| isotype switching | <immunology> The switch of immunoglobulin isotype that occurs, for example: as the immune response progresses (IgM to IgG). The switch from IgM to IgG involves only the constant region of the heavy chains (from _ to _), the light chain and variable regions of the heavy chain remaining the same and involves the switch regions, upstream (on the 5'side) of the constant region genes, at which recombination occurs. Similarly, IgM and IgD with the same variable region of the heavy chain, but with different heavy chain constant regions (_ and _), seem to coexist on the surface of some lymphocytes. (18 Nov 1997) |
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| isotype | 1. <immunology> Applied to a set of macromolecules sharing some features in common. In immunology isotype describes the class, subclass, light chain type and subtype of an immunoglobulin. 2. Antigenic determinant that is uniquely present in individuals of a single species. 3. <statistics> A conventionalised method for the graphical display of statistical data. (18 Nov 1997) |
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| antigenic switching | <immunology> The process by which a pathogenic microbe's genetic structure is altered tochange its surface antigens inorder to avoid being detected by the host's immune system. (09 Oct 1997) |
| magnetic switching | <radiobiology> The use as switches of saturable inductors for producing high power pulses without electrical arcs. This is a principal technology for extending single-shot accelerators in light-ion-beam-driven inertial confinement fusion to repetitively pulsed devices for possible reactors. Three terawatt, 200 KJ magnetic switches have been developed for fusion drivers at Sandia National Laboratories. (Info from the 1985 OSTI Glossary of Fusion Energy, may be out of date.) (09 Oct 1997) |
| switching | 1. Making a shift or exchange. 2. The movement of a defined region of DNA within a genome. Class switching, a change in the expression of the C region of an immunoglobulin heavy chain. (05 Mar 2000) |
| switching site | The break point in a DNA sequence at which a gene segment unites with another gene segment, as in the production of the immunoglobulins. (05 Mar 2000) |
| immunoglobulin class switching | Gene rearrangement of the b-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing. (12 Dec 1998) |
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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