| NYHA | New York Heart Association Heart Disease에 대한 Functional Classification &nbs... |
|---|---|
| HLA | histocompatibility leukocyte antigen; histocompatibility locus antigen; homologous leukocyte antibod... |
| BGC | basal ganglion calcification; blood group class |
| class, classif | classification |
| IV | ichthyosis vulgaris; initial visit; interventricular; intervertebral; intravaginal; intravascular; i... |
| HLA | Histocompatibility Antigens |
|---|---|
| MHC | Major histocompatibility antigens |
| MiHA | Minor histocompatibility antigens |
| MHC-II | Major Histocompatibility Complex class II |
| MHC-I | Major histocompatibility complex class I |
| histocompatibility antigens class II | Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-d antigens and are coded by a gene on chromosome 6. In mice, two genes named ia and i.e. On chromosome 17 code for the h-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term ia antigens used to refer only to the proteins encoded by the ia genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen. (12 Dec 1998) |
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| histocompatibility antigens class I | Large transmembrane, polymorphic glycoproteins noncovalently associated with nonpolymorphic beta 2-microglobulin. In humans, three structural genes on chromosome 6 code for the HLA-a, HLA-b and HLA-c antigens. In mice, three genes named k, d, and l on chromosome 17 code for the h-2 antigens. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognised during graft rejection and restrict cell-mediated lysis of virus-infected cells. They are primarily associated with rheumatologic diseases and certain malignant disorders. (12 Dec 1998) |
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| minor histocompatibility antigens | Allelic alloantigens often responsible for weak graft rejection in cases when (major) histocompatibility has been established by standard tests. In the mouse they are coded by more than 500 genes at up to 30 minor histocompatibility loci. The most well-known minor histocompatibility antigen in mammals is the h-y antigen. (12 Dec 1998) |
| histocompatibility antigens | A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection. (12 Dec 1998) |
| class I antigens | Cell membrane bound glycoproteins that are coded by genes of the major histocompatibility complex. (05 Mar 2000) |
| class II antigens | A cell membrane glycoprotein encoded by genes of the major histocompatibility complex. These antigens are distributed on antigen-presenting cells such as macrophages, B-cells, and dendritic cells. (05 Mar 2000) |
| class III antigens | Non-cell membrane molecules that are encoded by the S region of the major histocompatibility complex. These antigens are not involved in determining histocompatibility and include the complement proteins. (05 Mar 2000) |
| major histocompatibility antigen | <immunology> A set of plasmalemmal glycoprotein antigens involved in rapid (e.g. 7 days in the mouse) graft rejection and other immune phenomena. The minor histocompatibility antigens are involved in much slower rejection phenomena. The major antigens show remarkable polymorphism and occur as Class I and Class II types in mammals, birds may have a Class III molecule as well. See: histocompatibility antigens, MHC restriction. (18 Nov 1997) |
| major histocompatibility complex | The set of gene loci specifying major histocompatibility antigens, for example HLA in man, H 2 in mice, RLA in rabbits, RT 1 in rats, DLA in dogs, SLA in pigs, etc. Acronym: MHC (18 Nov 1997) |
| minor histocompatibility loci | Genetic loci responsible for the encoding of histocompatibility antigens other than those encoded by the major histocompatibility complex. The antigens encoded by these genes are often responsible for graft rejection in cases where histocompatibility has been established by standard tests. The location of some of these loci on the x and y chromosomes explains why grafts from males to females may be rejected while grafts from females to males are accepted. In the mouse roughly 30 minor histocompatibility loci have been recognised, comprising more than 500 genes. (12 Dec 1998) |
| H2 histocompatibility | <immunology> The ability of a tissue to be grafted from a donor to a host, without the host's immune system attacking the grafted tissue. The chances of H2 histocompatibility is determined by how well the tissue proteins (cell surface glycoproteins in the tissue, to be specific) match between donor and host. (09 Oct 1997) |
| histocompatibility | If tissues of two organisms are histocompatible, then grafts between the organisms will not be rejected. If, however, major histocompatibility antigens are different then an immune response will be mounted against the foreign tissue. (18 Nov 1997) |
| histocompatibility antigen | <immunology> A set of plasmalemmal glycoproteins on the surface of all nucleated cells that are crucial for T-cell recognition of antigens. Particularly the HLA system in humans and the H2 system in mice. They are the major antigens responsible for tissue recognition. For this reason, they are of prime importance in determining compatible organ donors for a specific transplantation procedure. Each person has unique HLA antigens. Some HLA antigens have been identified to be correlated with the presence of certain autoimmune diseases. One of these is the HLA-B27 site. Approximately 85% of patients with ankylosing spondylitis and Reiter's syndrome will have the HLA-B27 antigen present on the leukocytes. There are two classes of histocompatibility antigens: 1. Class I, histocompatibility antigens composed of two glycosylated subunits, a heavy chain of 44 kD and beta2 microglobulin (12 kD). The heavy chain may be coded by K, D or L genes of mouse H2 and A, B or C genes of human HLA complex. Class I antigens are important in T-cell killing and are recognised in conjunction with the foreign cell surface antigens MHC restriction). 2. Class II antigens, heterodimeric histocompatibility antigens composed of alpha (32 kD) and beta (28 kD) chains. Found mostly on B lymphocytes, macrophages and accessory cells. The response of T helper cells requires that the foreign antigen is presented in conjunction with the appropriate Class II antigens. (Murine H2 Ia antigens and human HLA DR antigens are Class II). (14 Oct 1997) |
| histocompatibility complex | A family of fifty or more genes on the sixth human chromosome that code for cell surface proteins and play a role in the immune response.Histocompatibility genes control the production of proteins on the outer membranes of tissue and blood cells, especially lymphocytes, and are vital elements in cell-cell recognition. The proteins also determine the level and type of immune response, and may serve other biochemical or immunologic functions. In the case of allografts, it is necessary to determine whether donor and recipient possess compatible sets of proteins (histocompatibility antigens), to minimise the likelihood of rejection. Histocompatibility testing (HLA tissue typing) provides this information. (05 Mar 2000) |
| histocompatibility gene | In laboratory animals, a gene which can elicit an immune response and thereby cause rejection of a homograft when tissue is transplanted from one individual to another; in humans, histocompatibility gene's control HLA antigens. Synonym: H gene. (05 Mar 2000) |
| histocompatibility testing | Identification of the major histocompatibility antigens of transplant donors and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical abo blood group, and in addition should be matched as closely as possible for histocompatibility antigens in order to minimise the likelihood of allograft rejection. (12 Dec 1998) |
Synonyms : Class II Antigen, Class II Histocompatibility Antigens, Class II Major Histocompatibility Antigens, I-A Antigen, I-A-Antigen, IA Antigen, Antigen, Class II, Antigen, I-A, Antigen, IA, Antigens, Class II, Antigens, Ia, Antigens, Ia-Like, Antigens, Immune-Associated
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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