| dpdt | double-pole double-throw [switch] |
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| dpst | double-pole single-throw [switch] |
| SCS | Saethre-Chotzen syndrome; shared computer system; silicon-controlled switch; Society of Clinical Sur... |
| ASO | Arterial switch operation |
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| CSR | class switch recombination |
| S | switch |
| ISG | IFN stimulated genes |
| mdr | Multidrug resistance genes |
| genes, switch | Genes that cause the epigenotype (i.e., the interrelated developmental pathways through which the adult organism is realised) to switch to an alternate cell lineage-related pathway. Switch complexes control the expression of normal functional development as well as oncogenic transformation. (12 Dec 1998) |
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| arterial switch operation | Operation for complete transposition of the great arteries; the most common way to repair this defect consists of switching the aorta and pulmonary arteries and implanting the coronary arteries into the neoaorta (the original pulmonary artery). (05 Mar 2000) |
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| gene switch | <molecular biology> A situation in which a cell or organism stops expressing one gene orgene group and switches to expressing a different gene or group of genes. (09 Oct 1997) |
| class switch | Change in the isotype of antibody produced after a B-cell has encountered an antigen. (05 Mar 2000) |
| switch | 1. To strike with a switch or small flexible rod; to whip. 2. To swing or whisk; as, to switch a cane. 3. To trim, as, a hedge. 4. To turn from one railway track to another; to transfer by a switch; generally with off, from, etc.; as, to switch off a train; to switch a car from one track to another. 5. To shift to another circuit. Origin: Switched; Switching. 1. A small, flexible twig or rod. "Mauritania, on the fifth medal, leads a horse with something like a thread; in her other hand she holds a switch." (Addison) 2. A movable part of a rail; or of opposite rails, for transferring cars from one track to another. 3. A separate mass or trees of hair, or of some substance (at jute) made to resemble hair, worn on the head by women. 4. A mechanical device for shifting an electric current to another circuit. Safety switch, an arrangement of tracks whereby elevations otherwise insurmountable are passed. The track ascends by a series of zigzags, the engine running alternately forward and back, until the summit is reached. <physics> Switch board, a collection of switches in one piece of apparatus, so arranged that a number of circuits may be connected or combined in any desired manner. Switch grass. <botany> See Grass. Origin: Cf. OD. Swick a scourage, a whip. Cf. Swink, Swing. Source: Websters Dictionary (01 Mar 1998) |
| switch region | <molecular biology> The nucleotide sequences in heavy chain immunoglobulin genes located in the introns at the 5' end of each CH locus concerned with DNA recombination events that lead to changes in the type of heavy chain produced by a B-cell, for example IgM to IgG switching. These regions are highly conserved sequences. See: isotype switching. (19 Jan 1998) |
| immunoglobulin switch region | Site on a segment of a B-cell immunoglobulin heavy-chain gene where recombination or rearrangement can occur, expressed as isotype or allotype switching, maturation of immune response, or recombination of DNA molecules. It is found on genes encoding all five immunoglobulin heavy chains. (12 Dec 1998) |
| q-switch | <radiobiology> Optical switch used to rapidly change the Q of an optical resonator, utilised in the optical resonator of a laser to prevent lasing action until a high level of gain and energy storage are achieved in the laser medium. When the switch is triggered and rapidly increases the Q of the cavity, a stronger laser pulse is generated. See: oscillator. (09 Oct 1997) |
| breast cancer susceptibility genes | Inherited factors that predispose to breast cancer. Put otherwise, these genes make one more susceptible to the disease and so increase the risk of developing breast cancer. Two of these genes, BRCA1 and BRCA2, have been identified (and prominently publicised). Several other genes (those for the Li-Fraumeni syndrome, Cowden disease, Muir-Torre syndrome, and ataxia-telangiectasia) are also known to predispose to breast cancer. However, since all of these known breast cancer susceptibility genes together do not account for more than a minor fraction (1/5th at most) of breast cancer that clusters in families, it is clear that more breast cancer genes remain to be discovered. (12 Dec 1998) |
| cancer, breast, susceptibility genes | Inherited factors that predispose to breast cancer. Put otherwise, these genes make one more susceptible to the disease and so increase the risk of developing breast cancer. Two of these genes, BRCA1 and BRCA2, have been identified (and prominently publicised). Several other genes (those for the Li-Fraumeni syndrome, Cowden disease, Muir-Torre syndrome, and ataxia-telangiectasia) are also known to predispose to breast cancer. However, since all of these known breast cancer susceptibility genes together do not account for more than a minor fraction (1/5th at most) of breast cancer that clusters in families, it is clear that more breast cancer genes remain to be discovered. (12 Dec 1998) |
| genes | Located in the nucleus of the cell, genes contain hereditary information that is transferred from cell to cell. (09 Oct 1997) |
| genes, abl | Retrovirus-associated DNA sequences (abl) originally isolated from the abelson murine leukaemia virus (ab-mulv). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukaemia. (12 Dec 1998) |
| genes, apc | Tumour suppressor genes located in the 5q21 region on the long arm of chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (apc stands for adenomatous polyposis coli) and gardner's syndrome, as well as some sporadic colourectal cancers. (12 Dec 1998) |
| genes, arac | Regulatory genes which encode a cyclic AMP receptor protein required for l-arabinose utilization in e. Coli. It is an example of positive control or regulation of gene expression in the bacterial operon. (12 Dec 1998) |
| genes, archaeal | The genetic material of archaea. (12 Dec 1998) |
| genes, bacterial | The genetic material of bacteria. (12 Dec 1998) |
Synonyms : Switch Complexes, Switching Complexes, Complex, Switching, Complexes, Switch, Complexes, Switching, Gene, Switch, Switch Gene
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