| ¿µ¹® | tolerance | ÇÑ±Û | ³»¼º, °ßµõ |
|---|---|---|---|
| ¼³¸í | 1. ºñÁ¤»óÀûÀ¸·Î ´ë·®ÀÇ ¾à¹°¿¡ ´ëÇØ µ¶¼º¿µÇâÀ» ¹ÞÁö ¾Ê°í °ßµð¸ç ¶ÇÇÑ ÀÏÁ¤·®ÀÇ ¾à¹°ÀÇ Áö¼ÓÀûÀÎ »ç¿ë¿¡ ´ëÇØ¼ È¿°úÀÇ °¨¼Ò¸¦ ³ªÅ¸³»´Â ´É·Â. 2. ¸é¿ªÇÐÀûÀ¸·Î Ç׿øÆ¯ÀÌÀûÀÎ ¹«¹ÝÀÀ »óÅÂ. |
||
| ¿µ¹® | genetic engineering | ÇÑ±Û | À¯Àü°øÇÐ |
|---|---|---|---|
| ¼³¸í | 1. À¯ÀüÀÚÀÇ ÇÕ¼ºÀ̳ª º¯Çü µûÀ§¸¦ ¿¬±¸ÇÏ´Â Çй®. ÀÀ¿ë À¯ÀüÇÐÀÇ ÇÑ ºÐ¾ß·Î, º´ÀÇ Ä¡·á³ª ÀÌ·Î¿î »ê¹°ÀÇ ´ë·® »ý»êÀ» ¸ñÀûÀ¸·Î ÇÑ´Ù. 2. »ý¹°ÀÇ À¯ÀüÀÚ¸¦ ÀΰøÀûÀ¸·Î °¡°øÇÏ¿© Àΰ£¿¡°Ô ÇÊ¿äÇÑ ¹°ÁúÀ» ´ë·®À¸·Î °ª½Î°Ô ¾ò´Â ±â¼ú. 1970³â´ë¿¡ µé¾î¼¸é¼ °æÀÌÀûÀÎ °úÇбâ¼úÀÇ Çϳª·Î Å« ÁÖ¸ñÀ» ²ø°í ÀÖÀ¸¸ç, ÀÌ ºÐ¾ß¿¡´Â ÀçÁ¶ÇÕ DNA±â¼ú-¼¼Æ÷À¶ÇÕ±â¼ú ¹× ÇÙġȯ±â¼ú µîÀÌ ÀÖ´Ù. ÀçÁ¶ÇÕ DNA ±â¼ú¿¡ ÀÇÇÏ¿© ÀΰøÀûÀ¸·Î ÀçÁ¶ÇÕÀ¯ÀüÀÚ¸¦ ¸¸µç ÃÖÃÊÀÇ º¸°í´Â 1972³â Àè½¼ µîÀÌ ÇÏ¿´°í, ÀΰøÀû ÀçÁ¶ÇÕÀ¯ÀüÀÚ¸¦ ¼÷ÁÖ¼¼Æ÷¿¡¼ ÇüÁúÀ» ¹ßÇö½ÃŰ´Â µ¥ ÃÖÃÊ·Î ¼º°øÇÑ °ÍÀº 1973³â F. J. ÄÚº¥ µîÀÌ´Ù. ÀÌ ÀçÁ¶ÇÕ DNA ±â¼úÀº ¼¼±ÕÆÄÁö, Çö󽺹̵忡 °üÇÑ ¿¬±¸¿Í DNA¿¡ ÀÛ¿ëÇÏ´Â È¿¼Òµé, ƯÈ÷ Á¦ÇÑÈ¿¼Ò¿Í DNA ¿¬°áÈ¿¼Ò¿¡ °üÇÑ ¿¬±¸¿¡ ÀÇÁ¸ÇÏ¿´´Ù. À¯Àü°øÇÐÀÇ ¹ßÀüÀº ¿ì¸® ¼¼°è¸¦ ¹Ù²Ü ¼ö ÀÖÀ» °ÍÀ¸·Î ³»´Ùº¸°í ÀÖ´Ù. ¾ÏÀ» Á¦¾ÐÇÏ°í ³ëȸ¦ ¹æÁöÇÒ ¼ö ÀÖ¾î À¯Àü°øÇÐÀº °á±¹ ¿À´ÃÀÇ Àΰ£ÀÌ ¾È°í ÀÖ´Â ¿¡³ÊÁö-½Ä·®-ÀÇ·á µîÀÇ ¹®Á¦¸¦ ÇØ°áÇØ ÁÙ ¼ö ÀÖ´Â °¡´É¼ºÀ» Áö´Ñ´Ù. ÀÌ ¶§¹®¿¡ À¯Àü°øÇÐÀº ¡®Á¦3ÀÇ »ê¾÷Çõ¸í¡¯À̶ó°í ÇÒ ¼ö ÀÖ°í, µû¶ó¼ ±× °³¹ßÀ» À§ÇÏ¿© ¿Â ¼¼°èÀÇ ±â¾÷µéÀÌ ÀÌÀÇ ¿¬±¸°³¹ß¿¡ Âø¼öÇÏ°í ±¹°¡µéµµ Àü·«±â¼ú·Î ´Ù·ç¾î ÁýÁ¢ À°¼º¿¡ ¹ÚÂ÷¸¦ °¡Çϰí ÀÖ´Ù. ¿ì¸®³ª¶ó¿¡¼µµ 1982³âºÎÅÍ À¯Àü°øÇÐ ºÐ¾ß¸¦ ±¹°¡°¡ À°¼ºÇØ¾ß ÇÒ Æ¯Á¤¿¬±¸ ºÐ¾ß·Î ÁöÁ¤Çϰí ÀÖ´Ù. |
||
| ¿µ¹® | genetic code | ÇÑ±Û | À¯ÀüºÎÈ£ |
|---|---|---|---|
