| ¿µ¹® | gene therapy | ÇÑ±Û | À¯ÀüÀÚ¿ä¹ý |
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| ¼³¸í | À¯Àüº´À» Ä¡·áÇÒ ¸ñÀûÀ¸·Î, Á¤»óÀûÀ¸·Î ±â´ÉÇÏ´Â ´ÜÀÏÀ¯ÀüÀÚ È¤Àº º¹¼öÀ¯ÀüÀÚ¸¦ ¾î¶² ±â¿ø¿¡¼ ¾ò¾î³»¾î »ý¼¼Æ÷¿¡ µµÀÔÇÏ´Â °Í. À¯Àü¹°ÁúÀº À¯ÀüÀÚ»ðÀÔ Á¶ÀÛ¿¡ ÀÇÇØ ¼ö¿ë¼¼Æ÷¿¡·Î µµÀԵȴÙ. Áï, À¯ÀüÀÚ¸¦ ³¢¿ö ³ÖÀº »õ·Î¿î ¼¼Æ÷¸¦ »ç¿ëÇÏ´Â Ä¡·á·Î¼ 1980³â ¹Ì±¹ÀÇ ÇÐÀÚ°¡ ÁöÁßÇØºóÇ÷ȯÀÚ¿¡°Ô °ÇàÇÏ¿© ºñÆÇÀ» ¹Þ¾ÒÁö¸¸, ¹Ì±¹ ±¹¸³º¸°Ç¿¬±¸¼Ò´Â 1990³â 9¿ù ¾Æµ¥³ë½Å µ¥¾Æ¹Ì³ª¾ÆÁ¦(adenosine deaminase, ADA) °áÇÌÁõ ȯÀÚÀÇ ¸²ÇÁ±¸¿¡ ADA À¯ÀüÀÚ¸¦ ³¢¿ö ³Ö´Â Ä¡·á¸¦ ½ÃÀÛÇÑ ÀÌ·¡ ÇöÀç´Â ¾ÏÀ» Æ÷ÇÔÇÑ ¸¹Àº Áúº´µéÀ» Ä¡·áÇÏ´Â ¸ñÀûÀ¸·Î ¾²ÀδÙ. |
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| ¿µ¹® | gene | ÇÑ±Û | À¯ÀüÀÚ |
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| ¼³¸í | À¯ÀüÀÚ´Â ±æ°Ô ¶ì¸¦ Çü¼ºÇÑ DNAºÐÀÚÀÇ ÀϺκÐÀ¸·Î ÇÑ °¡Áö ¹°ÁúÀ» ¸¸µå´Âµ¥ ÇÊ¿äÇÑ ¸ðµç Á¤º¸¸¦ °®Ãá ±â´ÉÀûÀÎ ´ÜÀ§ÀÌ´Ù. ¿¹¸¦ µé¾î Àν¶¸°À̶ó´Â ¹°ÁúÀÇ À¯ÀüÀÚ¶ó°í ÇÏ¸é »ç¶÷ÀÇ ¼¼Æ÷³»¿¡ ÀÖ´Â ±ä DNA ºÐÀÚ Áß¿¡¼ Àν¶¸°À̶ó´Â ¹°ÁúÀ» ¸¸µå´Âµ¥ ÇÊ¿äÇÑ ¸ðµç Á¤º¸¸¦ °¡Áö°í ÀÖ´Â ÇÑ ºÎºÐÀ» °¡¸®Å°´Â ¸»ÀÌ´Ù. °íÀüÀûÀÎ »ý¹°Çп¡¼´Â À¯ÀüÀÚ°¡ Ç¥ÇöÇüÀ» °áÁ¤Çϰųª ÁöÁ¤ÇÏ´Â ¿°»öüÀÇ ÀϺκÐÀ̶ó°í Á¤ÀǵǾúÁö¸¸, ¿À´Ã³¯¿¡´Â À¯ÀüÀÚ¿¡ ´ëÇØ¼ ºÐÀÚÀû Á¤Àǰ¡ Á¦¾ÈµÇ°í ÀÖÀ¸¸ç ±× Á¤ÀÇ´Â ÇϳªÀÇ À¯ÀüÀÚ´Â ÇϳªÀÇ È¿¼Ò¸¦ °áÁ¤ ¶Ç´Â ¾ÏÈ£ÈÇÏ´Â À¯Àü¹°ÁúÀÇ ÀϺκÐÀ̶ó´Â °³³äÀ¸·Î À̰ÍÀÌ À̸¥¹Ù 1°³ÀÇ À¯ÀüÀÚ 1°³ È¿¼Ò°¡¼³(one gene-one enzyme hypothesis)ÀÌ´Ù. Áï 1°³ÀÇ À¯ÀüÀÚ´Â 1°³ÀÇ È¿¼Ò¸¦ Á¦ÀÛÇϴµ¥ ÇÊ¿äÇÑ À¯ÀüÁ¤º¸¸¦ °¡Áø´Ù´Â °ÍÀÌ´Ù. ÇöÀç ÀÌ °¡¼³ÀÌ ¹Þ¾Æµé¿©Áö°í ÀÖ´Ù. |
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| ¿µ¹® | family therapy | ÇÑ±Û | °¡Á·¿ä¹ý |
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| ¼³¸í | °¡Á·À» Ä¡·á ´ë»óÀ¸·Î ÇÏ´Â ½É¸®¿ä¹ý ÁßÀÇ Çϳª. °¡Á·ÁßÀÇ ¹®Á¦´Â ¹®Á¦¸¦ °¡Áø °³Àθ¸ÀÌ ¾Æ´Ï¶ó ¹®Á¦ °¡Á·À» ´ë»óÀ¸·Î ÇØ°áÇØ ³ª°¥ Çʿ䰡 ÀÖ´Ù´Â ÀνÄÀ» ¹ÙÅÁÀ¸·Î ÇÏ¿© °¡Á· ÀüüÀÇ ½É¸®Àû ¼º¼÷À» ¸ñÇ¥·Î ÇÑ ¿ä¹ýÀÌ´Ù. Å©°Ô ³ª´©¾î °¡Á· ÁßÀÇ Æ¯Á¤ÀÎÀ» ´ë»óÀ¸·Î ÇÏ¿© °¢°¢ ´Ù¸¥ µ¶¸³µÈ Ä¡·á¸¦ ÇÏ´Â º´Çà½É¸®¿ä¹ý°ú °¡Á· Àüü¸¦ µ¿½Ã ¸éÁ¢ÇÏ´Â ¹æ¹ýÀ» ÁÖ·Î ÇÏ´Â ÇÕµ¿°¡Á·¿ä¹ýÀÌ Àִµ¥, ƯÈ÷ ÈÄÀÚ¸¦ °¡¸®ÄÑ °¡Á·¿ä¹ý À̶ó°í ÇÏ´Â °æ¿ì°¡ ¸¹´Ù. |
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| ¿µ¹® | intracavitary therapy | ÇÑ±Û | °³»¿ä¹ý |
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| ¼³¸í | ü°³», Áï ÀÔ¾È, ÄÚ¾È, Àεΰ, ½Äµµ, °ðâÀÚ, Áú, Àڱøñ, ¹æ±¤ µîÀÇ ³»°¿¡, ¶§·Î´Â º´ÅÍ¿¡ ÀÇÇØ »ý±ä °øµ¿³»¿¡ ¹æ»ç¼±À» »ðÀÔÇØ¼ Ä¡·áÇÏ´Â °ÍÀ» ¸»ÇÑ´Ù. ÁÖ·Î Á¾¾çÀÇ Ä¡·á¸¦ ¸ñÀûÀ¸·Î ÇÑ´Ù. |
