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| MELAS Syndrome | 1. Mitochondrial Encephalomyopathy 2. Lactic Acidosis 3. S... |
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| MELAS | mitochondrial encephalomyopathy-lactic acidosis- and stroke-like symptoms [syndrome] |
| MERRLA | myoclonus epilepsy-ragged red fibers-lactic acidosis [syndrome] |
| Acid. | Acidosis |
| DKA | Diabetic Keto-Acidosis |
| MELAS | Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like episodes |
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| MELAS | Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes |
| LAT | lactic acidosis threshold |
| MELAS | myopathy, encephalopathy, lactic acidosis and stroke like episodes |
| CMA | Chronic metabolic acidosis |
| lactic acidosis | <biochemistry, physiology> Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolised. It may occur spontaneously or in association with diseases such as diabetes mellitus, leukaemia, or liver failure. (25 Jun 1999) |
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| lactic | <physiology> Of or pertaining to milk; procured from sour milk or whey; as, lactic acid; lactic fermentation, etc. <biochemistry, physiology> Lactic acid, a sirupy, colourless fluid, soluble in water, with an intensely sour taste and strong acid reaction. There are at least three isomeric modifications all having the formula C3H6O3. Sarcolactic or paralactic acid occurs chiefly in dead muscle tissue, while ordinary lactic acid results from fermentation. The two acids are alike in having the same constitution (expressed by the name ethylidene lactic acid), but the latter is optically inactive, while sarcolactic acid rotates the plane of polarization to the right. The third acid, ethylene lactic acid, accompanies sarcolactic acid in the juice of flesh, and is optically inactive. Lactic ferment, an organised ferment (Bacterium lacticum or lactis), which produces lactic fermentation, decomposing the sugar of milk into carbonic and lactic acids, the latter, of which renders the milk sour, and precipitates the casein, thus giving rise to the so-called spontaneous coagulation of milk. Lactic fermentation. See Fermentation. Origin: L. Lac, lactis, milk: cf. F. Lactique. See Lacteal, and cf. Galactic. Source: Websters Dictionary (01 Mar 1998) |
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| lactic acid | A byproduct of carbohydrate metabolism (anaerobic metabolism). A lactic acid level may be measured in the bloodstream in conditions of metabolic acidosis. Lactic acid is an intermediate product of carbohydrate metabolism and is derived mainly from muscle cells and red blood cells. Exercise will normally raise lactic acid levels. Conditions of oxygen deprivation (for example shock, heart failure, lung disease) will trigger anaerobic metabolism within muscle tissue resulting in lactic acid build up in the tissues. Normal lactic acid levels are 4.5 to 19.8 mg/dl. (25 Jun 1999) |
| lactic acid bacillus | A member of the genus Lactobacillus. (05 Mar 2000) |
| lactic acid bacteria | <microbiology> A group of Gram-positive, non-sporing bacteria which carry out a lactic acid fermentation of sugars. It includes species of Lactobacillus, Leuconostoc, Pediococcus and Streptococcus. See: lactic acid fermentation. (25 Jun 1999) |
| lactic acid dehydrogenase | <enzyme> An enzyme with 5 forms: LDH-1 is in the heart, its blood level can rise when heart muscle is damaged. Other forms can be found in the liver, brain, kidney, skeletal muscle and bone. A useful blood test in the evaluation of many disease processes, including heart attack, liver disease, muscular dystrophy and bone disease. (27 Sep 1997) |
| lactic acidemia | The presence of dextrorotatory lactic acid in the circulating blood. Synonym: lactacidemia. Origin: Lactic acid + G. Haima, blood (05 Mar 2000) |
| lactic acid fermentation | <biochemistry> A type of fermentation carried out by lactic acid bacteria in which sugar (for example lactose, glucose, pentose) are converted either entirely (or almost entirely) to lactic acid (homolactic fermentation) or to a mixture of lactic acid and other products (heterolactic fermentation). (09 Oct 1997) |