| ¼³¸í | ±æ°Ô ´Ã¾î¼ ÀÖ´Â DNA»ç½½ÀÇ À¯ÀüÁ¤º¸°¡ °¢°¢ÀÇ ¾Æ¹Ì³ë»ê¿¡ ´ëÀÀÇÏ¿© ´Ü¹éÁúÀÇ ÇÕ¼º¿¡ »ç¿ëµÉ ¼ö ÀÖ°Ô ÀÐÇôÁö´Â ¹æ¹ý. DNA ºÐÀÚ´Â °¢°¢ÀÇ Deoxyribonucleotide°¡ ¿¬°áµÇ¾î¼ ÀÌ·ç´Â ±¸Á¶ÀÌ´Ù. ÀÌDeoxyribonucleolide´Â ´ç, Àλê, ±×¸®°í ¿°±â·Î ÀÌ·ç¾îÁ® ÀÖ´Ù. ´ç°ú ÀλêÀº °¢°¢ÀÇ Deoxyribonucleotide°¡ ¿¬°áµÇ°Ô À¯ÁöÇØÁÖ´Â ¿ªÇÒÀ» ÇÏ°í ¿°±â°¡ À¯ÀüÁ¤º¸¸¦ °¡Áö°í ÀÖÀ¸¸ç ÀÌ ¿°±âÀÇ ¹è¿ÀÌ À¯ÀüÁ¤º¸ Áï ´Ü¹éÁúÀÇ ÇÕ¼º¿¡ ÇÊ¿äÇÑ Á¤º¸¸¦ °¡Áö°í ÀÖ´Ù. DNA¸¦ ÀÌ·ç´Â ¿°±â´Â 4°³·Î ¾Æµ¥´Ñ(adenine), ±¸¾Æ´Ñ(guanine), Ƽ¹Î(thymine), ½ÃÅä½Å(cytosine)ÀÇ 4°¡ÁöÀÌ´Ù. 4°³ÀÇ ¿°±â°¡ ¼¯¿©ÀÖ´Â ¹è¿À» ÇÑ °³ÀÇ ´Ü¹éÁú·Î ÇÕ¼ºÀ» Çϱâ À§Çؼ´Â ÀÌ ¹è¿À» ÇØµ¶ÇÏ´Â ¹æ¹ýÀÌ ÀÖ¾î¾ß ÇÑ´Ù. Áï ±× ¹æ¹ýÀº 3°³ÀÇ ¿°±âÀÇ ¹è¿À» ÇϳªÀÇ ¾Æ¹Ì³ë»ê¿¡ ´ëÀÀ½ÃÄѼ °¢ ¾Æ¹Ì³ë»êÀÇ ¼¿À» Á¤ÇÏ°í ´Ü¹éÁúÀ» ¸¸µå´Â °ÍÀÌ´Ù. ¿¹¸¦ µé¸é cytosine-cytosine-cytosineÀ̶ó´Â ¹è¿Àº prolineÀ̶ó´Â ´Ü¹éÁúÀ» ÀǹÌÇÏ´Â °ÍÀ¸·Î ÀÐÇôÁö°Ô µÈ´Ù. ÀÌ·¸°Ô ¾Æ¹«·± ±ÔÄ¢ÀÌ ¾ø´Â °Í °°Àº ¿°±â¼¿À» ÇϳªÀÇ ¾Æ¹Ì³ë»ê°ú ´ëÀÀ½ÃÄѼ Àд ¹æ¹ýÀÌ À¯ÀüºÎÈ£ÀÌ´Ù. |
||
| ¿µ¹® | glucose tolerance test | ÇÑ±Û | Æ÷µµ´ç°ßµõ°Ë»ç |
|---|---|---|---|
| ¼³¸í | Æ÷µµ´ç°ßµõ °Ë»ç¶õ ´ç´¢º´ÀÇ Áø´Ü¿¡ »ç¿ëµÇ´Â °Ë»ç·Î ´çÀ» ü³»¿¡ Åõ¿©ÇÏ°í ½Ã°£ º°·Î Ç÷¾×À» äÃëÇÏ¿© Ç÷´çÀÇ ³óµµ¸¦ Àç¾î¼ °íÇ÷´ç ¿©ºÎ¸¦ Á¶»çÇÏ´Â °Ë»çÀÌ´Ù. ÁÖ·Î °æ±¸Æ÷µµ´ç°ßµõ°Ë»ç(oral glucose tolerance test)¸¦ ¸¹ÀÌ Çϴµ¥ À̰ÍÀº 10~16½Ã°£ÀÇ ±Ý½Ä ÈÄ¿¡ äÇ÷À» Çѹø Çѵڿ¡ µµ´ç 75gÀ» 250~300mLÀÇ ¹°¿¡ ³ì¿© 5ºÐ¿¡ °ÉÃļ ¸¶½Ã°Ô ÇÏ°í ¸Å½Ã°£ º°·Î äÇ÷À» ÇÏ¿© Ç÷´çÀÇ ³óµµ¸¦ ýũÇÑ´Ù. °øº¹½Ã¿¡ Á¤¸Æ¿¡¼ äÇ÷ÇÏ¿© ÃøÁ¤ÇÑ Ç÷´çÀÌ 140mg/dLÀÌ»óÀ̰ųª Æ÷µµ´ç°ßµõ °Ë»ç 2½Ã°£ÈÄÀÇ Ç÷´çÀÌ 200mg/dLÀÌ»óÀÏ °æ¿ì¿¡´Â ´ç´¢º´À¸·Î Áø´ÜÀ» ÇÑ´Ù. ±×·¯³ª ÀÌ °Ë»ç¸¦ ½Ç½ÃÇÒ °æ¿ì¿¡ ÁÖÀÇÇØ¾ß ÇÒ Á¡Àº °Ë»çÀü 3Àϰ£ ÇÏ·ç¿¡ 150gÀÌ»óÀÇ Åº¼öȹ°À» ¼·ÃëÇØ¾ß ÇÑ´Ù´Â °Í°ú °Ë»çµµÁß¿¡ ¿îµ¿, Èí¿¬ µîÀ» ÇÏÁö ¾Ê¾Æ¾ß ÇÑ´Ù´Â °ÍÀÌ´Ù. |
||
| ¿µ¹® | radiation dose | ÇÑ±Û | ¹æ»ç¼±·® |
|---|---|---|---|