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| ¿µ¹® | hyperbaric oxygenation therapy | ÇÑ±Û | °í¾Ð»ê¼Ò¿ä¹ý |
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| ¼³¸í | ´ë±â¾Ðº¸´Ù ³ôÀº ±â¾Ðȯ°æÀ» ÀΰøÀûÀ¸·Î ¸¸µé¾î ±× ¾È¿¡¼ °í³óµµÀÇ »ê¼Ò¸¦ ÈíÀÔ½ÃŰ´Â ¿ä¹ý. Çѱ¹¿¡¼ ¿¬Åº°¡½º·Î ´ëÇ¥µÇ´Â ÀÏ»êÈź¼ÒÀÇ ±Þ¼ºÁßµ¶ÀÇ Ä¡·á¿¡ ¸¹ÀÌ ÀÌ¿ëµÈ °ÍÀ¸·Î, º¸Åë 3´ë±â¾Ð Á¤µµ·Î °¡¾ÐµÈ °í¾Ð»ê¼Ò½ÇÀ̳ª °í¾Ð»ê¼ÒÅÊÅ© ¼Ó¿¡ ȯÀÚ¸¦ ³õ°í Àü½Å¿¡ »ê¼Ò¸¦ ÈíÀÔ½ÃŲ´Ù. °í¾Ð½ÇÀº Å©°í ÀÛÀº ¿©·¯ °¡Áö°¡ ÀÖÀ¸¸ç, ±¸Á¶»ó 1½Ç½Ä-2½Ç½Ä-´Ù½Ç½ÄÀÌ ÀÖ´Ù. °¡¾Ð °¡½ºÀÇ Á¾·ù¿¡´Â »ê¼Ò-°ø±â-È¥ÇÕ °¡½ºµîÀÌ ÀÖ°í, 2~3 ´ë±â¾Ð ¶Ç´Â ±× ÀÌ»óÀÇ °í¾Ð ȯ°æÀ» ¸¸µç´Ù. ÀÓ»óÀûÀ¸·Î ÀÀ¿ë¹üÀ§°¡ ³Ð¾î¼ ±â°èÀû È¿°ú¿¡ ÀÇÇÏ¿© Àá¼öºÎº´À̳ª âÀÚ°ü¸¶ºñ¿¡ ÀÇÇÑ Ã¢ÀÚÆó»ö Ä¡·á µî¿¡ À¯È¿Çϰí, °¡½º±ËÀú µîÀÇ ¹«»ê¼Ò¼º ¼¼±Õ°¨¿°¿¡¼µµ ÀÌ¿ëµÈ´Ù. ¶Ç »ê¼Ò¿î¹ÝÈ¿°ú¿¡ ÀÇÇÏ¿© ÀÏ»êÈź¼Ò-½É±Ù°æ»ö-³ú»öÀüÁõ-ÃâÇ÷¼îÅ©¿¡ ÀÇÇÑ ±Þ¼ºÀÇ Á¶Á÷»ê¼Ò°áÇÌÀÇ Ä¡·á¿¡ À¯È¿ÇÏ´Ù. ¶Ç ¾ÏÀÇ ¹æ»ç¼±¿ä¹ý¿¡ º´¿ëÇϸé ÀÌ ¿ä¹ýÀ¸·Î ¾Ï¼¼Æ÷ÀÇ ºÐ¿ÀÌ ¿Õ¼ºÇØÁ®, ¼¼Æ÷ºÐ¿ ÁßÀÎ ¼¼Æ÷¿¡ ¹æ»ç¼±À» Á¶»çÇÔÀ¸·Î½á ºÐ¿´É·ÂÀ» ¾ø¾Ö´Â µ¥ À¯È¿ÇÏ¿© °í¾Ð»ê¼ÒÈíÀÔÁ¶»ç¹ýÀ̶ó°í ÇÑ´Ù. |
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| ECG | Electro-Cardio-Graphy(-Gram); ½ÉÀüµµ = EKG 1. Conducting System Structu... |
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| CT | calcitonin; calf testis; cardiac tamponade; cardiothoracic [ratio]; carotid tracing; carpal tunnel; ... |
| IT | immunological test; immunotherapy; implantation test; individual therapy; information technology; in... |
| MT | magnetization transfer; malaria therapy; malignant teratoma; mammary tumor; mammilothalamic tract; m... |
| GT | gait training; galactosyl transferase; gastrostomy; generation time; genetic therapy; gingiva treatm... |
| GL | germ line |
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| GDEPT | Gene directed enzyme prodrug therapy |
| WGA | 125I-Wheat germ agglutinin |
| EG | Embryonic germ |
| EGCT | Extragonadal germ cell tumors |
| germ line gene therapy | The repair or replacement of a defective gene within the gamete-forming tissues, which produces an inheritable change in an organisms genetic constitution. (09 Oct 1997) |
