| ¿µ¹® | genetic engineering | ÇÑ±Û | À¯Àü°øÇÐ |
|---|---|---|---|
| ¼³¸í | 1. À¯ÀüÀÚÀÇ ÇÕ¼ºÀ̳ª º¯Çü µûÀ§¸¦ ¿¬±¸ÇÏ´Â Çй®. ÀÀ¿ë À¯ÀüÇÐÀÇ ÇÑ ºÐ¾ß·Î, º´ÀÇ Ä¡·á³ª ÀÌ·Î¿î »ê¹°ÀÇ ´ë·® »ý»êÀ» ¸ñÀûÀ¸·Î ÇÑ´Ù. 2. »ý¹°ÀÇ À¯ÀüÀÚ¸¦ ÀΰøÀûÀ¸·Î °¡°øÇÏ¿© Àΰ£¿¡°Ô ÇÊ¿äÇÑ ¹°ÁúÀ» ´ë·®À¸·Î °ª½Î°Ô ¾ò´Â ±â¼ú. 1970³â´ë¿¡ µé¾î¼¸é¼ °æÀÌÀûÀÎ °úÇбâ¼úÀÇ Çϳª·Î Å« ÁÖ¸ñÀ» ²ø°í ÀÖÀ¸¸ç, ÀÌ ºÐ¾ß¿¡´Â ÀçÁ¶ÇÕ DNA±â¼ú-¼¼Æ÷À¶ÇÕ±â¼ú ¹× ÇÙġȯ±â¼ú µîÀÌ ÀÖ´Ù. ÀçÁ¶ÇÕ DNA ±â¼ú¿¡ ÀÇÇÏ¿© ÀΰøÀûÀ¸·Î ÀçÁ¶ÇÕÀ¯ÀüÀÚ¸¦ ¸¸µç ÃÖÃÊÀÇ º¸°í´Â 1972³â Àè½¼ µîÀÌ ÇÏ¿´°í, ÀΰøÀû ÀçÁ¶ÇÕÀ¯ÀüÀÚ¸¦ ¼÷ÁÖ¼¼Æ÷¿¡¼ ÇüÁúÀ» ¹ßÇö½ÃŰ´Â µ¥ ÃÖÃÊ·Î ¼º°øÇÑ °ÍÀº 1973³â F. J. ÄÚº¥ µîÀÌ´Ù. ÀÌ ÀçÁ¶ÇÕ DNA ±â¼úÀº ¼¼±ÕÆÄÁö, Çö󽺹̵忡 °üÇÑ ¿¬±¸¿Í DNA¿¡ ÀÛ¿ëÇÏ´Â È¿¼Òµé, ƯÈ÷ Á¦ÇÑÈ¿¼Ò¿Í DNA ¿¬°áÈ¿¼Ò¿¡ °üÇÑ ¿¬±¸¿¡ ÀÇÁ¸ÇÏ¿´´Ù. À¯Àü°øÇÐÀÇ ¹ßÀüÀº ¿ì¸® ¼¼°è¸¦ ¹Ù²Ü ¼ö ÀÖÀ» °ÍÀ¸·Î ³»´Ùº¸°í ÀÖ´Ù. ¾ÏÀ» Á¦¾ÐÇÏ°í ³ëȸ¦ ¹æÁöÇÒ ¼ö ÀÖ¾î À¯Àü°øÇÐÀº °á±¹ ¿À´ÃÀÇ Àΰ£ÀÌ ¾È°í ÀÖ´Â ¿¡³ÊÁö-½Ä·®-ÀÇ·á µîÀÇ ¹®Á¦¸¦ ÇØ°áÇØ ÁÙ ¼ö ÀÖ´Â °¡´É¼ºÀ» Áö´Ñ´Ù. ÀÌ ¶§¹®¿¡ À¯Àü°øÇÐÀº ¡®Á¦3ÀÇ »ê¾÷Çõ¸í¡¯À̶ó°í ÇÒ ¼ö ÀÖ°í, µû¶ó¼ ±× °³¹ßÀ» À§ÇÏ¿© ¿Â ¼¼°èÀÇ ±â¾÷µéÀÌ ÀÌÀÇ ¿¬±¸°³¹ß¿¡ Âø¼öÇÏ°í ±¹°¡µéµµ Àü·«±â¼ú·Î ´Ù·ç¾î ÁýÁ¢ À°¼º¿¡ ¹ÚÂ÷¸¦ °¡Çϰí ÀÖ´Ù. ¿ì¸®³ª¶ó¿¡¼µµ 1982³âºÎÅÍ À¯Àü°øÇÐ ºÐ¾ß¸¦ ±¹°¡°¡ À°¼ºÇØ¾ß ÇÒ Æ¯Á¤¿¬±¸ ºÐ¾ß·Î ÁöÁ¤Çϰí ÀÖ´Ù. |
||
| ¿µ¹® | genetic code | ÇÑ±Û | À¯ÀüºÎÈ£ |
|---|---|---|---|
| ¼³¸í | ±æ°Ô ´Ã¾î¼ ÀÖ´Â DNA»ç½½ÀÇ À¯ÀüÁ¤º¸°¡ °¢°¢ÀÇ ¾Æ¹Ì³ë»ê¿¡ ´ëÀÀÇÏ¿© ´Ü¹éÁúÀÇ ÇÕ¼º¿¡ »ç¿ëµÉ ¼ö ÀÖ°Ô ÀÐÇôÁö´Â ¹æ¹ý. DNA ºÐÀÚ´Â °¢°¢ÀÇ Deoxyribonucleotide°¡ ¿¬°áµÇ¾î¼ ÀÌ·ç´Â ±¸Á¶ÀÌ´Ù. ÀÌDeoxyribonucleolide´Â ´ç, Àλê, ±×¸®°í ¿°±â·Î ÀÌ·ç¾îÁ® ÀÖ´Ù. ´ç°ú ÀλêÀº °¢°¢ÀÇ Deoxyribonucleotide°¡ ¿¬°áµÇ°Ô À¯ÁöÇØÁÖ´Â ¿ªÇÒÀ» ÇÏ°í ¿°±â°¡ À¯ÀüÁ¤º¸¸¦ °¡Áö°í ÀÖÀ¸¸ç ÀÌ ¿°±âÀÇ ¹è¿ÀÌ À¯ÀüÁ¤º¸ Áï ´Ü¹éÁúÀÇ ÇÕ¼º¿¡ ÇÊ¿äÇÑ Á¤º¸¸¦ °¡Áö°í ÀÖ´Ù. DNA¸¦ ÀÌ·ç´Â ¿°±â´Â 4°³·Î ¾Æµ¥´Ñ(adenine), ±¸¾Æ´Ñ(guanine), Ƽ¹Î(thymine), ½ÃÅä½Å(cytosine)ÀÇ 4°¡ÁöÀÌ´Ù. 4°³ÀÇ ¿°±â°¡ ¼¯¿©ÀÖ´Â ¹è¿À» ÇÑ °³ÀÇ ´Ü¹éÁú·Î ÇÕ¼ºÀ» Çϱâ À§Çؼ´Â ÀÌ ¹è¿À» ÇØµ¶ÇÏ´Â ¹æ¹ýÀÌ ÀÖ¾î¾ß ÇÑ´Ù. Áï ±× ¹æ¹ýÀº 3°³ÀÇ ¿°±âÀÇ ¹è¿À» ÇϳªÀÇ ¾Æ¹Ì³ë»ê¿¡ ´ëÀÀ½ÃÄѼ °¢ ¾Æ¹Ì³ë»êÀÇ ¼¿À» Á¤ÇÏ°í ´Ü¹éÁúÀ» ¸¸µå´Â °ÍÀÌ´Ù. ¿¹¸¦ µé¸é cytosine-cytosine-cytosineÀ̶ó´Â ¹è¿Àº prolineÀ̶ó´Â ´Ü¹éÁúÀ» ÀǹÌÇÏ´Â °ÍÀ¸·Î ÀÐÇôÁö°Ô µÈ´Ù. ÀÌ·¸°Ô ¾Æ¹«·± ±ÔÄ¢ÀÌ ¾ø´Â °Í °°Àº ¿°±â¼¿À» ÇϳªÀÇ ¾Æ¹Ì³ë»ê°ú ´ëÀÀ½ÃÄѼ Àд ¹æ¹ýÀÌ À¯ÀüºÎÈ£ÀÌ´Ù. |
||
