| interleukin-12 | <cytokine> A 75 kD heterodimeric cytokine composed of disulfide-bonded 40 kD and 35 kD subunits that was originally identified by its ability to induce cytotoxic effector cells in synergy with less than optimal concentrations of interleukin-2. It is released by macrophages in response to infection and promotes the activation of cell-mediated immunity. Specifically, IL-12 triggers the maturation of Thl CD4 cells, specific cytotoxic T-lymphocyte responses and an increase in the activity of NK cells and consequently, it is the initiator of cell-mediated immunity. It enhances the lytic activity of NK cells, induces interferon production, stimulates the proliferation of activated T-cells and NK cells. Is secreted by human B lymphoblastoid cells (NC 37). May play a role in controlling immunoglobulin isotype selection as it also inhibits IgE synthesis (even in the presence of anti-IFN monoclonal antibody) and as a growth factor for activated CD4+ and CD8+ T-cells independently of interleukin-2, and for CD56+ NK cells but not resting peripheral blood mononuclear cells or resting or activated tonsillar B-cells. It is likely that interleukin 12 has a major role in protective immunity against viruses and is under study as an immunotherapy in HIV infection. Formerly referred to as cytotoxic lymphocyte maturation factor. Acronym: IL-12 (12 Dec 1998) |
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Synonyms : Cytotoxic Lymphocyte Maturation Factor, IL 12, IL-12 p70, IL12, Interleukin 12, Interleukin-12 p70, Interleukin 12 p70, p70, Interleukin-12
Synonyms : Interleukin-12 Receptor beta 1 Chain, Interleukin-12 Receptor p40 Subunit, Interleukin 12 Receptor beta 1 Chain, Interleukin 12 Receptor beta 1 Subunit, Interleukin 12 Receptor p40 Subunit
Synonyms : Interleukin-12 Receptor beta 2 Chain, Interleukin-12 Receptor p35 Subunit, Interleukin 12 Receptor beta 2 Chain, Interleukin 12 Receptor beta 2 Subunit, Interleukin 12 Receptor p35 Subunit
Synonyms : IL-12p35, Interleukin 12a, Interleukin-12 p35, Interleukin 12 Subunit p35, Interleukin 12 p35, Subunit p35, Interleukin-12
Synonyms : IL-12p40, Interleukin-12 beta Chain, Interleukin-12, 23 p40 Subunit, Interleukin-12b, Interleukin-23 Subunit p40, Chain, Interleukin-12 beta, Interleukin 12 Subunit p40, Interleukin 12 beta Chain, Interleukin 12, 23 p40 Subunit, Interleukin 12b
| interleukin-12 |
A substance that enhances the ability of the immune system to kill tumor cells, and that may interfere with blood flow to the tumor. Also called IL- 1 2.
출처: nydailynews.healthology.com/nydailynews/15836.htm
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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