| lactic acid level | <investigation> A test that measures the amount of lactic acid in the blood. (25 Jun 1999) |
| lactic acid oxidative decarboxylase | A flavoprotein oxidoreductase catalyzing oxidation (with O2) of l-lactate to acetate plus CO2 and water. Synonym: lactic acid oxidative decarboxylase. (05 Mar 2000) |
| lactic dehydrogenase | <enzyme> The enzyme that catalyses the formation and removal of lactate according to the equation: pyruvate + NADH = lactate NAD. <cell culture> The appearance of lactic dehydrogenase in the medium is often usedas an indication of cell death and the release of cytoplasmic constituents. Acronym: LDH (25 Jun 1999) |
| acidosis | <biochemistry> A metabolic condition, characterised by an increase in hydrogen ion concentration, that occurs when the body is no longer able to buffer free hydrogen ions in the blood, resluting from either the accumulation of acid or depletion of the alkaline reserve (bicarbonate) in the blood and body tissues. This usually causes the pH of the blood to drop (and become more acidic). Compare: alkalosis. (10 May 1997) |
| carbon dioxide acidosis | <biochemistry> A metabolic derangement of acid-base balance where the blood pH is abnormally low. Causes include haemorrhagic shock, cardiogenic shock, severe dehydration, sepsis, toxic ingestion (for example isopropyl alcohol, methanol), alcoholic ketoacidosis, lactic acidosis, renal failure and diabetic ketoacidosis. Respiratory acidosis will occur if the lungs are not ventilating properly resulting in an excess of carbon dioxide in the body. (25 Jun 1999) |
| renal tubular acidosis | <nephrology> A rare sometimes familial disorder of the renal tubule characterised by the inability to excrete urine of normal acidity. This leads to a hyperchloraemic acidosis which is often associated with one or more secondary complications such as hypercalcinuria with nephrolithiasis and nephrocalcinosis, rickets, or osteomalacia and severe potassium depletion. (25 Jun 1999) |
| respiratory acidosis | <biochemistry> A metabolic derangement of acid-base balance where the blood pH is abnormally low. Causes include haemorrhagic shock, cardiogenic shock, severe dehydration, sepsis, toxic ingestion (for example isopropyl alcohol, methanol), alcoholic ketoacidosis, lactic acidosis, renal failure and diabetic ketoacidosis. Respiratory acidosis will occur if the lungs are not ventilating properly resulting in an excess of carbon dioxide in the body. (25 Jun 1999) |
| metabolic acidosis | <biochemistry> A metabolic derangement of acid-base balance where the blood pH is abnormally low. Causes include haemorrhagic shock, cardiogenic shock, severe dehydration, sepsis, toxic ingestion (for example isopropyl alcohol, methanol), alcoholic ketoacidosis, lactic acidosis, renal failure and diabetic ketoacidosis. Respiratory acidosis will occur if the lungs are not ventilating properly. (27 Jun 1999) |
| lactic acidosis |
High levels of lactic acid in the blood, which is potentially fatal. Symptoms include nausea, vomiting, fatigue, and shortness of breath. The use of nucleoside analogs can contribute to lactic acidosis.
Ãâó: www.amfar.org/cgi-bin/iowa/bridge.html
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| lactic acidosis |
a rare but deadly metabolic disorder. Symptoms can include weight loss, fatigue, malaise, nausea, vomiting, abdominal pain, shortness of breath and low SERUM bicarbonate levels. NUCLEOSIDE ANALOGS have been associated with mitochondrial toxicity, which can lead to lactic acidosis.
Ãâó: www.gmhc.org/health/glossary3.html
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| lactic acidosis |
a serious condition caused by the build up of lactic acid which is produced from glucose when there is not enough oxygen. Similar effects as ketoacidosis
Ãâó: www.diabetes.org.au/glossary.htm
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| lactic acidosis |
An accumulation of toxic levels of lactate in the blood that can result in loss of consciousness; can occur during biguanide therapy.
Ãâó: www.gsk.co.nz/avandia/glossary/index.asp
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