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immortalization <cell biology> The ability of a genetically engineered cell line to reproduce indefinitely
The cells escape from the normal limitation on growth of a finite number of division cycles (the Hayflick limit), by variants in animal cell cultures and cells in some tumours.
Immortalisation in culture may be spontaneous, as happens particularly readily in mouse cells or induced by mutagens or by transfection of certain oncogenes.
(18 Nov 1997)
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immortalization The G0 phase (G zero) is a period in the cell cycle where cells exist in a quiescent state. Cells enter the G0 phase from a G1 phase checkpoint, such as the restriction point (animal cells) or the start point (yeast) usually in response to a lack of growth factors or nutrients. During the G0 phase, the cell-cycle machinery is dismantled and cyclins and cyclin-dependent kinases disappear. Some cells remain in the G0 phase until there is a reason for them to divide. ...
Ãâó: en.wikipedia.org/wiki/Immortalization
immortalization the acquisition by an eukaryotic cell line of the ability to grow through an indefinite number of divisions in culture.
Ãâó: www.hgsc.bcm.tmc.edu/docs/HGSC_glossary.html
immortalization The attainment by a finite cell culture, whether by perturbation or intrinsically, of the attributes of a continuous cell line. An immortalized cell is not necessarily one which is neoplastically or malignantly transformed.
Ãâó: www.sivb.org/edu_terminology.asp
immortalization a process of extending a cell life period and increasing the number of its divisions without a risk of turning into a tumor, thus extending an organism life period.
Ãâó: www.stvolkletki.ru/eng/dict/i.html
immortalization process by which cells in a culture can replicate indefinitely, usually through the introduction of a gene into the cell's DNA.
Ãâó: altweb.jhsph.edu/education/glossary.htm
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