| GAWTS | genomic amplification with transcript sequencing |
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| gDNA | genomic deoxyribonucleic acid |
| AAHSLD | Association of Academic Health Sciences Library Directors |
| ANSWER | Agency for Toxic Substances and Disease Registry/National Library of Medicine's Workstation for Emer... |
| BLLD | British Library Lending Division |
| MLA | Medical Library Association |
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| CGH | Comparative Genomic Hybridisation |
| gDNA | Genomic DNA |
| GISH | Genomic in situ hybridization |
| RLGS | Restriction Landmark Genomic Scanning |
| library, genomic | A collection of DNA clones made from a set of randomly generated overlapping DNA fragments representing the entire genome of an organism. As a molecular genetic sequel to john steinbeck's of mice and men , today you can have a mouse genomic library or a human genomic library. (12 Dec 1998) |
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| genomic library | <molecular biology> A collection of DNA molecules, derived from restriction fragments that have been cloned in vectors, that includes all or part of the genetic material of an organism. (18 Nov 1997) |
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| genomic | Relating to a genome. (05 Mar 2000) |
| genomic DNA | <molecular biology> The DNA which is found in the organisms genome and is passed on to offspring as information necessary for survival. The phrase is used to distinguish between other types of DNA, such as found within plasmids. (09 Oct 1997) |
| genomic formula | <molecular biology> The method used to identify the number of sets of chromosomes within a cell or organism (i.e. Its ploidy). Each set is designated n so one set is n is haploid, two sets is 2n is diploid, three sets is 3n is triploid, four sets is 4n is tetraploid, etc. Also, 2n+1 is known as trisomy (i.e. Two full sets plus a third copy of one of the chromosomes). (09 Oct 1997) |
| genomic imprinting | <genetics, molecular biology> Parent specific expression or repression of genes or chromosomes in offspring. There are an increasing number of recognised chromosomal imprinting events in pathological conditions: for example preferential transmission of paternal or maternal predisposition to diabetes or atopy, preferential retention of paternal alleles in rhabdomyosarcoma, osteosarcoma, retinoblastoma and Wilm's tumour, preferential translocation to the paternal chromosome 9 of a portion of maternal chromosome 22 to form the Philadelphia chromosome of chronic myeloid leukaemia. (18 Nov 1997) |
| arrayed library | <molecular biology> Individual primary recombinant clones (hosted in phage, cosmid, YAC, or other vector) that are placed in two-dimensional arrays in microtiter dishes. Each primary clone can be identified by the identity of the plate and the clone location (row and column) on that plate. Arrayed libraries of clones can be used for many applications, including screening for a specific gene or genomic region of interest as well as for physical mapping. Information gathered on individual clones from various genetic linkage and physical map analyses is entered into a relational database and used to construct physical and genetic linkage maps simultaneously, clone identifiers serve to interrelate the multilevel maps. Compare: library, genomic library. (19 Jan 1998) |
| gene library | <molecular biology> A collection of cloned DNA fragments that contains all the genetic information of a particular organism. (09 Oct 1997) |
| cDNA library | <molecular biology> A collection of all of the mRNA molecules present in a cell or organism, all turned into cDNA molecules with the enzyme reverse transcriptase, then inserted into vectors (other DNA molecules which can continue to replicate after addition of foreign DNA). The library can then be probed for the specific cDNA (and thus mRNA) of interest. (09 Oct 1997) |
| peptide library | A collection of cloned free peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide. (12 Dec 1998) |
| complementary DNA library | <molecular biology> A collection of all of the mRNA molecules present in a cell or organism, all turned into cDNA molecules with the enzyme reverse transcriptase, then inserted into vectors (other DNA molecules which can continue to replicate after addition of foreign DNA). The library can then be probed for the specific cDNA (and thus mRNA) of interest. (09 Oct 1997) |
| national library of medicine | An agency of the national institutes of health concerned with overall planning, promoting, and administering programs pertaining to various aspects of documentation and library services in the field of medicine. (12 Dec 1998) |
| DNA library | <molecular biology> A collection of DNA molecules, derived from restriction fragments that have been cloned in vectors, that includes all or part of the genetic material of an organism. (18 Nov 1997) |
| epitope library | <molecular biology> Large collection (hundreds of millions) of peptides each encoded by a randomly mutated piece of DNA in a phage genome and expressed on the surface of that bacteriophage, sometimes as an N terminal extension of a coat protein. Particular phages can be selected by a binding assay and since the peptide has its encoding DNA associated with it sequencing is straightforward. (18 Nov 1997) |
| expression library | <molecular biology> A library of DNA fragments which was created with an expression vector so that any genes present in the library are expressed. (09 Oct 1997) |
| library | <molecular biology> A collection of DNA molecules, derived from restriction fragments that have been cloned in vectors, that includes all or part of the genetic material of an organism. (18 Nov 1997) |
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