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| germ line | A group of cells in most multicellular animals which give rise to the reproductive cells. The genome of the animal as contained in these cells, along with any mutations which might arise in them (germinal mutations), can be passed on to offspring. Also can refer to the appearance and conditions of the genome in the germ cells which may be different from within the somatic cells. The development of a germ cell as originating from a cell in a zygote. (09 Oct 1997) |
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| germ-line mutation | Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not. (12 Dec 1998) |
| germ line transformation | Micro injection of foreign DNA into an early embryo, so that it becomes incorporated into the germ line of the individual and thus stably inherited in subsequent generations of transgenic organisms. Typically, the DNA would be a reporter gene or cDNA in a vector such as a transposon, that might also carry a visible marker gene such as eye or coat colour), so that successful transformation could readily be detected. (18 Nov 1997) |
| gene therapy | <molecular biology> Treatment of a disease caused by malfunction of a gene, by stably transfecting the cells of the organism with the normal gene. (18 Nov 1997) |
| human gene therapy | <molecular biology, technique> Insertion of normal DNA directly into cells to correct a genetic defect. (09 Oct 1997) |
| somatic cell gene therapy | The repair or replacement of a defective gene within somatic tissue. (09 Oct 1997) |
| therapy, gene | Insertion of normal DNA directly into cells to correct a genetic defect. Gene therapy is the treatment of disease by replacing, altering, or supplementing a gene responsible for the disease. In gene therapy for cancer, for example, researchers are trying to bolster the body's natural capacity to combat cancer and make the tumour more sensitive to other kinds of therapy. Gene therapy, still in its early stages, holds great promise for the treatment of many diseases. (12 Dec 1998) |
| germ | 1. <biology> That which is to develop a new individual; as, the germ of a foetus, of a plant or flower, and the like; the earliest form under which an organism appears. "In the entire process in which a new being originates . Two distinct classes of action participate; namely, the act of generation by which the germ is produced; and the