| ISG | IFN stimulated genes |
|---|---|
| mdr | Multidrug resistance genes |
| stx | Shiga toxin genes |
| or genes | gene |
| rDNA | ribosomal DNA genes |
| homeotic genes | A group of genes that regulate the development of the body parts by defining the boundaries of the several regions. (05 Mar 2000) |
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| homeotic | Pertaining to or characterised by homeosis. (05 Mar 2000) |
|---|---|
| homeotic gene | <molecular biology> Gene, containing homeobox, the level of expression of which is set during embryongenesis in response to positional cues and which then directs the later formation of tissues and appendages appropriate to that part of the organism. Mutation of these genes leads to inappropriate expression of characteristics normally associated with another part of the organism (homeotic mutants. (18 Nov 1997) |
| homeotic mutant | <molecular biology> A mutant in which one body part, organ or tissue, is transformed into another part normally associated with another segment. Examples are the antennapedia and bithorax mutants of Drosophila. (18 Nov 1997) |
| homeotic mutation | <embryology, genetics> A mutation that causes an organism to develop a homologous body part or structure in place of the part or structure that should normally be there (for example, developing a hand in place of a foot). (09 Oct 1997) |
| homeotic selector gene | <molecular biology> The genes in the fruit fly Drosophila which code for the segmentation of the thorax (the bithorax complex) and the limbs and appendages, such as antennae and legs (antennapedia complex). (09 Oct 1997) |
| breast cancer susceptibility genes | Inherited factors that predispose to breast cancer. Put otherwise, these genes make one more susceptible to the disease and so increase the risk of developing breast cancer. Two of these genes, BRCA1 and BRCA2, have been identified (and prominently publicised). Several other genes (those for the Li-Fraumeni syndrome, Cowden disease, Muir-Torre syndrome, and ataxia-telangiectasia) are also known to predispose to breast cancer. However, since all of these known breast cancer susceptibility genes together do not account for more than a minor fraction (1/5th at most) of breast cancer that clusters in families, it is clear that more breast cancer genes remain to be discovered. (12 Dec 1998) |
| cancer, breast, susceptibility genes | Inherited factors that predispose to breast cancer. Put otherwise, these genes make one more susceptible to the disease and so increase the risk of developing breast cancer. Two of these genes, BRCA1 and BRCA2, have been identified (and prominently publicised). Several other genes (those for the Li-Fraumeni syndrome, Cowden disease, Muir-Torre syndrome, and ataxia-telangiectasia) are also known to predispose to breast cancer. However, since all of these known breast cancer susceptibility genes together do not account for more than a minor fraction (1/5th at most) of breast cancer that clusters in families, it is clear that more breast cancer genes remain to be discovered. (12 Dec 1998) |
| genes | Located in the nucleus of the cell, genes contain hereditary information that is transferred from cell to cell. (09 Oct 1997) |
| genes, abl | Retrovirus-associated DNA sequences (abl) originally isolated from the abelson murine leukaemia virus (ab-mulv). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukaemia. (12 Dec 1998) |
| genes, apc | Tumour suppressor genes located in the 5q21 region on the long arm of chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (apc stands for adenomatous polyposis coli) and gardner's syndrome, as well as some sporadic colourectal cancers. (12 Dec 1998) |
| genes, arac | Regulatory genes which encode a cyclic AMP receptor protein required for l-arabinose utilization in e. Coli. It is an example of positive control or regulation of gene expression in the bacterial operon. (12 Dec 1998) |
| genes, archaeal | The genetic material of archaea. (12 Dec 1998) |
| genes, bacterial | The genetic material of bacteria. (12 Dec 1998) |
| genes, bcl-1 | The B-cell leukaemia/lymphoma-1 genes, associated with various neoplasms when overexpressed. Overexpression results from the t(11;14) translocation, which is characteristic of mantle zone-derived B-cell lymphomas. The human c-bcl-1 gene is located at 11q13 on the long arm of chromosome 18. (12 Dec 1998) |
| genes, bcl-2 | The B-cell leukaemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18. (12 Dec 1998) |
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