| haemolysins | Substances, usually of biological origin, that destroy blood cells; they may be antibodies or other immunologic factors, toxins, enzymes, etc.; haemotoxins are toxic to blood in general, including the clotting mechanism; haematotoxins may refer to the haematopoietic system. (12 Dec 1998) |
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| thiol activated haemolysins | Cytolytic bacterial exotoxins that act by binding to cholesterol in cell membranes and forming ring like complexes that act as pores. SH groups of these toxins must be in the reduced state for the toxin to function. Oxidation (to disulphide bridges) inactivates the toxin. Examples: tetanolysin, streptolysin O, _ toxin, cereolysin. (18 Nov 1997) |
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