| LAK T cells | Lymphokine Activated Killer T cells |
|---|---|
| NK cell | Natural Killer cell |
| AAK | allo-activated killer |
| A-LAK | adherent lymphokine-activated killer [cell] |
| KAF | conglutinogen-activating factor; killer-assisting factor; kinase activating factor |
| Y | Yeast |
|---|---|
| YAC | Yeast Artificial Chromosome |
| YNB | Yeast Nitrogen Base |
| YES | Yeast extract sucrose |
| BCYE | buffered charcoal yeast extract |
| killer yeast | <microbiology> A yeast that secretes a toxin that can kill other yeasts. (09 Oct 1997) |
|---|
| monocytes, activated killer | Monocytes made cytotoxic by ex vivo incubation with cytokines, especially interferon-gamma. Akm cells are used for adoptive immunotherapy in cancer patients. (12 Dec 1998) |
|---|---|
| natural killer cell | <haematology, immunology> A certain type of white blood cell that attacks tumour cells and infected body cells by binding to a tumour cell and releasing lethal chemicals. Natural killer cells are thought to play a key role in cancer prevention by killing abnormal cells before they multiply and grow. (16 Dec 1997) |
| natural killer cells | Large granular lymphocytes which do not express markers of either T or B-cell lineage. These cells do possess Fc receptors for IgG and can kill target cells using antibody-dependent cell-mediated cytotoxicity. NK cells can also use perforin to kill cells in the absence of antibody. Killing may occur without previous sensitization. Synonym: NK cells. (05 Mar 2000) |
| natural killer cell stimulating factor | <cytokine> A 75 kD heterodimeric cytokine composed of disulfide-bonded 40 kD and 35 kD subunits that was originally identified by its ability to induce cytotoxic effector cells in synergy with less than optimal concentrations of interleukin-2. It is released by macrophages in response to infection and promotes the activation of cell-mediated immunity. Specifically, IL-12 triggers the maturation of Thl CD4 cells, specific cytotoxic T-lymphocyte responses and an increase in the activity of NK cells and consequently, it is the initiator of cell-mediated immunity. It enhances the lytic activity of NK cells, induces interferon production, stimulates the proliferation of activated T-cells and NK cells. Is secreted by human B lymphoblastoid cells (NC 37). May play a role in controlling immunoglobulin isotype selection as it also inhibits IgE synthesis (even in the presence of anti-IFN monoclonal antibody) and as a growth factor for activated CD4+ and CD8+ T-cells independently of interleukin-2, and for CD56+ NK cells but not resting peripheral blood mononuclear cells or resting or activated tonsillar B-cells. It is likely that interleukin 12 has a major role in protective immunity against viruses and is under study as an immunotherapy in HIV infection. Formerly referred to as cytotoxic lymphocyte maturation factor. Acronym: IL-12 (12 Dec 1998) |
| nine-killer | <zoology> The northern butcher bird. Origin: So called because it is believed to kill and impale on thorns nine birds, etc, in succession. Source: Websters Dictionary (01 Mar 1998) |
| killer | 1. One who deprives of life; one who, or that which, kills. 2. <zoology> A voracious, toothed whale of the genus Orca, of which several species are known. The killers have a high dorsal fin, and powerful jaws armed with large, sharp teeth. They capture, and swallow entire, large numbers of seals, porpoises, and dolphins, and are celebrated for their savage, combined attacks upon the right whales, which they are said to mutilate and kill. The common Atlantic species (Orca gladiator), is found both on the European and the American coast. Two species (Orca ater and O. Rectipinna) occur on the Pacific coast. Source: Websters Dictionary (01 Mar 1998) |
| killer cell | 1. <immunology> Mammalian cells which can lyse antibody coated target cells. They have a receptor for the Fc portion of IgG and are probably of the mononuclear phagocyte lineage, though some may be lymphocytes. Not to be confused with cytotoxic T-cells which recognise targets by other means and are clearly a sub set of T lymphocytes. This confusion exists in the early literature. 2. Natural killer cell are CD3 negative large granular lymphocytes, mediating cytolytic reactions that do not require expression of Class I or II major histocompatibility antigens on the target cell. 3. Lymphokine activated killer cells are NK cells activated by interleukin-2 (LAK cells). (13 Nov 1997) |
| killer cells | Lymphocyte-like effector cells which mediate antibody-dependent cell cytotoxicity. They kill antibody-coated target cells which they bind with their fc receptors. (12 Dec 1998) |
| killer cells, lymphokine-activated | Cytolytic lymphocytes with the unique capacity of killing natural killer (nk)-resistant fresh tumour cells. They are interleukin-2-activated nk cells that have no MHC (major histocompatibility complex) restriction or need for antigen stimulation. Lak cells are used for adoptive immunotherapy in cancer patients. (12 Dec 1998) |
| killer cells, natural | Cells responsible for spontaneous cytotoxicity of a variety of tumour cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as killer cells (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody. (12 Dec 1998) |
| killer plasmid | <molecular biology> These plasmids are found in some strains of Kluyveromyces marxianus where the cells contain multiple cytoplasmic copies of dsDNA plasmids. Such cells secrete a glycoprotein toxin. The plasmids and the killer function can be transferred to yeast. (18 Nov 1997) |
| killer T-cell | 1. <immunology> Mammalian cells which can lyse antibody coated target cells. They have a receptor for the Fc portion of IgG and are probably of the mononuclear phagocyte lineage, though some may be lymphocytes. Not to be confused with cytotoxic T-cells which recognise targets by other means and are clearly a sub set of T lymphocytes. This confusion exists in the early literature. 2. Natural killer cell are CD3 negative large granular lymphocytes, mediating cytolytic reactions that do not require expression of Class I or II major histocompatibility antigens on the target cell. 3. Lymphokine activated killer cells are NK cells activated by interleukin-2 (LAK cells). (13 Nov 1997) |
| lady-killer | A gallant who captivates the hearts of women. "A renowned dandy and lady-killer." Source: Websters Dictionary (01 Mar 1998) |
| brewers' yeast | Yeast produced by Saccharomyces cerevisiae; a by-product from the brewing of beer. (05 Mar 2000) |
| chromosomes, yeast artificial | Chromosomes in which fragments of exogenous DNA ranging in length up to several hundred kilobase pairs have been cloned into yeast through ligation to vector sequences. These artificial chromosomes are used extensively in molecular biology for the construction of comprehensive genomic libraries of higher organisms. (12 Dec 1998) |
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