| EBI | emetine bismuth iodide; erythroblastic island; estradiol binding index |
|---|---|
| EBL | erythroblastic leukemia; estimated blood loss |
| is | in situ; island; islet; isolated |
| CIMP | CpG island methylator phenotype |
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| HPI | High-Pathogenicity Island |
| PAI | Pathogenicity Island |
| RIR | Rhode Island Red |
| SPI1 | Salmonella Pathogenicity Island 1 |
| primary erythroblastic anaemia | The dire disease also known as beta thalassaemia. The clinical picture of this form of anaemia was first described in 1925 by the paediatrician thomas benton cooley. Other names for the disease are cooley's anaemia and mediterranean anaemia. The term thalassaemia was coined by the nobel prise winning pathologist george whipple and the professor of paediatrics william bradford at u. Of rochester because thalassa in greek means the sea (like the mediterrranean sea) + -aemia means in the blood so thalassaemia means sea in the blood. Thalassaemia is not just one disease. It is a complex contingent of genetic (inherited) disorders all of which involve underproduction of haemoglobin, the indispensable molecule in red blood cells that carries oxygen. The globin part of normal adult haemoglobin is made up of 2 alpha and 2 beta polypeptide chains. In beta thalassaemia, there is a mutation (change) in both beta globin chains leading to underproduction (or absence) of beta chains, underproduction of haemoglobin, and profound anaemia. The gene for beta thalassaemia is relatively frequent in people of mediterranean origin (for example, from italy and greece). Children with this disease inherit one gene for it from each parent (and so are said to be homozygous for beta thalassaemia). The parents are carriers (heterozygotes) with just one thalassaemia gene, are said to have thalassaemia minor, and are essentially normal. Their children affected with beta thalassaemia seem entirely normal at birth (because at birth we still have predominantly foetal haemoglobin which does not contain beta chains) but the anaemia emerges in the first few months of life and becomes progressively more severe leading to pallor and easy fatiguability, failure to thrive (grow), bouts of fever (due to infections) and diarrhoea. Treatment based on blood transfusions is helpful but not curative. Gene therapy will, it is hoped, be applicable to this disease. (12 Dec 1998) |
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| erythroblastic anaemia | Anaemia characterised by the presence of large numbers of nucleated red cells (normoblasts and erythroblasts) in the peripheral blood. Seen especially in newborns with haemolytic anaemia, such as that caused by Rh or ABO incompatibility. Synonym: erythroblastic anaemia. (05 Mar 2000) |
| familial erythroblastic anaemia | An outmoded term for thalassaemia major. (05 Mar 2000) |
| leukaemia, erythroblastic, acute | A myeloproliferative disorder characterised by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood. (12 Dec 1998) |
| bam island | <molecular biology> Areas of DNA which do not get transcribed, consisting of many repeats of the same sequence of nucleotide bases. (13 Nov 1997) |
| blood island | An aggregation of splanchnic mesodermal cells on the embryonic yolk sac, with the potentiality of forming vascular endothelium and primitive blood cells. Synonym: blood islet. (05 Mar 2000) |
| bone island | <radiology> Small, intramedullary island of compact bone, usually negative on bone scan, shaggy, slightly stellate border, Differential diagnosis: osteoid osteoma, multiple leading to osteopoikilosis (12 Dec 1998) |
| magnetic island | <physics> A magnetic topology near a rational surface where the flux surface is broken up into tubes which are not connected with each other poloidally. Islands may develop in non-ideal magnetohydrodynamic fluids, where electrical resistance becomes important and magnetic field lines are no longer frozen-in to the fluid. Then magnetic tearing and reconnection may allow field lines to link up and form islands with a local magnetic axis in a narrow region near a rational surface. (See also magnetohydrodynamic, frozen-in law). The development of islands may be caused by a small perturbation, whether internal or external, whether deliberate or accidental, and is usually associated with enhanced transport (i.e., reduced confinement). The centres of the islands are magnetic O-points, while the boundaries between islands are marked by X-points. (09 Oct 1997) |
| pitcairn island | An island in polynesia, in the south pacific ocean. It was discovered in 1767 by philip carteret, uninhabited until 1790 when settled by mutineers from the english ship, bounty. The settlement was discovered in 1808; the population was removed temporarily to tahiti in 1831 and to norfolk island (between new caledonia and new zealand) in 1856. Some later returned to pitcairn and their descendents constitute the present population of this british colony. The island is named for the midshipman who first sighted it from the ship. (12 Dec 1998) |
| CpG island | <molecular biology> Region of genomic DNA rich in the dinucleotide C G. Methylation of the C in the dinucleotide is maintained through cell divisions and profoundly affects the degree of transcription of the nearby genes and is important in developmental regulation of gene expression. (18 Nov 1997) |
| cpg-rich island | <molecular biology> Areas of DNA which consist mostly of the base pair sequence CGCGCGCG. (alternating cytosine and guanine nucleotide bases) that are usually found upstream of many genes and are thought to help regulate gene expression. They are often methylated (have methyl groups attached to the DNA segments). (28 May 1998) |
| prince edward island | An island in the gulf of st. Lawrence constituting a province of canada in the eastern part of the country. It is very irregular in shape with many deep inlets. Its capital is charlottetown. Discovered by the french in 1534 and originally named ile saint-jean, it was renamed in 1799 in honor of prince edward, fourth son of george III and future father of queen victoria. (12 Dec 1998) |
| island | 1. <geography> A tract of land surrounded by water, and smaller than a continent. Cf. Continent. 2. Anything regarded as resembling an island; as, an island of ice. Origin: OE. Iland, yland, AS. Igland, gland, glond; ig, g, island + land, lond, land. AS. Ig, g, is akin to AS. Ea water, river, OHG. Uwa, G. Au meadow, Icel. Ey island, Dan. & Sw. O, Goth. Ahwa a stream, water, L. Aqua water. The s is due to confusion with isle. Cf. Ait, Eyot, Ewer, Aquatic. Source: Websters Dictionary (01 Mar 1998) |
| island disease | See Typhus, scrub. (12 Dec 1998) |
| island fever | See Typhus, scrub. (12 Dec 1998) |
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