| ALC | absolute lymphocyte count; acute lethal catatonia; aided living center; Alternative Lifestyle Checkl... |
|---|---|
| MLD | manual lymph drainage; median lethal dose; metachromatic leukodystrophy; minimal lesion disease; min... |
| AGA | accelerated growth area; allergic granulomatosis and angiitis; American Gastroenterological Associat... |
| Gen | genetics, genetic; genus |
| genet | genetic, genetics |
| GAERS | Genetic Absence Epilepsy Rat from Strasbourg |
|---|---|
| GA | Genetic Algorithm |
| GH | Genetic Hemochromatosis |
| GSE | genetic suppressor element |
| PGD | Pre-implantation Genetic Diagnosis |
| genetic lethal | A disorder that prevents effective reproduction by those affected; e.g., Klinefelter syndrome. (05 Mar 2000) |
|---|
| balanced lethal system | <genetics> A population with non-linked, recessive alleles of a gene, where an individual who has two copies of the recessive allele and is therefore homozygous is dead, while an individual who has only one copy of it, and one copy of a different allele (and is heterozygous) survives. (09 Oct 1997) |
|---|---|
| genes, lethal | Genes which result in the premature death of the organism; dominant lethal genes kill heterozygotes, whereas recessive lethal genes kill only homozygotes. (12 Dec 1998) |
| granuloma, lethal midline | A non-neoplastic disease of unknown aetiology beginning with inflammation, ulceration, and perforation of nose and palate and progressing to gradual destruction of midline facial structures. (12 Dec 1998) |
| chicken embryo lethal orphan virus | <virology> A virus with characteristics of adenovirus, and similar to quail bronchitis virus. Synonym: chicken embryo lethal orphan virus. (05 Mar 2000) |
| minimal lethal dose | <pharmacology> The minimal dose of a toxic substance or infectious agent that is lethal, as assayed in various experimental animals (e.g., the least amount of diphtheria toxin that, on an average, kills a 250-g guinea pig within 96 hours after subcutaneous inoculation). When followed by a subscript (generally "MLD50"), denotes the minimal dose that is lethal to a certain percentage (e.g., 50%) of animals so assayed, LD05. See: lethal dose. (05 Mar 2000) |
| clinical lethal | A disorder that culminates in premature death. (05 Mar 2000) |