| ¼³¸í | ¹æ»ç¼±Á¶»çÀÇ Á¤µµ. ¹æ»ç¼±»ý¹°ÇÐÀ̳ª ÀÎüÀÇ ¹æ»ç¼±¹æÈ£¿¡¼´Â Àü¸®¹æ»ç¼±ÀÇ ¾ç, Áï ¼±·®ÀÌ ¹®Á¦°¡ µÈ´Ù. ¹æ»ç¼±·®¿¡¼µµ ±¹Á¦´ÜÀ§°è(SI)°¡ ä¿ëµÇ¾î ±¹Á¦¹æ»ç¼±¹æÈ£À§¿øÈ¸(ICRP)ÀÇ ±Ç°í¿¡ µû¶ó¼ ´ÙÀ½ÀÇ ¿©·¯ ´ÜÀ§°¡ ³Î¸® »ç¿ëµÈ´Ù. ¨ç Èí¼ö¼±·®(absorbed dose). ¹°ÁúÀÇ ´ÜÀ§Áú·®ÀÌ ¹æ»ç¼±¿¡ ÀÇÇØ ¹Þ¾ÆµéÀÌ´Â ¿¡³ÊÁö. ÀÌ ´ÜÀ§´Â ¹æ»ç¼± ¹× ¹°ÁúÀÇ Á¾·ù°¡ ¾î¶°ÇÑ °ÍÀÌ´õ¶óµµ »ç¿ëÇÒ ¼ö ÀÖ´Ù. ±¹Á¦´ÜÀ§´Â J/kgÀ̸ç À̰Ϳ¡ °íÀ¯ÇÑ ¸íĪÀ¸·Î ±×·¹ÀÌ(gray, ±âÈ£ Gy)°¡ ºÎ¿©µÈ´Ù. 1Gy=100¶óµå(rad). ¨è Á¶»ç¼±·®(exposure) ¶Ç´Â °øÁß¼±·®. X¼± ¶Ç´Â ¥ã¼±¿¡ ÇÑÇØ¼ »ç¿ëµÈ´Ù. ±¹Á¦´ÜÀ§´Â C/kg. ¨é ¼±·®´ç·®(dose equivalent). ¹æ»ç¼±¹æÈ£¸¦ À§ÇØ »ç¿ëµÇ´Â ¾ç. ±âÈ£´Â H. H´Â ¹æ»ç¼±ÀÇ Á¾·ù¿Í ¿¡³ÊÁö¿¡ ÀÇÇØ »ýü¿¡ ÁÖ´Â È¿°ú¸¦ º¸Á¤ÇÏ´Â ¼±Áú°è¼ö(Q)¿Í ±× ¹ÛÀÇ ÀÎÀÚ(¿¹¸¦ µé¸é ¼±·®·ü, ¹æ»ç¼ºµ¿À§¿ø¼Ò¿¡ ÀÇÇÑ ³»ºÎÇÇÆø½Ã¿¡´Â ±× ÇÙÁ¾ÀÇ Ã¼³»ºÐÆ÷ µî)¿¡ ±Ù°ÅÇÑ º¸Á¤°è¼ö(N)¸¦ Èí¼ö¼±·®(D)¿¡ °öÇÑ °Í, Áï H=D-Q-N. ¶ÇÇÑ DÀÇ ´ÜÀ§¸¦ Gy ¶Ç´Â rad·Î Ç¥½ÃÇÏ¿´À» ¶§ HÀÇ ´ÜÀ§¸¦ °¢°¢ ½Ãº£¸£Æ®(sievert, ±âÈ£ Sv) ¹× ·½(rem)À̶ó°í ÇÑ´Ù. µû¶ó¼ 1 Sv=102rem. ÀϹÝÀûÀ¸·Î ´ÜÀ§½Ã°£´çÀÇ ¼±·®À» ¼±·®·ü(dose rate)À̶ó°í ÇÑ´Ù. |
||
| ID | identification; iditol dehydrogenase; immunodeficiency; immunodiffusion; immunoglobulin deficiency; ... |
|---|---|
| TD | tabes dorsalis; tardive dyskinesia; T-cell dependent; temporary disability; terminal device; tetanus... |
| GT | gait training; galactosyl transferase; gastrostomy; generation time; genetic therapy; gingiva treatm... |
| AITT | arginine insulin tolerance test; augmented insulin tolerance test |
| ATT | arginine tolerance test; aspirin tolerance time |
| GAERS | Genetic Absence Epilepsy Rat from Strasbourg |
|---|---|
| GA | Genetic Algorithm |
| GH | Genetic Hemochromatosis |
| GSE | genetic suppressor element |
| PGD | Pre-implantation Genetic Diagnosis |
