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Gm an allotype marker on the heavy chains of immunoglobins
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FLC Free light chains
BH BCL-2 homology
CH Calponin homology
DH DBL-homology
EH Eps15 homology
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markov chains A stochastic process such that the conditional probability distribution for a state at any future instant, given the present state, is unaffected by any additional knowledge of the past history of the system.
(12 Dec 1998)
myosin heavy chains The heavy chains of the muscle protein myosin. Each molecule of myosin is composed of two heavy chains and two pairs of light chains. The heavy chains have a molecular weight of about 230 kD and each heavy chain is associated with a dissimilar pair of light chains. (devlin, textbook of biochemistry: with clinical correlations, 3rd ed, p957)
(12 Dec 1998)
beta-cell src-homology tyrosine kinase <enzyme> A murine frk (fyn-related kinase) homolog; genbank l36132; do not confuse with brain-specific kinase bsk
Registry number: EC 2.7.1.-
Synonym: beta-cell sh tk, bsk protein, sh tk, bsk gene product, sh tk
(26 Jun 1999)
homology <embryology, genetics> Two anatomical structures or behavioural traits within different organisms which originated from a structure or trait of their common ancestral organism.
The structures or traits in their current forms may not necessarily perform the same functions in each organism, nor perform the functions it did in the common ancestor. They may even have become completely unused and therefore vestigial.
Compare: analogy.
(09 Oct 1997)
homology of strands homology of chains
sequence homology <molecular biology> Strictly, refers to the situation where nucleic acid or protein sequences are similar because they have a common evolutionary origin. Often used loosely to indicate that sequences are very similar. Sequence similarity is observable, homology is an hypothesis based on observation.
(18 Nov 1997)
sequence homology, amino acid The degree of similarity between sequences of amino acids. This information is useful for the understanding of genetic relatedness of certain species.
(12 Dec 1998)
sequence homology, nucleic acid The sequential correspondence of nucleotide triplets in a nucleic acid molecule which permits nucleic acid hybridization. Sequence homology is important in the study of mechanisms of oncogenesis and also as an indication of the evolutionary relatedness of different organisms. The concept includes viral homology.
(12 Dec 1998)
src homology domains Regions of sequence similarity in the src family of cytoplasmic tyrosine kinases. The sh1 domain is a catalytic domain. Sh2 and sh3 domains are protein-binding domains. Sh2 usually binds phosphotyrosine-containing proteins and sh3 interacts with cytoskeletal proteins.
(12 Dec 1998)
DNA homology <molecular biology> How closely related two or more separate strands of DNA are to each other, based on their base sequences.
(09 Oct 1997)
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