| 영문 | iron deficiency anemia | 한글 | 철결핍빈혈 |
|---|---|---|---|
| 설명 | 적혈구의 기능은 산소를 운반하는데 있다. 적혈구 속에 산소와 결합을 하여 산소를 운반하는 혈색소라는 물질이 있다. 철은 이 혈색소의 중요한 부분을 이루는 것으로 철이 없으면 혈색소가 만들어질 수가 없다. 혈색소가 없으면 역시 적혈구도 만들어지지 않으므로 체내에 철이 부족하면 빈혈이 생긴다. 이 철결핍성 빈혈은 빈혈의 원인 중에서 가장 흔한 것이다(약 25%를 차지한다). 철저장량의 저하-결핍, 혈청철농도의 저하, 트란스페린량 상승, 트란스페린포화도의 저하, 혈색소농도 또는 헤마토크리트의 저하, 저색소성대적혈구를 특징으로 하는 빈혈로서, 생체 내에서 철이 장기에 걸쳐 결핍되며 그 때문에 혈색소 생산 감소에 의해 일어난다. 창자에서의 철흡수량 부족, 철의 수요 증대(유아기, 사춘기, 임신), 철소실과잉(출혈)에 의해 일어나며, 특히 사춘기에서 폐경기까지의 여성에게 많다. 증상으로서는 얼굴창백, 피로감, 피부창백, 손톱 변화(스푼 모양) 등을 나타낸다. 구강 영역에서는 혀의 접촉통, 발적, 건조감, 삼킴곤란을 수반하면 플러머-빈슨(Plummer-Vinson)증후군이라고 한다. 혈액 소견은 혈청철은 저하하며, 철결합능력의 상승, 저색소성 작은적혈구성을 나타낸다. |
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| MD | Doctor of Medicine [Lat. Medicinae Doctor]; magnesium deficiency; main duct; maintenance dose; major... |
|---|---|
| E-GR | erythrocyte glutathione reductase |
| EGRAC | erythrocyte glutathione reductase activity coefficient |
| GR | gamma-rays; gastric resection; general research; generalized rash; glucocorticoid receptor; glutathi... |
| GSR | galvanic skin response; generalized Shwartzman reaction; glutathione reductase |
| GR | Glutathione reductase |
|---|---|
| E-GR | erythrocyte glutathione reductase |
| EGR-AC | erythrocyte glutathione reductase activity coefficient |
| GRD | glutathione reductase |
| HMG-CoA reductase | 3-Hydroxy-3-methylglutaryl CoA reductase |
| glutathione synthetase deficiency | An inborn error of metabolism associated with massive urinary excretion of 5-oxyproline, elevated levels of 5-oxyproline in the blood and cerebrospinal fluid, severe metabolic acidosis, tendency toward haemolysis, and defective central nervous systems function. Glutathione synthetase deficiency has been reported as a generalised condition or with a deficiency restricted to erythrocytes. (05 Mar 2000) |
|---|---|
| glutathione reductase | <enzyme> An FAD containing enzyme, a dimer of 50 kD subunits. It catalyses the NADP dependent reduction of glutathione disulphide (GSSG) to glutathione (GSH). This is an essential reaction that maintains a GSH:GSSG ratio in the cytoplasm of _500:1. (18 Nov 1997) |
| protein disulfide reductase (glutathione) | <enzyme> An enzyme that catalyses the reduction of a protein-disulfide in the presence of glutathione, forming a protein-dithiol. Insulin is one of its substrates. Chemical name: Glutathione:protein-disulfide oxidoreductase Registry number: EC 1.8.4.2 (12 Dec 1998) |
| reduced glutathione | Glutathione acting as a hydrogen donor. (05 Mar 2000) |
| glutathione | <biochemistry> The tripeptide _ glutamylcysteinylglycine. It contains an unusual peptide linkage between the _ carboxyl group of the glutamate side chain and the amine group of cysteine. The concentration of glutathione in animal cells is _5mM and its sulphydryl group is kept largely in the reduced state. This allows it to act as a sulphydryl buffer, reducing any disulphide bonds formed within cytoplasmic proteins to cysteines. Hence, few, if any, cytoplasmic proteins contain disulphide bonds. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids and participates in leucotriene synthesis. (18 Nov 1997) |
