| HAT | Halsted Aphasia Test; head, arm, trunk; heparin-associated thrombocytopenia; heterophil antibody tit... |
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| HGPRT | Hypoxanthine-Guanine Phospho-Ribosyl Transferase |
| HPRT | Hypoxanthine Phospho-Ribosyl-Transferase |
| AHU | acute hemolytic uremic [syndrome]; arginine, hypoxanthine, and uracil |
| HGPRT | hypoxanthine guanine phosphoribosyl transferase |
| CHO/HGPRT | Chinese hamster ovary cell hypoxanthine guanine phosphoribosyl transferase |
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| HX | Hypoxanthine |
| HGPRT | Hypoxanthine Guanine Phosphoribosyl Transferase |
| HPRT | Hypoxanthine guanine phosphoribosyltransferase |
| HPRT | Hypoxanthine phosphoribosyl transferase |
| hypoxanthine | Purine base present in inosine monophosphate (IMP) from which adenosine monophosphate (AMP) and guanosine monophosphate (GMP) are made. The product of deamination of adenine, 6 hydroxy purine. (18 Nov 1997) |
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| hypoxanthine guanine phosphoribosyltransferase | <enzyme> An enzyme that catalyses the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the lesch-nyhan syndrome, while partial deficiency results in overproduction of uric acid. Chemical name: IMP:pyrophosphate phospho-D-ribosyltransferase Registry number: EC 2.4.2.8 (12 Dec 1998) |
| hypoxanthine guanine phosphoribosyltransferase deficiency | A sex-linked inherited metabolic disorder; complete deficiency results in Lesch-Nyhan syndrome; incomplete deficiency is associated with acute gouty arthritis and renal stones. (05 Mar 2000) |
| hypoxanthine oxidase | <enzyme> Dehydrogenases involved in conversion of hypoxanthine to xanthine and xanthine to uric acid, as the final catabolism of purines. Deficient in the human disease xanthinuria. (18 Nov 1997) |
| hypoxanthine phosphoribosyltransferase | <enzyme> An enzyme that catalyses the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the lesch-nyhan syndrome, while partial deficiency results in overproduction of uric acid. Chemical name: IMP:pyrophosphate phospho-D-ribosyltransferase Registry number: EC 2.4.2.8 (12 Dec 1998) |
| hypoxanthine-aminopterin-thymine medium | A type of agar growth medium (a selective medium) which is used to select for cells that are able to make their nucleic acids out of hypoxanthine and/or thymine. All cells are prevented from making nucleotides by any other means (due to the presence of aminopterin or other drugs in the medium), so cells which are unable to use hypoxanthine and/or thymine to do this will not grow, multiply, and become visible colonies. This leaves the cells which are being selected for. (09 Oct 1997) |
| hypoxanthine-guanine phosphoribosyl tranferase marker | The gene which codes for the enzyme hypoxanthine-guanine phosphoribosyl transferase. It is a selectable marker because cells which have a defective version of this gene are resistant to poisoning by toxic purine derivatives which result from the metabolic pathway that the HGPRT enzyme catalyses. (The purine derivatives are toxic because they incorporate into DNA as a result of the HGPRT enzyme's actions). Because the defective gene cannot produce the enzyme, no toxic purine derivatives are produced, the gene can therefore be selected for. (09 Oct 1997) |
| hypoxanthine-guanine phosphoribosyl transferase | <enzyme> An enzyme which plays an important role in the making of ATP and GTP from guanine -- the only way guanine, adenine, or other purine molecules are able to become part of nucleic acids. Biologists study gene action via the incorporation of modified nitrogenous bases into DNA by manipulating the metabolic role which this enzyme plays. Similarly, the enzyme thymidine kinase is used for the same purpose by biologists because it fills the same important and unique role for the pyrimidines (thymine, cytosine, uracil, etc.). Acronym: HGPRT (09 Oct 1997) |
| hypoxanthine-guanine-xanthine phosphoribosyltransferase | <enzyme> From tritrichomonas foetus; in contrast to EC 2.4.2.8, this enzyme also uses xanthine as substrate; mw 24 kD Registry number: EC 2.4.2.- Synonym: hgxprtase (26 Jun 1999) |
| hypoxanthines | Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism. (12 Dec 1998) |
| tRNA-hypoxanthine ribosyltransferase | <enzyme> Incorporates hypoxanthine into mature trna molecules Registry number: EC 2.4.2.- Synonym: trna-hpx ribosyltransferase (26 Jun 1999) |
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Synonyms :
Synonyms : HGPRT, HPRTase, Hypoxanthine Guanine Phosphoribosyltransferase, Phosphoribosyltransferase, Guanine, Phosphoribosyltransferase, Hypoxanthine, Phosphoribosyltransferase, Hypoxanthine-Guanine, Pyrophosphorylase, IMP
Synonyms :
| hypoxanthine |
6-oxypurine, a purine base formed as an intermediate in the degradation of purines and purine nucleosides to uric acid and in the salvage of free purines. It is found in some transfer RNA molecules and occurs complexed with ribose as the nucleoside inosine.
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| hypoxanthine phosphoribosyltransferase |
[EC 2.4.2.8] an enzyme of the transferase class that catalyzes the phosphorylation of hypoxanthine or guanine to its corresponding nucleoside monophosphate, a salvage mechanism for recovery of preformed purines, especially in the central nervous system. Absence of enzyme activity, an X-linked trait, results in Lesch-Nyhan syndrome; partially decreased enzyme activity results in hyperuricemia and severe gouty arthritis, but the neurologic sequelae of Lesch-Nyhan syndrome do not occur. Called also hypoxanthine-guanine phosphoribosyltransferase.
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| hypoxanthine t. |
see Kossel's t.
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| hypoxanthine-guanine phosphoribosyltransferase |
hypoxanthine phosphoribosyltransferase.
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