| high dose tolerance | The induction of tolerance by exposure to high doses of antigen. (05 Mar 2000) |
|---|---|
| immunologic high dose tolerance | Induction of tolerance by exposure to large amounts of protein antigens. (05 Mar 2000) |
| tolerance dose | The largest dose of a remedy that can be accepted without the production of injurious symptoms. (05 Mar 2000) |
| acoustic tolerance | The maximum sound pressure level that can be experienced without producing pain or permanent defect of hearing in a normal individual. (05 Mar 2000) |
| bile acid tolerance test | A sensitive test of hepatic dysfunction; following oral administration of labelled or unlabelled bile acid, the measured fractional disappearance rate or 10-minute retention is measured. (05 Mar 2000) |
| galactose tolerance test | A liver function test, based on the ability of the liver to convert galactose to glycogen, measured by the rate of excretion of galactose following ingestion or intravenous injection of a known amount; normally, less than 3 g appear in the urine within 5 hours after the ingestion of 40 g. (05 Mar 2000) |
| radiation tolerance | The ability of some cells or tissues to withstand ionizing radiation without serious injury. Tolerance depends on the species, cell type, and physical and chemical variables, including radiation-protective agents and radiation-sensitizing agents. (12 Dec 1998) |
| pain tolerance | The greatest intensity of painful stimulation that an individual is able to tolerate. (05 Mar 2000) |
| gamma-tolerance | The tolerance of a person or a piece of equipment to forces that develop as a result of acceleration or deceleration. (05 Mar 2000) |
