| 영문 | gene | 한글 | 유전자 |
|---|---|---|---|
| 설명 | 유전자는 길게 띠를 형성한 DNA분자의 일부분으로 한 가지 물질을 만드는데 필요한 모든 정보를 갖춘 기능적인 단위이다. 예를 들어 인슐린이라는 물질의 유전자라고 하면 사람의 세포내에 있는 긴 DNA 분자 중에서 인슐린이라는 물질을 만드는데 필요한 모든 정보를 가지고 있는 한 부분을 가리키는 말이다. 고전적인 생물학에서는 유전자가 표현형을 결정하거나 지정하는 염색체의 일부분이라고 정의되었지만, 오늘날에는 유전자에 대해서 분자적 정의가 제안되고 있으며 그 정의는 하나의 유전자는 하나의 효소를 결정 또는 암호화하는 유전물질의 일부분이라는 개념으로 이것이 이른바 1개의 유전자 1개 효소가설(one gene-one enzyme hypothesis)이다. 즉 1개의 유전자는 1개의 효소를 제작하는데 필요한 유전정보를 가진다는 것이다. 현재 이 가설이 받아들여지고 있다. |
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| 영문 | gene therapy | 한글 | 유전자요법 |
|---|---|---|---|
| 설명 | 유전병을 치료할 목적으로, 정상적으로 기능하는 단일유전자 혹은 복수유전자를 어떤 기원에서 얻어내어 생세포에 도입하는 것. 유전물질은 유전자삽입 조작에 의해 수용세포에로 도입된다. 즉, 유전자를 끼워 넣은 새로운 세포를 사용하는 치료로서 1980년 미국의 학자가 지중해빈혈환자에게 강행하여 비판을 받았지만, 미국 국립보건연구소는 1990년 9월 아데노신 데아미나아제(adenosine deaminase, ADA) 결핍증 환자의 림프구에 ADA 유전자를 끼워 넣는 치료를 시작한 이래 현재는 암을 포함한 많은 질병들을 치료하는 목적으로 쓰인다. |
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| IVET | in vivo expression technology |
|---|---|
| NGBE | neuraminidase/beta-galactosidase expression |
| FAR | Federal acquisitions regulation; fractional albumin rate; fresh bone marrow |
| FR | failure rate; film-screen radiograph; fasciculus retroflexus; febrile reaction; feedback regulation;... |
| IRIS | integrated risk information system; interleukin regulation of immune system; International Research ... |
| ESAG | expression site-associated gene |
|---|---|
| SAGE | Serial Analysis of Gene Expression |
| BEVS | Baculovirus Expression Vector System |
| IVET | In vivo expression technology |
| STAXI | State Trait Anger Expression Inventory |
| gene expression regulation | Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action at the level of transcription or translation. These processes include gene activation and genetic induction. (12 Dec 1998) |
|---|---|
| gene expression regulation, archaeal | Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in archaea. (12 Dec 1998) |
| gene expression regulation, bacterial | Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria. (12 Dec 1998) |
| gene expression regulation, developmental | Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. (12 Dec 1998) |
| gene expression regulation, enzymologic | Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis. (12 Dec 1998) |
| gene expression regulation, fungal | Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi. (12 Dec 1998) |
| gene expression regulation, leukaemic | Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in leukaemia. (12 Dec 1998) |
| gene expression regulation, neoplastic | Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue. (12 Dec 1998) |
| gene expression regulation, plant | Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants. (12 Dec 1998) |
| gene expression regulation, viral | Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses. (12 Dec 1998) |
| gene regulation | The DNA and protein interactions in a gene that determine the temporal and spatial modes of expression as well as the amplitude of expression. (14 Nov 1997) |
|---|---|
| gene expression | <molecular biology> The full use of the information in a gene via transcription and translation leading to production of a protein and hence the appearance of the phenotype determined by that gene. Gene expression is assumed to be controlled at various points in the sequence leading to protein synthesis and this control is thought to be the major determinant of cellular differentiation in eukaryotes. (18 Nov 1997) |
| differential gene expression | Gene expression that responds to signals or triggers; a means of gene regulation; e.g., effects of certain hormones on protein biosynthesis. (05 Mar 2000) |
| expression, gene | A gene speaks. When a gene is expressed, the information encoded in the gene is translated into protein or RNA structures present and operating in the cell. Expressed genes include genes that are transcribed into messenger RNA (mRNA) and then translated into protein as well as those genes that are transcribed into RNA (such transfer and ribosomal RNAs) but not translated into protein. (12 Dec 1998) |
