| 영문 | guanine | 한글 | 구아닌 |
|---|---|---|---|
| 설명 | DNA나 RNA의 구성요소로 염기 중의 하나. |
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| 영문 | gout | 한글 | 통풍 |
|---|---|---|---|
| 설명 | 유전정보를 보관하는 물질인 DNA와 RNA 등을 이루는 핵산은 요산의 형태로 배설이 된다. 이것의 배설에는 여러 가지 효소가 작용한다. 이중에서 HGPRT (Hypoxanthine-Guanine Phosphoribosyl Transferase)라는 효소는 이미 배설이 되려고 요산으로 변환하는 과정의 물질을 다시 핵산으로 바꾸는 작용을 하는 효소이다. 통풍이란 이 HGPRT라는 효소 활성도가 감소되어 발생된다. 이 효소의 활성도가 감소되면 핵산의 배설단계에서 재사용이라는 단계가 없어지므로 과도한 요산의 생성이 있게 된다. 혈중에 과도한 요산이 존재하고 이 요산은 결정을 만들어서 관절 주위 및 연부 조직에 침착되어 격심한 발작성 관절통을 야기하는 급성 염증성 관절염을 일으키는 특징적인 병이다. 또 이 요산의 결정들이 콩팥이나 심장에 축적되어서 콩팥 및 심혈관계에 장애가 발생할 수도 있어 내과적 치료를 요하는 병이다. 유전 양식상 보통염색체 우성으로 유전하는 유전병이다. 보통염색체 우성 유전을 하지만 남자와 여자에서 표현률이 달라서 남자가 95%이상을 차지한다. |
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| ABC | absolute basophil count; absolute bone conduction; acalculous biliary colic; acid balance control; a... |
|---|---|
| PRAGMATIC | pregnancy, rheumatoid arthritis, acromegaly, glucose metabolism disorders, mechanical injury, amyloi... |
| HGPRT | Hypoxanthine-Guanine Phospho-Ribosyl Transferase |
| 6-TG | 6-Thio-Guanine |
| ATG | adenine-thymidine-guanine antihuman thymocyte globulin; antithrombocyte globulin; antithymocyte glob... |
| 7-MG | 7-methyl guanine |
|---|---|
| 8AG | 8-aza-guanine |
| DHPG | 9(1,3-dihydroxy-2-propoxymethyl) guanine |
| G | A)-guanine |
| CHO/HGPRT | Chinese hamster ovary cell hypoxanthine guanine phosphoribosyl transferase |
| arthritis, gout | Joint inflammation caused by uric acid crystal deposits in the joint space An attack is usually extremely painful.The uric acid crystals are deposited in the joint fluid (synovial fluid) and joint lining (synovial lining). Intense joint inflammation occurs as white blood cells engulf the uric acid crystals, causing pain, heat, and redness of the joint tissues. The term gout commonly is used to refer to these painful arthritis attacks but gouty arthritis is only one manifeatation of gout. (12 Dec 1998) |
|---|---|
| calcium gout | <rheumatology> Chondrocalcinosis, chronic recurrent arthritis clinically similar to gout. (27 Sep 1997) |
| masked gout | latent gout |
| retrocedent gout | An obsolete term for the occurrence of severe gastric, cardiac, or cerebral symptoms during an attack of gout, especially when the joint and other symptoms suddenly subside at the same time. Saturnine gout, gout occurring in a person with lead poisoning. Synonym: lead gout. Secondary gout, gout resulting from increased serum uric acid levels as a result of an antecedent disease, such as a proliferative disease of the blood and bone marrow, lead poisoning, or prolonged chronic renal failure (on dialysis). Tophaceous gout, gout in which deposits of uric acid and urates occur as gouty tophi. (05 Mar 2000) |
| gout | <rheumatology> Recurrent acute arthritis of peripheral joints caused by the accumulation of monosodium urate crytals. Often presents as pain and swelling confined to one joint. The big toe joint is commonly affected. The arthritis occurs secondary to an inherited abnormality of purine metabolism, resulting in the deposition of uric acid crystals (sodium urate) within the joint space and articular cartilage. Usually due to overproduction of uric acid but may be a result of under excretion. The problems partly arise because neutrophils release lysosomal enzymes as a result of damage to the phagosome membrane by ingested crystals: colchicine acts to reduce the attack by inhibiting lysosome phagosome fusion. (18 Nov 1997) |
| gout arthritis | <rheumatology> Recurrent acute arthritis of peripheral joints caused by the accumulation of monosodium urate crytals. Often presents as pain and swelling confined to one joint. The big toe joint is commonly affected. The arthritis occurs secondary to an inherited abnormality of purine metabolism, resulting in the deposition of uric acid crystals (sodium urate) within the joint space and articular cartilage. Usually due to overproduction of uric acid but may be a result of under excretion. The problems partly arise because neutrophils release lysosomal enzymes as a result of damage to the phagosome membrane by ingested crystals: colchicine acts to reduce the attack by inhibiting lysosome phagosome fusion. (18 Nov 1997) |
| gout diet | A diet containing a minimal quantity of purine bases (meats); liver, kidney, and sweetbread especially are excluded and replaced by dairy products, fruits, and cereals; alcoholic beverages also are excluded. Synonym: purine-free diet. (05 Mar 2000) |
| gout suppressants | Agents that increase uric acid excretion by the kidney (uricosuric agents), decrease uric acid production (antihyperuricaemics), or alleviate the pain and inflammation of acute attacks of gout. (12 Dec 1998) |
| gout, tophaceous | A form of chronic gout. Nodular masses of uric acid crystals (tophi) are deposited in different soft tissue areas of the body. Even though tophi are most commonly found as hard nodules around the fingers, at the tips of the elbows, and around the big toe, tophi nodules can appear anywhere in the body. They have been reported in unexpected areas such as in the ears, vocal cords, or around the spinal cord! (12 Dec 1998) |
| guanine | <biochemistry, molecular biology> One of the constituent bases of nucleic acids, nucleosides and nucleotides. (18 Nov 1997) |
| guanine aminase | <enzyme> An enzyme that catalyses the deamination of guanine to form xanthine. Chemical name: Guanine aminohydrolase Registry number: EC 3.5.4.3 (12 Dec 1998) |
| guanine cell | A cell whose cytoplasm contains glistening crystals of guanine. (05 Mar 2000) |
| guanine deaminase | <enzyme> An enzyme that catalyses the deamination of guanine to form xanthine. Chemical name: Guanine aminohydrolase Registry number: EC 3.5.4.3 (12 Dec 1998) |
| guanine deoxyribonucleotide | Deoxyguanosine monophosphate, a hydrolysis product of DNA. Synonym: guanine deoxyribonucleotide. (05 Mar 2000) |
| guanine ribonucleotide | A major component of ribonucleic acids. Synonym: guanine ribonucleotide, guanosine 5'-monophosphate. Guanylic acid reductase (GMP reductase), an enzyme that catalyses the reaction of GMP with NADPH producing IMP, NH3, and NADP+; a part of the purine salvage pathway. Guanylic acid synthetase (GMP synthetase), an enzyme catalyzing the reaction of l-glutamine, XMP, and ATP to produce GMP, l-glutamate, AMP, and pyrophosphate; a key step in purine biosynthesis. Acronym: GMP (05 Mar 2000) |
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|