| vibration tolerance | The maximum vibratory or oscillatory movements that an individual can experience and bear without pain; the limit of tolerance is a function of amplitude and frequency of the vibration and varies with the direction of application. (05 Mar 2000) |
| glucose tolerance factor | A water-soluble complex containing chromium needed for normal glucose tolerance. (05 Mar 2000) |
| glucose tolerance test | <chemical pathology, investigation> A special test where the blood glucose is measure in intervals after a glucose-rich meal is taken, a test used for diagnosing diabetes. (27 Sep 1997) |
| work schedule tolerance | Physiological or psychological effects of periods of work which may be fixed or flexible such as flexitime, work shifts, and rotating shifts. (12 Dec 1998) |
| cross tolerance | <pharmacology> The resistance to one or several effects of a compound as a result of tolerance developed to a pharmacologically similar compound. (05 Mar 2000) |
| xylose tolerance test | <investigation> This test measures the intestine's ability to absorb the simple sugar, D-xylose. This is an indicator for whether or not nutrients are being absorbed properly in the intestine. This test is often used to evaluate persistent diarrhoea, weight loss, malnutrition and cases of suspected malabsorption. Abnormal results may be seen in the following conditions: Crohn's disease, Giardiasis, hookworm infestation, radiation enteritis, celiac sprue, viral gastroenteritis and Whipple's disease. (27 Sep 1997) |
Á¦Ç°¸í |
ÆÇ¸Å»ç |
º¸ÇèÄÚµå | ¼ººÐ/ÇÔ·® | ±¸ºÐ/º¸Çè±Þ¿© |
|---|
Á¦Ç°¸í |
ÆÇ¸Å»ç |
º¸ÇèÄÚµå | ¼ººÐ/ÇÔ·® | ±¸ºÐ/º¸Çè±Þ¿© |
|---|