| ¿µ¹® | isotope | ÇÑ±Û | µ¿À§¿ø¼Ò |
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| ¼³¸í | ¿øÀÚ¹øÈ£´Â °°Áö¸¸ Áú·® ¼ö°¡ ´Ù¸¥ ¿ø¼Ò. µ¿À§Ã¼¶ó°íµµ ÇÑ´Ù. Isotope¶ó´Â ¸íĪÀº F. ¼Òµð°¡ ¸í¸íÇÑ °ÍÀÌ´Ù. µ¿À§¿ø¼Ò´Â º¸Åë¿ø¼Ò±âÈ£ÀÇ ¿ÞÂÊ ¾î±ú¿¡ Áú·®¼ö¸¦ ºÙ¿© Ç¥½ÃÇÑ´Ù. ÀϹÝÀûÀ¸·Î µ¿À§¿ø¼Ò´Â ¼ºÁúÀÌ ºñ½ÁÇÏÁö¸¸ ¿øÀÚ¹øÈ£°¡ ÀÛÀº ¿ø¼Ò, ¿¹¸¦ µé¾î ¼ö¼ÒÀÇ µ¿À§¿ø¼Ò(¼ö¼Ò 1H, Áß¼ö¼Ò 2H, 3Áß¼ö¼Ò 3H) µî¿¡¼´Â ÈÇÐÀû ¼ºÁú±îÁöµµ ¾à°£ ´Ù¸¥µ¥°¡ ÀÖ´Ù. µ¿À§¿ø¼Ò¿¡´Â ¾ÈÁ¤ÇÑ µ¿À§¿ø¼Ò¿Í ºÒ¾ÈÁ¤ÇÑ ¹æ»ç¼ºµ¿À§¿ø¼Ò°¡ ÀÖ´Ù. |
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| ¿µ¹® | clearance | ÇÑ±Û | û¼Ò |
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| ¼³¸í | ´ÜÀ§½Ã°£¿¡ ¾î¶² ¹°ÁúÀÌ ºÐºñ±â°üÀ» ÅëÇÏ¿© Ç÷¾×¿¡¼ Á¦°ÅµÇ´Â Çö»ó ȤÀº Á¦°ÅÇÒ ¼ö ÀÖ´Â ´É·Â. Ä¡°ú¿ë¾î·Î´Â Áö´ëÄ¡ Çü¼ºµÈ Ä¡¾ÆÀÇ ±³ÇÕ¸é°ú ´ëÇÕÄ¡ ±³ÇÕ¸é°úÀÇ °Å¸® ¶Ç´Â ´ëÇÕÄ¡ ±³Çո鰣ÀÇ °Å¸®¸¦ ÁÖ·Î ³ªÅ¸³»°í, ±âŸ ¼·Î ¸¶ÁÖº¸°í ÀÖ´Â ¹°Ã¼°£ÀÇ °Å¸®¸¦ ³ªÅ¸³¾ °æ¿ì¿¡µµ Àû¿ëµÈ´Ù. |
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| ¿µ¹® | creatinine clearance | ÇÑ±Û | Å©·¹¾ÆÆ¼´Ñ û¼Ò |
|---|---|---|---|
| ¼³¸í | û¼Ò(clearance)¶õ ÇǼӿ¡¼ ¾î¶² ¹°ÁúÀ» Á¦°ÅÇÏ´Â ¼Óµµ¸¦ ÀǹÌÇÑ´Ù. ÇǼӿ¡¼ ¾î¶² ¹°ÁúÀ» Á¦°ÅÇÏ´Â °ÍÀº ÁÖ·Î ÄáÆÏÀÇ ¿ªÇÒÀ̹ǷΠÄáÆÏ¿¡¼ÀÇ ¾î¶² ¹°ÁúÀÌ Á¦°ÅµÇ´Â û¼ÒÀ²ÀÌ ÀÓ»óÀûÀ¸·Î Áß¿äÇÏ´Ù. ÄáÆÏ¿¡¼ÀÇ ¾î¶² ¹°ÁúÀÇ Ã»¼ÒÀ²Àº ´ÙÀ½°ú °°Àº ½ÄÀ¸·Î ±¸ÇØÁø´Ù. C(creatinine clearance) = V ¡¿ U / P C¶õ ÄáÆÏÀÇ Ã»¼ÒÀ²ÀÇ ¾àÀÚÀ̰í V´Â 1ºÐ´ç ³ª¿À´Â ¼Òº¯ÀÇ ¾çÀ¸·Î ml/minÀ̶õ ´ÜÀ§·Î Ç¥½ÃÇÑ´Ù. ±×¸®°í U¶õ ¼Òº¯¿¡ µé¾î Àִ û¼ÒÀ² ÃøÁ¤ÀÇ ´ë»óÀÌ µÇ´Â ¹°ÁúÀÇ ³óµµÀÌ´Ù. P¶õ û¼ÒÀ² ÃøÁ¤ÀÇ ´ë»óÀÌ µÇ´Â ¹°ÁúÀÇ Ç÷¾× ÁßÀÇ ³óµµ¸¦ ³ªÅ¸³½´Ù. Å©·¹¾ÆÆ¼´Ñ û¼Ò¶õ Å©·¹¾ÆÆ¾À̶ó´Â ¹°ÁúÀÇ Ã»¼ÒÀ²À» ³ªÅ¸³»´Â ¸»·Î ÄáÆÏ ±â´ÉÀÇ Æò°¡¿¡ ¸¹ÀÌ »ç¿ëµÇ´Â ÁöÇ¥ÀÌ´Ù. |
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| BIC | blood isotope clearance |
|---|---|
| DIC | dicarbazine; differential interference contrast microscopy; diffuse intravascular coagulation; direc... |
| ICG | indocyanine green; isotope cisternography |
| ID-MS | isotope dilution-mass spectrometry |
| ING | isotope nephrogram |
| GC-C-IRMS | Gas chromatography-combustion-isotope ratio mass spectrometry |
|---|---|
| IDMS | Isotope dilution mass spectrometry |
| IRMS | Isotope ratio mass spectrometry |
| KIE | Kinetic isotope effects |
| RI | Radio Isotope |
| isotope clearance | The rate at which an isotope is removed (usually by blood flow) from a tissue or organ such as the brain. (05 Mar 2000) |
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| radioactive isotope | <physics, radiobiology> An isotope of an element that has an unstable nucleus, it tries to stabilise itself by giving off ionising radiation. (09 Oct 1997) |
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| stable isotope | A nonradioactive nuclide; an isotope that shows no tendency to undergo radioactive decomposition. (05 Mar 2000) |
| daughter isotope | An element produced by radioactive decay of another. See: radionuclide generator, cow. (05 Mar 2000) |
