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IBSP integrin-binding sialoprotein
ITG integrin
ITGA integrin alpha
ITGB integrin beta
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IAP Integrin Associated Protein
ILK Integrin Linked Kinase
INT integrin
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integrin modulating factor 1 <chemical> A lipid that alters the function of leukocyte integrins; may be an unsaturated fatty acid or an isoprenoid acid
Synonym: imf 1, imf-1
(05 Dec 1998)
integrin PS, Drosophila <chemical> Ps = position-specific; from eggs and testes; electrophoretic variant of notch protein; alpha subunit encoded by inflated (if) gene; beta subunit encoded by lethal(l)myospheroid (mys) gene; has been sequenced
Synonym: ps integrin, drosophila, alphaps1 integrin, alphaps2 integrin, betaps integrin
(05 Dec 1998)
integrin PS2 <chemical> Expressed on the surface of cells; can mediate cell spreading on an undefined component of fetal calf serum and on vertebrate matrix molecules vitronectin, fibronectin and rgdpeptide; amino acid sequence has been determined
Synonym: ps2 integrin
(05 Dec 1998)
integrins Superfamily of cell surface proteins that are involved in binding to extracellular matrix components in some cases. most are heterodimeric with a _ subunit of 95 kD that is conserved through the superfamily and a more variable _ subunit of 150-170 kD. The first examples described were fibronectin and vitronectin receptors of fibroblasts, which bind to an RGD (Arg Gly Asp) sequence in the ligand protein, though the context of the RGD seems important and there is also a divalent cation dependence. Subsequently the platelet IIb/IIIa surface glycoprotein (fibronectin and fibrinogen receptor) and the LFA 1 class of leucocyte surface protein were recognised as integrins, together with the VLA surface protein. The requirement for the RGD sequence in the ligand does not seem to be invariable.
(18 Nov 1997)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 5 ÆäÀÌÁö: 1
  • Integrin alpha Chains - »õâ The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short (>50 AA) with the exception of INTEGRIN ALPHA4.
    Synonyms : Integrin alpha Subunits, Integrins, alpha, alpha Chains, Integrin
  • Integrin alpha1 - »õâ An integrin alpha subunit that binds COLLAGEN and LAMININ though its I domain. It combines with INTEGRIN BETA1 to form the heterodimer INTEGRIN ALPHA1BETA1.
    Synonyms : CD49a Antigen, Integrin alpha(1), VLA-1 alpha Subunit, alpha1 Integrin, Antigen, CD49a, Integrin, alpha1, VLA 1 alpha Subunit, alpha Subunit, VLA-1
  • Integrin alpha1beta1 - »õâ Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.
    Synonyms : CD49a-CD29, Integrin alpha(1)beta(1), VLA-1, alpha1beta1 Integrin, Integrin, alpha1beta1, alpha1beta1, Integrin
  • Integrin alpha2 - »õâ An integrin alpha subunit that primarily combines with INTEGRIN BETA1 to form the INTEGRIN ALPHA2BETA1 heterodimer. It contains a domain which has homology to collagen-binding domains found in von Willebrand factor.
    Synonyms : CD49b Antigen, GPIa, Platelet Glycoprotein Ia, VLA-2 alpha Chain, alpha2 Integrin, Antigen, CD49b, Chain, VLA-2 alpha, Glycoprotein Ia, Platelet, Integrin, alpha2, VLA 2 alpha Chain, alpha Chain, VLA-2, alpha2, Integrin
  • Integrin alpha2beta1 - »õâ An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.
    Synonyms : CD49b-CD29, Glycoprotein Ia-IIa, Platelet Membrane Glycoprotein Heterodimer Ia-IIa, VLA-2, Very Late Antigen-2, alpha2beta1Integrin, CD49b CD29, Glycoprotein Ia IIa, Late Antigen-2, Very, Platelet Membrane Glycoprotein Heterodimer Ia IIa, VLA 2
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integrin A series of different cell surface recognition proteins comprised of two different subunits (referred to as a "heterodimer"). One subunit is derived from a series of subunits, and the second from a series of ?subunits, each of which is identified by a numerical identifier, or in one case (v) an alphabetical identifier. The combination of and ?subunits determines which matrix components will be recognised by the cell. 6? recognises laminin.
Ãâó: www.convatec.com/en_AU/tips/dictionary/wound_care....
integrin Proteins with alpha and beta subunits that bind to cells to communicate actions to them
Ãâó: student.biology.arizona.edu/honors2000/group10/Glo...
integrin Superfamily of cell surface proteins that are involved in binding to extracellular matrix components in some cases. Most are heterodimeric with a _ subunit of 95 kD that is conserved through the superfamily, and a more variable _ subunit of 150-170 kD. ...
Ãâó: worms.zoology.wisc.edu/urchins/SUglossary.html
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