| conditional-lethal mutant | A viral mutant that can replicate under some (permissive) conditions but not under other (restrictive or nonpermissive) conditions, the parent (wild type) strain being able to replicate under both conditions. See: suppressor-sensitive mutant, temperature-sensitive mutant. Synonym: conditional-lethal mutant. (05 Mar 2000) |
| conditionally lethal mutant | A viral mutant that can replicate under some (permissive) conditions but not under other (restrictive or nonpermissive) conditions, the parent (wild type) strain being able to replicate under both conditions. See: suppressor-sensitive mutant, temperature-sensitive mutant. Synonym: conditional-lethal mutant. (05 Mar 2000) |
| dominant lethal trait | Trait, expressed in the phenotype if present in the genotype, that precludes having descendants. All such cases are necessarily sporadic and must represent new mutations as the usual methods of classical genetics provide no means of demonstrating any genetic component whatsoever, except for tenuous arguments such as advanced paternal age. Molecular biology may help although the methods may be tedious; if there is an epistatic gene that may mask the trait, the logic is more tractable, though complex. (05 Mar 2000) |
| y-suppressed lethal gene | <genetics> In the fruit fly Drosophila, this is a recessive, lethal gene that kills XO flies but not normal XY male flies. (09 Oct 1997) |
| zygotic lethal gene | <genetics> A mutated or otherwise defective gene at embryonic or larval stages. (06 May 1997) |
| lethal | Deadly, fatal. Origin: L. Lethalis, from lethum = death (18 Nov 1997) |
| lethal coefficient | <microbiology> That concentration of disinfectant that kills bacteria at 20-25°C in the shortest period of time. (05 Mar 2000) |
| lethal dose | <pharmacology> The amount, or dosage, of a toxin necessary to cause death. (16 Mar 1998) |
| lethal dose 50 | <pharmacology> The amount, or dosage, of a toxin necessary to kill 50% of the experimental subjects. (16 Mar 1998) |
| genetic lethal |
A genetic disease that prevents fertility.
Ãâó: www.kumc.edu/gec/gloss.html
|
|---|
Á¦Ç°¸í |
ÆÇ¸Å»ç |
º¸ÇèÄÚµå | ¼ººÐ/ÇÔ·® | ±¸ºÐ/º¸Çè±Þ¿© |
|---|
Á¦Ç°¸í |
ÆÇ¸Å»ç |
º¸ÇèÄÚµå | ¼ººÐ/ÇÔ·® | ±¸ºÐ/º¸Çè±Þ¿© |
|---|