| appetite regulation | Physiologic mechanisms which regulate or control the appetite and food intake. (12 Dec 1998) |
| regulation | 1. <biology> The adaption of form or behaviour of an organism to changed conditions. 2. <embryology> The power of a pregastrula stage to form a whole embryo from a part. Origin: L. Regula = rule (18 Nov 1997) |
| coordinate regulation | The expression of many different genes at once. (09 Oct 1997) |
| self-regulation | A three-stage strategy patients are taught to use in order to end risky health-associated behaviours such as smoking and overeating. 1. Self-monitoring (self-observation), the first stage in self-regulation involves the individual's deliberately attending to and recording his or her own behaviour; 2. Self-evaluation, the second stage, in which the individual assesses what was learned by self-monitoring, such as how often and where one smokes, and uses those observational data to establish health goals or criteria; 3. Self-reinforcement, the third stage, in which the individual rewards him/herself for each behavioural success on the road to that goal, thereby enhancing the chance of reaching it. (05 Mar 2000) |
| negative regulation | Negative feedback in biological systems mediated by allosteric regulatory enzymes. (18 Nov 1997) |
| down-regulation | <physiology> Development of a refractory or tolerant state consequent upon repeated administration of a pharmacologically or physiologically active substance. It is the process that decreases ligand and receptor interactions or reduces the responsiveness of a cell to a stimulus following first exposure. This is often accompanied by an initial decrease in affinity of receptors for the agent and a subsequent reduction in the number of available receptors expressed on the surface which can result from internalisation of the ligand:receptor complex or from decreased expression of the receptor. Classically the concept referred to hormone receptors but contemporary usage includes other cell surface receptors. (03 Jul 1999) |
| target regulation | <physiology> General term for an interaction between neurons and their targets by which target derived signals influence the differentiation of the innervating neurons. (18 Nov 1997) |
| enzyme regulation | <biochemistry> Control of the rate of a reaction catalyzed by an enzyme by some effector (e.g., inhibitors or activators) or by alteration of some condition (e.g., pH or ionic strength). (05 Mar 2000) |
| facility regulation and control | Formal voluntary or governmental procedures and standards required of hospitals and health or other facilities to improve operating efficiency, and for the protection of the consumer. (12 Dec 1998) |
| feedback regulation | <physiology> Control mechanism that uses the consequences of a process to regulate the rate at which the process occurs: if, for example: the products of a reaction inhibit the reaction from proceeding (or slow down the rate of the reaction), then there is negative feedback, something that is very common in metabolic pathways. Positive feedback is liable to lead to exponential increase and may be explosively dangerous in some cases. Other examples are the action of voltage dependent sodium channels in generating action potentials and the activation of blood clotting factors V and VIII by thrombin. Without damping, feedback can lead to resonance (hunting) and oscillation in the system. (18 Nov 1997) |
| up-regulation | Opposite of down-regulation. (05 Mar 2000) |
Synonyms : Expression Regulation, Gene, Induction, Genetic, Regulation, Gene Action, Regulation, Gene Expression, Activation, Gene
Synonyms : Regulation, Gene Expression, Archaeal
Synonyms : Regulation, Gene Expression, Bacterial
Synonyms : Regulation, Gene Expression, Developmental, Regulation, Gene Expression, Embryologic
Synonyms : Regulation, Gene Expression, Enzymologic
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|