| 영문 | gene | 한글 | 유전자 |
|---|---|---|---|
| 설명 | 유전자는 길게 띠를 형성한 DNA분자의 일부분으로 한 가지 물질을 만드는데 필요한 모든 정보를 갖춘 기능적인 단위이다. 예를 들어 인슐린이라는 물질의 유전자라고 하면 사람의 세포내에 있는 긴 DNA 분자 중에서 인슐린이라는 물질을 만드는데 필요한 모든 정보를 가지고 있는 한 부분을 가리키는 말이다. 고전적인 생물학에서는 유전자가 표현형을 결정하거나 지정하는 염색체의 일부분이라고 정의되었지만, 오늘날에는 유전자에 대해서 분자적 정의가 제안되고 있으며 그 정의는 하나의 유전자는 하나의 효소를 결정 또는 암호화하는 유전물질의 일부분이라는 개념으로 이것이 이른바 1개의 유전자 1개 효소가설(one gene-one enzyme hypothesis)이다. 즉 1개의 유전자는 1개의 효소를 제작하는데 필요한 유전정보를 가진다는 것이다. 현재 이 가설이 받아들여지고 있다. |
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| 영문 | gene therapy | 한글 | 유전자요법 |
|---|---|---|---|
| 설명 | 유전병을 치료할 목적으로, 정상적으로 기능하는 단일유전자 혹은 복수유전자를 어떤 기원에서 얻어내어 생세포에 도입하는 것. 유전물질은 유전자삽입 조작에 의해 수용세포에로 도입된다. 즉, 유전자를 끼워 넣은 새로운 세포를 사용하는 치료로서 1980년 미국의 학자가 지중해빈혈환자에게 강행하여 비판을 받았지만, 미국 국립보건연구소는 1990년 9월 아데노신 데아미나아제(adenosine deaminase, ADA) 결핍증 환자의 림프구에 ADA 유전자를 끼워 넣는 치료를 시작한 이래 현재는 암을 포함한 많은 질병들을 치료하는 목적으로 쓰인다. |
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| recon | the smallest unit of DNA capable of recombination [recombination + Gr. on quantum] |
|---|---|
| RAG | ragweed; recombination activating gene |
| HFR | high-frequency recombination |
| REC | receptor; recombination, recombinant [chromosome] |
| RECA | recombination protein A |
| RAG-1 | Recombination Activating Gene-1 |
|---|---|
| RAG | Recombination activating gene |
| RAG-2 | Recombination-activating gene-2 |
| HR | Homologous recombination |
| RN | recombination nodule |
| genetic recombination | <molecular biology> Formation of new combinations of alleles in offspring (viruses, cells or organisms) as a result of exchange of DNA sequences between molecules. It occurs naturally, as in crossing over between homologous chromosomes in meiosis or experimentally, as a result of genetic engineering techniques. (18 Nov 1997) |
|---|---|
| recombination | <molecular biology> The creation, by a process of intermolecular exchange, of chromosomes combining genetic information from different sources, typically two genomes of a given species. Site specific, homologous, transpositional and nonhomologous illegitimate) types of recombination are known. 1st ed (18 Nov 1997) |
| recombination coefficient | <radiobiology> The rate of recombination of positive ions with electrons (or negative ions) in a gas, per unit volume, divided by the product of the particle densities of the two species (positive ions and electrons/negative ions) involved. (09 Oct 1997) |
| recombination fraction | The proportion of progeny of a mating pair of specific genotype and coupling phase that are recombinant; there must be no differential selection among the possible types of progeny, and the recombination fraction should be the same regardless of the alleles involved or their coupling phase. (05 Mar 2000) |
| recombination frequency | The frequency at which crossingover occurs between two chromosomal loci--the probability that twoloci will become unlinked during meiosis. (09 Oct 1997) |
| recombination, genetic | Production of new arrangements of genes by various mechanisms such as assortment and segregation, crossing over, gene conversion, transformation, conjugation, transduction, f-duction, or mixed infection of viruses. (12 Dec 1998) |
| recombination nodule | <molecular biology> Protein containing assemblies of about 90 nm diameter placed at intervals in the synaptonemal complexes that develop between homologous chromosomes at the zygotene stage of meiosis. Some nodules may be associated with the site of recombination. (18 Nov 1997) |
| recombination radiation | <physics> Radiation produced when a free electron in a plasma is captured by an ion. (09 Oct 1997) |
| mitotic recombination | <genetics, molecular biology> Somatic crossing over. Crossing over can occur between homologous chromosomes during mitosis, but is very rare because the chromosomes do not normally pair. When it occurs it can lead to new combinations of previously linked genes. Although infrequent, mitotic recombination has been utilised for genetic analysis in Aspergillus and in studies on developmental compartments in Drosophila where the frequency of mitotic recombination can be increased by X irradiation. (18 Nov 1997) |
| high frequency recombination strain | A type of bacterial strain which is able to pass on genetic information to neighboring bacteria at a high rate. The high-frequency recombination strain (Hfr) is able to do this because it possesses the f plasmid and can therefore initiate bacterial conjugation. (09 Oct 1997) |
| homologous recombination | <molecular biology> Genetic recombination involving exchange of homologous loci. Important technique in the generation of null alleles (knockouts) in transgenic mice. (18 Nov 1997) |
| site-specific recombination | <molecular biology> A type of recombination that occurs between two specific short DNA sequences present in the same or in different molecules. An example is the integration and excision of _ prophage. (18 Nov 1997) |
| somatic recombination | One of the mechanisms used to generate diversity in antibody production is to rearrange the DNA in B-cells during their differentiation, a process that involves cutting and splicing the immunoglobulin genes. Somatic recombination via homologous crossing over occurs at a low frequency in Aspergillus, Drosphilia and Saccharomyces and in mammalian cells in culture. It may be detected through the production of homozygous patches or sectors after mitosis of cells heterozygous for suitable marker genes. (18 Nov 1997) |
| dissociative recombination | <radiobiology> The combination of an electron with a positive molecular ion, followed by dissociation of the molecule in which the resulting atoms/molecules carry off the excess energy released in the recombination. (09 Oct 1997) |
| allelic gene | See: allele, dominance of traits. (05 Mar 2000) |
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|