| HMWK | high-molecular-weight kininogen |
|---|---|
| Kgn | kininogen |
| KNG | kininogen |
| HMWK | High molecular weight kininogen |
|---|---|
| HK | high-molecular-weight kininogen |
| LMWK | low molecular weight kininogen |
| HK | weight kininogen |
| kininogen | <biochemistry> Inactive precursor in plasma from which kinin is produced by proteolytic cleavage. (18 Nov 1997) |
|---|---|
| kininogen, high-molecular-weight | A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with prekallikrein. Hmwk is split by plasma kallikrein to produce bradykinin. The complex is a cofactor in the activation of coagulation factor xii. The product of this reaction, xiia, in turn activates prekallikrein to kallikrein. (12 Dec 1998) |
| kininogen, low-molecular-weight | A protein, molecular weight 50 kD, located in various normal tissues. Upon cleavage by kallikrein or other kallikreins, it forms kallidin. Kallidin, in turn, is converted into bradykinin. (12 Dec 1998) |
| kininogenase | <protein> Plasma serine proteases normally present as inactive prekallikreins which are activated by Hageman factor. Act on kininogens to produce kinins. Contain an apple domain. (18 Nov 1997) |
| kininogenin | <protein> Plasma serine proteases normally present as inactive prekallikreins which are activated by Hageman factor. Act on kininogens to produce kinins. Contain an apple domain. (18 Nov 1997) |
| kininogens | <chemical> Endogenous peptides present in most body fluids. Certain enzymes convert them to active kinins which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. High-molecular-weight kininogen (hmwk) is split by plasma kallikrein to produce bradykinin. Low-molecular-weight kininogen (lmwk) is split by tissue kallikrein to produce kallidin. Pharmacological action: cysteine proteinase inhibitors. (12 Dec 1998) |
Synonyms : Fitzgerald Factor, HMWK, High Molecular Weight Kininogen, High Molecular Weight Kininogens, High-Molecular-Weight Kininogens, Kininogens, High Molecular Weight, Kininogen, High Molecular Weight, Kininogens, High-Molecular-Weight
Synonyms : LMWK, Low Molecular Weight Kininogen, Low Molecular Weight Kininogens, Low-Molecular-Weight Kininogens, Kininogen, Low Molecular Weight, Kininogens, Low-Molecular-Weight
Synonyms : Kininogen, Prekinins, Prokinins, T-Kininogen, Thiostatin, Kininogen Cystatins, T Kininogen
| kininogen |
either of two plasma α2-globulins that are kinin precursors, called high-molecular-weight k. and low-molecular-weight k.
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