| isotope | <radiobiology> One of several nuclides having the same number of protons in their nuclei and hence having the same atomic number, but differing in the number of neutrons and therefore, in the mass number. Almost identical chemical properties exist between isotopes of a particular element. The use of this term as a synonym for nuclide is to be discouraged. (16 Dec 1997) |
| isotope labeling | Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labelled substances unless the methods of labeling are substantively discussed. Tracers that may be labelled include chemical substances, cells, or microorganisms. (12 Dec 1998) |
| amylase-creatinine clearance ratio | A test for the diagnosis of acute pancreatitis; it is determined by measuring amylase and creatinine in serum and urine in apparently healthy individuals the renal clearance of amylase is less than 5% that of creatinine; in acute pancreatitis the ratio is said to be greater than 0.05 or 5%. (05 Mar 2000) |
| ANP clearance receptors | Cell surface proteins that bind atrial natriuretic peptide and ANP fragments without initiating biological action. (05 Mar 2000) |
| p-aminohippurate clearance | A good measure of renal plasma flow, which it slightly underestimates; when a low plasma concentration of p-aminohippurate (PAH) is maintained by intravenous infusion, the kidney extracts and excretes almost all of the PAH from the plasma before it reaches the renal vein. (05 Mar 2000) |
| maximum urea clearance | The urea clearance when the urine flow exceeds 2 ml/min; normal value is about 75 ml blood/min per 1.73 m2 body surface area. (05 Mar 2000) |
| metabolic clearance rate | Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site. (12 Dec 1998) |
| clearance | 1. The process of clearing. 2. <physiology> The rate at which a substance is removed from the blood. (18 Nov 1997) |
| mucociliary clearance | Rate of ciliary and secretory activity of the respiratory submucosal glands. It is a non-specific host defense mechanism, measurable in vivo by mucus transfer, ciliary beat frequency, and clearance of radioactive tracers. (12 Dec 1998) |
| creatinine clearance | Measurement of the clearance of endogenous creatinine, used for evaluating the glomerular filtration rate (GFR). (05 Mar 2000) |
| creatinine clearance test | <investigation, nephrology> A test of the amount of creatinine in blood or in blood and urine shows if the kidneys are working right or if one or both are diseased. (09 Oct 1997) |
| standard urea clearance | The value obtained when the square root of the urine flow (when below 2 ml/min) is multiplied by the urine urea concentration and divided by the whole blood urea concentration; represents an old empirical adjustment for the effect of low urine flow on urea excretion; sometimes corrected for body size by dividing by some function of body weight or surface area. Later, plasma concentration was substituted for blood concentration in the calculation. The normal value is about 54 ml/min per 1.73 m2 in an adult person. Synonym: Van Slyke's formula. (05 Mar 2000) |
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