| CLD | chloride diarrhea; chronic liver disease; chronic lung disease; congenital limb deficiency; crystal ... |
|---|---|
| MLC | minimum lethal concentration; mixed leukocyte culture; mixed ligand chelate; mixed lymphocyte concen... |
| MLCT | metal-to-ligand charge transfer |
| HARD | hydrocephalus-agyria-retinal dysplasia [syndrome] |
| HARD | +/- E hydrocephalus-agyria-retinal dysplasia plus or minus encephalocele [syndrome] |
| APO2L | AP02 ligand |
|---|---|
| CD30L | CD30 ligand |
| CD40L | CD40 Ligand |
| CD40L | CD40-CD40 ligand |
| CD95L | CD95 ligand |
| ambident ligand | <chemistry> A ligand that can donate electrons through two or more atoms on their molecule. (05 Feb 1998) |
|---|---|
| cyanocobalamin beta-ligand transferase | <enzyme> Cytosolic enzyme utilizing fad, NADPH and reduced glutathione; forms glutathionylcobalamin from cyanocobalamin Registry number: EC 2.5.1.- Synonym: ccbl transferase (26 Jun 1999) |
| ELAM-1 ligand fucosyltransferase | <enzyme> Directs the expression of an elam-1 ligand; an alpha(1,3) fucosyltransferase Registry number: EC 2.4.1.- Synonym: elft protein, elft gene product (26 Jun 1999) |
| ligand | <chemistry, immunology> Any molecule that binds to another, in normal usage a soluble molecule such as a hormone or neurotransmitter, that binds to a receptor. The decision as to which is the ligand and which the receptor is often a little arbitrary when the broader sense of receptor is used (where there is no implication of transduction of signal). In these cases it is probably a good rule to consider the ligand to be the smaller of the two thus in a lectin sugar interaction, the sugar would be the ligand (even though it is attached to a much larger molecule, recognition is of the saccharide). (18 Nov 1997) |
| ligand binding site | The site on a protein's surface that binds a ligand; equivalent to the active site if the ligand is the substrate of an enzyme. (05 Mar 2000) |
| ligand-gated channel | A class of ion channel's whose ionic permeability is regulated by cell membrane receptors that respond to specific extracellular chemical signals. (05 Mar 2000) |
| ligand gated ion channel | A transmembrane ion channel whose permeability is increased by the binding of a specific ligand, typically a neurotransmitter at a chemical synapse. The permeability change is often drastic, such channels let through effectively no ions when shut, but allow passage at up to 10exp7 ions sexp 1 when a ligand is bound. Recently, the receptors for both acetylcholine and GABA have been found to share considerable sequence homology, implying that there may be a family of structurally related ligand gated ion channels. (18 Nov 1997) |
| ligand induced endocytosis | The formation of coated pits and then coated vesicles as a consequence of the interaction of ligand with receptors, which then interact with clathrin and associated proteins (coatomers) on the cytoplasmic face of the plasma membrane and come together to form a pit. Not all coated vesicle uptake of receptors requires receptor occupancy. (18 Nov 1997) |
| palate, hard | The bony part of the roof of the mouth. The hard palate is just in front of the soft palate. (12 Dec 1998) |
| hard | 1. With pressure; with urgency; hence, diligently; earnestly. "And prayed so hard for mercy from the prince." (Dryden) "My father Is hard at study; pray now, rest yourself." (Shak) 2. With difficulty; as, the vehicle moves hard. 3. Uneasily; vexatiously; slowly. (Shak) 4. So as to raise difficulties. " The guestion is hard set". (Sir T. Browne) 5. With tension or strain of the powers; violently; with force; tempestuously; vehemently; vigorously; energetically; as, to press, to blow, to rain hard; hence, rapidly; as, to run hard. 6. Close or near. "Whose house joined hard to the synagogue." (Acts xviii.7) Hard by, near by; close at hand; not far off. "Hard by a cottage chimney smokes." . Hard pushed, Hard run, greatly pressed; as, he was hard pushed or hard run for time, money, etc. Hard up, closely pressed by want or necessity; without money or resources; as, hard up for amusements. Hard in nautical language is often joined to words of command to the helmsman, denoting that the order should be carried out with the utmost energy, or that the helm should be put, in the direction indicated, to the extreme limit, as, Hard aport! Hard astarboard! Hard alee! Hard aweather up! Hard is also often used in composition with a participle; as, hard-baked; hard-earned; hard-working; hard-won. Origin: OE. Harde, AS. Hearde. 