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establish 1. To make stable or firm; to fix immovably or firmly; to set (a thing) in a place and make it stable there; to settle; to confirm. "So were the churches established in the faith." (Acts xvi. 5) "The best established tempers can scarcely forbear being borne down." (Burke) "Confidence which must precede union could be established only by consummate prudence and self-control." (Bancroft)
2. To appoint or constitute for permanence, as officers, laws, regulations, etc.; to enact; to ordain. "By the consent of all, we were established The people's magistrates." (Shak) "Now, O king, establish the decree, and sign the writing, that it be not changed." (Dan. Vi. 8)
3. To originate and secure the permanent existence of; to found; to institute; to create and regulate; said of a colony, a state, or other institutions. "He hath established it [the earth], he created it not in vain, he formed it to be inhabited." (Is. Xlv. 18) "Woe to him that buildeth a town with blood, and establisheth a city by iniquity!" (Hab. Ii. 12)
4. To secure public recognition in favor of; to prove and cause to be accepted as true; as, to establish a fact, usage, principle, opinion, doctrine, etc. "At the mouth of two witnesses, or at the mouth of three witnesses, shall the matter be established." (Deut. Xix. 15)
5. To set up in business; to place advantageously in a fixed condition; used reflexively; as, he established himself in a place; the enemy established themselves in the citadel.
Origin: OE. Establissen, OF. Establir, F. Etablir, fr. L. Stabilire, fr. Stabilis firm, steady, stable. See Stable, -ish, and cf. Stablish.
Source: Websters Dictionary
(01 Mar 1998)
established cell line <cell culture> A cell line is a permanently established cell culture that will proliferate indefinitely given appropriate fresh medium and space.
Lines differ from cell strains in that they have escaped the Hayflick limit and become immortalised. Some species, particularly rodents, give rise to lines relatively easily, whereas other species do not. No cell lines have been produced from avian tissues and the establishment of cell lines from human tissue is difficult. Many cell biologists would consider that a cell line is by definition already abnormal and that it is on the way towards becoming the culture equivalent of a neoplastic cell.
(26 Mar 1998)
Establishment License Application <pharmacology> An application submitted concurrently with the Product License Application. The Establishment Licence Application provides data demonstrating the acceptability of the facilities and personnel for manufacturing of protein pharmaceuticals.
Acronym: ELA
(14 Nov 1997)
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established cell line Cultured cells that may be subcultured indefinitely.
Ãâó: www.genpromag.com/Glossary~LETTER~E.html
established cell l. see cell l.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
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establish use as a basis for
establish establish the validity of something, as by an example, explanation or experiment
establish institute, enact, or establish
establish place
establish set up or lay the groundwork for
establish bring about
establish build or establish something abstract
establish set up or found
establish introduced from another region and persisting without cultivation
establish brought about or set up or accepted
establish conforming with accepted standards
establish shown to be valid beyond a reasonable doubt
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