| FAP | familial adenomatous polyposis; familial amyloid polyneuropathy; fatty acid polyunsaturated; fatty a... |
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| EPS | ear-patella-short stature [syndrome]; elastosis perforans serpiginosa; electrophysiologic study; enz... |
| APP | acute phase protein; alum-precipitated pyridine; aminopyrazolopyrimidine; amyloid peptide precursor;... |
| FAC | Familial Amyloid Cardiomyopathy |
| FAP | Familial Amyloid Polyneuropathy |
| EPS | Elastosis perforans serpiginosa |
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| FAP | Familial Amyloid Polyneuropathy |
| A beta | AD beta-amyloid |
| AA | Amyloid A |
| AA | Amyloid A protein |
| familial amyloid neuropathy | <neurology> A disorder in which various peripheral nerves are infiltrated with amyloid and their functions disturbed, an abnormal prealbumin is also formed and is present in the blood; characteristically, it begins during mid-life and is found largely in persons of Portuguese descent. Other rare clinical types occur. Inheritance: autosomal dominant. Synonym: familial amyloidosis, hereditary amyloidosis. (05 Mar 2000) |
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| solar elastosis | Elastosis seen histologically in the sun-exposed skin of the elderly or in those who have chronic actinic damage. (05 Mar 2000) |
| elastosis | 1. Degenerative change in elastic tissue. 2. Degeneration of collagen fibres, with altered staining properties resembling elastic tissue, or formation by fibroblast-activated ultraviolet or mast cell mediators of abnormal fibres. Synonym: elastoid degeneration, elastotic degeneration. (05 Mar 2000) |
| elastosis colloidalis conglomerata | Yellow papules developing in sun-damaged skin of the head and backs of the hands, composed of colloid material in the dermis resembling amyloid but with a different ultrastructure. Synonym: colloid acne, colloid pseudomilium, elastosis colloidalis conglomerata. Origin: L. Milium, millet (05 Mar 2000) |
| elastosis dystrophica | Tiny breaks in the elastin-filled tissue in the back of the eye (retinae). These abnormalities are visible to the doctor during an examination using a viewing instrument called an ophthalmoscope. Angioid streaks are seen in patients with pseudoxanthoma elasticum (abbreviated PXE), a rare disorder of degeneration of the elastic fibres with tiny areas of calcification in the skin, back of the eyes (retinae), and blood vessels. Angioid streaks can be associated with blindness. (12 Dec 1998) |
| elastosis perforans serpiginosa | Circinate groups of asymptomatic keratotic papules; the epidermis is thickened around a central plug of dermal elastic tissue which is extruded through the epidermis. (05 Mar 2000) |
| amyloid | Glycoprotein deposited extracellularly in tissues in amyloidosis. The glycoprotein may either derive from light chain of immunoglobulin (AIO (amyloid of immune origin): 5-18 kD glycoprotein, product of a single clone of plasma cells, the N terminal part of lambda or kappa light chain) or, in what used to be referred to as AUO, amyloid of unknown origin, from serum amyloid A (SAA), one of the acute phase proteins that increases many fold in inflammation. The polypeptides are organised as a _ pleated sheet making the material rather inert and insoluble. Minor protein components are also found. Should be distinguished from _ amyloid deposited in the brain and that is derived from amyloid precursor protein (see amyloidogenic glycoprotein. (18 Nov 1997) |
| amyloid A-degrading serine protease | <enzyme> Reduced in amyloidosis associated with rheumatoid arthritis Registry number: EC 3.4.21.- Synonym: amyloid a-degrading activity, aad-protease (26 Jun 1999) |
| amyloid angiopathy | Deposition of acellular hyaline material in small arteries and arterioles of the leptomeninges and cerebral cortex in the elderly with resulting predilection for recurrent lobar intraparenchymal haematomas. (05 Mar 2000) |
| amyloid beta-protein | A 4 kD protein, 39-43 amino acids long, expressed by a gene located on chromosome 21. It is the major protein subunit of the vascular and plaque amyloid filaments in individuals with alzheimer's disease and in aged individuals with trisomy 21 (down syndrome). The protein is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue. (12 Dec 1998) |
| amyloid beta-protein precursor | A precursor to the amyloid-beta protein (beta/a4). Alterations in the expression of the amyloid beta-protein precursor (abpp) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both alzheimer disease and down syndrome. Abpp is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/a4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in alzheimer disease, down syndrome and, to a limited extent, in normal aging. (12 Dec 1998) |
| amyloid bodies of the prostate | An obsolete term for small masses of colloid material often present in the tubules of the gland. See: corpus amylaceum. (05 Mar 2000) |
| amyloid corpuscle | One of a number of small ovoid or rounded, sometimes laminated, bodies resembling a grain of starch and found in nervous tissue, in the prostate, and in pulmonary alveoli; of little pathological significance, and apparently derived from degenerated cells or proteinaceous secretions. Synonym: amniotic corpuscle, amylaceous corpuscle, amyloid corpuscle, colloid corpuscle. (05 Mar 2000) |
| amyloid degeneration | Infiltration of amyloid between cells and fibres of tissues and organs. Synonym: waxy degeneration. (05 Mar 2000) |
| amyloid kidney | A kidney in which amyloidosis has occurred, usually in association with some chronic illness such as multiple myeloma, tuberculosis, osteomyelitis, or other chronic suppurative inflammation; such kidney's are moderately enlarged and grossly manifest a waxy appearance, with amyloid deposited beneath the endothelium in the glomerular loops and in the arterioles, apparently beginning as foci of thickening of the basement membranes. Synonym: waxy kidney. (05 Mar 2000) |
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