| APRT | adenine phosphoribosyl transferase |
|---|---|
| GARS | glycine amide phosphoribosyl synthetase |
| HGPRT | hypoxanthine guanine phosphoribosyl transferase |
| NPR | net protein ratio; normal pulse rate; nucleoside phosphoribosyl |
| PFGS | phosphoribosyl formylglycinamide synthetase |
| PRPP | 5'-Phosphoribosyl-1-pyrophosphate |
|---|---|
| PP-ribose-P | 5'phosphoribosyl-l-pyrophosphate |
| CHO/HGPRT | Chinese hamster ovary cell hypoxanthine guanine phosphoribosyl transferase |
| HGPRT | Hypoxanthine Guanine Phosphoribosyl Transferase |
| HPRT | Hypoxanthine phosphoribosyl transferase |
| phosphoribosyl pyrophosphate | <chemical> The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides. Chemical name: alpha-D-Ribofuranose, 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate) (12 Dec 1998) |
|---|---|
| hypoxanthine-guanine phosphoribosyl tranferase marker | The gene which codes for the enzyme hypoxanthine-guanine phosphoribosyl transferase. It is a selectable marker because cells which have a defective version of this gene are resistant to poisoning by toxic purine derivatives which result from the metabolic pathway that the HGPRT enzyme catalyses. (The purine derivatives are toxic because they incorporate into DNA as a result of the HGPRT enzyme's actions). Because the defective gene cannot produce the enzyme, no toxic purine derivatives are produced, the gene can therefore be selected for. (09 Oct 1997) |
| hypoxanthine-guanine phosphoribosyl transferase | <enzyme> An enzyme which plays an important role in the making of ATP and GTP from guanine -- the only way guanine, adenine, or other purine molecules are able to become part of nucleic acids. Biologists study gene action via the incorporation of modified nitrogenous bases into DNA by manipulating the metabolic role which this enzyme plays. Similarly, the enzyme thymidine kinase is used for the same purpose by biologists because it fills the same important and unique role for the pyrimidines (thymine, cytosine, uracil, etc.). Acronym: HGPRT (09 Oct 1997) |
| N-(5'-phosphoribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase | <enzyme> Has beta/alpha-barrel fold structure; involved in biosynthesis of histidine Registry number: EC 5.3.1.16 Synonym: hisa gene product, pfacr isomerase, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (26 Jun 1999) |
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