fit into the gel bead pores, and this lab technique is used to collect the molecules in the mixture which are larger than, or excluded from, the pores. (09 Oct 1997) |
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