act of development, by which that germ is evolved into the complete organism." (Carpenter) 2. That from which anything springs; origin; first principle; as, the germ of civil liberty. <biology> Disease germ, the theory that living organisms can be produced only by the evolution or development of living germs or seeds. See Biogenesis, and Abiogenesis. As applied to the origin of disease, the theory claims that the zymotic diseases are due to the rapid development and multiplication of various bacteria, the germs or spores of which are either contained in the organism itself, or transferred through the air or water. See Fermentation theory. Origin: F. Germe, fr. L. Germen, germinis, sprout, but, germ. Cf. Germen, Germane. Source: Websters Dictionary (01 Mar 1998) |
| germ cell | Cell specialised to produce haploid gametes. The germ cell line is often formed very early in embryonic development. (18 Nov 1997) |
| germ cells | The reproductive cells in multicellular organisms. (12 Dec 1998) |
| germ cell tumour | A type of brain tumour. (12 Dec 1998) |
| germ-free animal | An animal which has no microorganisms whatsoever living in or on it. An animal which was born and raised in an isolated environment with no microorganisms in it, such as within a germ-free isolator. (09 Oct 1997) |
| germ-free isolator | A chamber which has absolutely no microorganisms whatsoever living in it, where a germ-free animal can be born and raised. An artificial barrier surrounding a living facility for germ-free animals, which keeps out all microorganisms. (09 Oct 1997) |
| germ-free life | Animals not contaminated by or associated with any foreign organisms. (12 Dec 1998) |
| germ layer | <embryology> A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. Diploblastic organisms (e.g. Coelenterates) have two layers, ectoderm and endoderm, triploblastic organisms (all higher animal groups) have mesoderm between these two layers. Germ layers become distinguishable during late blastula/early gastrula stages of embryogenesis and each gives rise to a characteristic set of tissues, the ectoderm to external epithelia and to the nervous system for example: although some tissues contain elements derived from two layers. (18 Nov 1997) |
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