1. Not easily penetrated, cut, or separated into parts; not yielding to pressure; firm; solid; compact; applied to material bodies, and opposed to soft; as, hard wood; hard flesh; a hard apple. 2. Difficult, mentally or judicially; not easily apprehended, decided, or resolved; as a hard problem." "The hard causes they brought unto Moses." (Ex. Xviii. 26) "In which are some things hard to be understood." (2 Peter III. 16) 3. Difficult to accomplish; full of obstacles; laborious; fatiguing; arduous; as, a hard task; a disease hard to cure. 4. Difficult to resist or control; powerful. "The stag was too hard for the horse." (L'Estrange) " A power which will be always too hard for them." (Addison) 5. Difficult to bear or endure; not easy to put up with or consent to; hence, severe; rigorous; oppressive; distressing; unjust; grasping; as, a hard lot; hard times; hard fare; a hard winter; hard conditions or terms. "I never could drive a hard bargain." (Burke) 6. Difficult to please or influence; stern; unyielding; obdurate; unsympathetic; unfeeling; cruel; as, a hard master; a hard heart; hard words; a hard character. 7. Not easy or agreeable to the taste; stiff; rigid; ungraceful; repelling; as, a hard style. "Figures harder than even the marble itself." (Dryden) 8. Rough; acid; sour, as liquors; as, hard cider. 9. (Pron) Abrupt or explosive in utterance; not aspirated, sibilated, or pronounced with a gradual change of the organs from one position to another;- said of certain consonants, as c in came, and g in go, as distinguished from the same letters in center, general, etc. 10. Wanting softness or smoothness of utterance; harsh; as, a hard tone. 11. Rigid in the drawing or distribution of the figures; formal; lacking grace of composition. Having disagreeable and abrupt contrasts in the colouring or light and shade. Hard cancer, Hard case, etc. See Cancer, Case, etc. Hard clam, or Hard-shelled clam, a smooth finishing coat of hard fine plaster applied to the surface of rough plastering. Hard lines, hardship; difficult conditions. Hard money, coin or specie, as distinguished from paper money. <zoology> Hard oyster, the northern native oyster. Hard pan, the hard stratum of earth lying beneath the soil; hence, figuratively, the firm, substantial, fundamental part or quality of anything; as, the hard pan of character, of a matter in dispute, etc. See Pan. Hard rubber. See Rubber. Hard solder. See Solder. Hard water, water, which contains lime or some mineral substance rendering it unfit for washing. See Hardness.- Hard wood, wood of a solid or hard texture; as walnut, oak, ash, box, and the like, in distinction from pine, poplar, hemlock, etc.- In hard condition, in excellent condition for racing; having firm muscles;-said of race horses. Synonym: Solid, arduous, powerful, trying, unyielding, stubborn, stern, flinty, unfeeling, harsh, difficult, severe, obdurate, rigid. See Solid, and Arduous. Origin: OE. Heard, AS. Heard; akin to OS. & D. Heard, G. Hart, OHG. Harti, Icel. Harr, Dan. Haard, Sw. Hard, Goth. Hardus, Gr. Strong, strength, and also to E. -ard, as in coward, drunkard, -crat, -cracy in autocrat, democracy; cf. Skr. Kratu strength, to do, make. Gf.Hardy. Source: Websters Dictionary (01 Mar 1998) |
| hard cataract | A cataract involving the nucleus. Synonym: hard cataract. (05 Mar 2000) |
| hard chancre | <dermatology> The primary skin lesion of syphilis which begins at the site of infection after an interval of 10-30 days as a papule or red ulcerated skin lesion. (27 Sep 1997) |
| hard corn | The usual form of corn over a toe joint. Synonym: heloma durum. (05 Mar 2000) |
| hard grass | <botany> A name given to several different grasses, especially to the Roltbollia incurvata, and to the species of aegilops, from one of which it is contended that wheat has been derived. Source: Websters Dictionary (01 Mar 1998) |
| hard-hearted | Unsympathetic; inexorable; cruel; pitiless. Hard"-heartedness. Source: Websters Dictionary (01 Mar 1998) |
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