| ISG | IFN stimulated genes |
|---|---|
| mdr | Multidrug resistance genes |
| stx | Shiga toxin genes |
| or genes | gene |
| rDNA | ribosomal DNA genes |
| genes, myc | Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumourigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8. (12 Dec 1998) |
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| myc | <oncogene> This proto-oncogene causes cancers (carcinomas and sarcomas) and is found in the avian myelocytomatosis virus. It has been identified in several avian tumours, and encodes a nuclear protein with a leucine zipper motif. If translocated, it can cause Burkitt's lymphoma, if amplified, it can cause lung, breast, and cervical carcinomas. It is found in both chickens and has an analogue in humans which is located on the long arm of chromosome 8. (24 Mar 1998) |
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| myc proteins | <molecular biology> Family of proteins involved in control of translation, have a C terminal basic helix loop helix zipper domain. Myc Max heterodimers specifically bind the sequence CACGTG with higher affinity than homodimers of either. (18 Nov 1997) |
| proto-oncogene proteins c-myc | Cellular DNA-binding proteins encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumourigenesis. (12 Dec 1998) |
| N myc | <oncogene> Oncogene, related to myc, found in neuroblastomas. (18 Nov 1997) |
| oncogene protein p55(v-myc) | Transforming protein coded by myc oncogenes. The v-myc protein has been found in several replication-defective avian retrovirus isolates which induce a broad spectrum of malignancies. (12 Dec 1998) |
| L myc | <oncogene> Relative of the myc proto-oncogene overexpressed in lung carcinoma. (18 Nov 1997) |
| breast cancer susceptibility genes | Inherited factors that predispose to breast cancer. Put otherwise, these genes make one more susceptible to the disease and so increase the risk of developing breast cancer. Two of these genes, BRCA1 and BRCA2, have been identified (and prominently publicised). Several other genes (those for the Li-Fraumeni syndrome, Cowden disease, Muir-Torre syndrome, and ataxia-telangiectasia) are also known to predispose to breast cancer. However, since all of these known breast cancer susceptibility genes together do not account for more than a minor fraction (1/5th at most) of breast cancer that clusters in families, it is clear that more breast cancer genes remain to be discovered. (12 Dec 1998) |
| cancer, breast, susceptibility genes | Inherited factors that predispose to breast cancer. Put otherwise, these genes make one more susceptible to the disease and so increase the risk of developing breast cancer. Two of these genes, BRCA1 and BRCA2, have been identified (and prominently publicised). Several other genes (those for the Li-Fraumeni syndrome, Cowden disease, Muir-Torre syndrome, and ataxia-telangiectasia) are also known to predispose to breast cancer. However, since all of these known breast cancer susceptibility genes together do not account for more than a minor fraction (1/5th at most) of breast cancer that clusters in families, it is clear that more breast cancer genes remain to be discovered. (12 Dec 1998) |
| genes | Located in the nucleus of the cell, genes contain hereditary information that is transferred from cell to cell. (09 Oct 1997) |
| genes, abl | Retrovirus-associated DNA sequences (abl) originally isolated from the abelson murine leukaemia virus (ab-mulv). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukaemia. (12 Dec 1998) |
| genes, apc | Tumour suppressor genes located in the 5q21 region on the long arm of chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (apc stands for adenomatous polyposis coli) and gardner's syndrome, as well as some sporadic colourectal cancers. (12 Dec 1998) |
| genes, arac | Regulatory genes which encode a cyclic AMP receptor protein required for l-arabinose utilization in e. Coli. It is an example of positive control or regulation of gene expression in the bacterial operon. (12 Dec 1998) |
| genes, archaeal | The genetic material of archaea. (12 Dec 1998) |
| genes, bacterial | The genetic material of bacteria. (12 Dec 1998) |
| genes, bcl-1 | The B-cell leukaemia/lymphoma-1 genes, associated with various neoplasms when overexpressed. Overexpression results from the t(11;14) translocation, which is characteristic of mantle zone-derived B-cell lymphomas. The human c-bcl-1 gene is located at 11q13 on the long arm of chromosome 18. (12 Dec 1998) |
Synonyms : L-myc Proto-Oncogenes, N-myc Proto-Oncogenes, c-myc Proto-Oncogenes, myc Oncogene, v-myc Oncogenes, Gene, L-myc, Gene, N-myc, Gene, c-myc, Gene, myc, Gene, v-myc, Genes, L-myc, Genes, N-myc, Genes, c-myc, Genes, v-myc, L myc Genes, L myc Proto Oncogenes, L-myc Gene
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