| glutathione disulfide | <chemical> A glutathione derivative that forms when the sulfhydryl side chains of the cysteine residues of two glutathione molecules form a disulfide bond during the course of being oxidised with various oxides and peroxides in cells. Glutathione reductase, with the coupled oxidation of NADPH, reduces gssg to two moles of glutathione. Chemical name: Bis(gamma-Glutamyl-L-cysteinylglycine) Disulfide (12 Dec 1998) |
| glutathione oxidase | <enzyme> Oxygen-dependent conversion of glutathione to glutathione disulfide Registry number: EC 1.8.4.- Synonym: renal thiol oxidase, renal sulfhydryl oxidase, intestinal thiol oxidase, kidney thiol oxidase (26 Jun 1999) |
| glutathione peroxidase | <enzyme> A detoxifying enzyme that eliminates hydrogen peroxide and organic peroxides. Glutathione is an essential cofactor for the enzyme and its reaction involves the oxidation of glutathione (GSH) to glutathione disulphide (GSSG). The GSSG is then reduced to GSH by glutathione reductase. Glutathione peroxidase, (GPX), has a selenocysteine residue in its active site. Three forms of the enzyme exist: cy toplasmic GPX, plasma GPX and phospholipid hydroperoxide GPX. (18 Nov 1997) |
| glutathione S-transferase | A class of enzymes that catalyze the reaction of glutathione with an acceptor molecule (e.g., an arene oxide) to form an S-substituted glutathione; a key step in detoxification of many substances; start of the mercapturic acid pathway. Synonym: ligandin. (05 Mar 2000) |
| glutathione synthase | <enzyme> One of the enzymes active in the gamma-glutamyl cycle. It catalyses the synthesis of glutathione from gamma-glutamylcysteine and glycine in the presence of ATP with the formation of ADP and orthophosphate. Chemical name: gamma-L-Glutamyl-L-cysteine:glycine ligase (ADP-forming) Registry number: EC 6.3.2.3 (12 Dec 1998) |
| glutathione synthetase | <enzyme> An enzyme that catalyses the formation of glutathione, ADP, and orthophosphate from gamma-glutamylcysteine, ATP, and glycine; a deficiency will lead to metabolic acidosis and progressive brain dysfunction. (05 Mar 2000) |
| glutathione transferase | <enzyme> A transferase that catalyses the addition of aliphatic, aromatic, or heterocyclic radicals as well as epoxides and arene oxides to glutathione. Addition takes place at the sulfur atom. It also catalyses the reduction of polyol nitrate by glutathione to polyol and nitrite. Chemical name: RX:glutathione R-transferase Registry number: EC 2.5.1.18 (12 Dec 1998) |
| phospholipid-hydroperoxide glutathione peroxidase | <enzyme> Selenoenzyme found in biological materials; different from glutathione peroxidase EC 1.11.1.9 Registry number: EC 1.11.1.- Synonym: pH-gperoxidase (26 Jun 1999) |
| S-(dinitrophenyl)glutathione ATPase | <enzyme> Anionic conjugates of bilirubin and bile acids stimulate the hydrolysis of the above enzyme of human erythrocyte; also found in other tissue Registry number: EC 3.6.1.- Synonym: dnp-sg-atpase (26 Jun 1999) |
| sulfobromophthalein-glutathione conjugase | <enzyme> Similar to EC 2.5.1.18; non-microsomal enzyme involving transfer of the dye from plasma to hepatic parenchymal cells, cellular storage, enzymatic intracellular conjugation with reduced glutathione and rate limited excretion into the bile; activity of this enzyme is used to determine conjugating ability of the liver Registry number: EC 2.5.1.- Synonym: bromsulphthalein-glutathione conjugating enzyme (26 Jun 1999) |
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|