| ¿µ¹® | drug resistance | ÇÑ±Û | ¾à¹°³»¼º |
|---|---|---|---|
| ¼³¸í | 1. ÈÇпä¹ýÁ¦³ª Ç×»ý¹°ÁúÀÇ ¾î¶² ÀÏÁ¤ ³óµµ·Î ¼¼±ÕÀ» Á×À̰ųª Áõ½ÄÀúÇØ¸¦ ¹Þ´Â °ÍÀ» ÀÌ ÈÇпä¹ýÁ¦³ª Ç×»ý¹°Áú¿¡ °¨¼ö¼ºÀÌ ÀÖ´Ù°í Çϴµ¥, ÀÌ °¨¼ö¼ºÀÌ ¾ø°Ô µÈ »ýŸ¦ ÀúÇ×¼ºÀ̶óµç°¡ ³»¼ºÀ̶ó°í ¸»ÇÑ´Ù. µû¶ó¼ º¯À̹̻ý¹°ÀÇ ¾àÁ¦¿¡ ´ëÇÑ ÀÚÇ×¼ºÀ̶óµç°¡ ³»¼ºÀ̶ó°í ¸»ÇÑ´Ù. 2. ÀǾàǰÀ» °è¼Ó º¹¿ëÇϸé Á¡Â÷ Áõ·®ÇÏÁö ¾ÊÀ¸¸é È¿·ÂÀÌ ³ªÅ¸³ªÁö ¾Ê´Â ¼ºÁú. ÀÌ·¯ÇÑ ¶§¸¦ ¾àÁ¦³»¼ºÀÌ »ý°å´Ù°í ÇÑ´Ù. ¸ðµç ¹Ì»ý¹°Àº °¨¼ö¼ºÀ» °¡Áö´Â ¾à¹°¿¡ ÀÇÇÏ¿© »ç¸êµÇÁö¸¸, ¼Ò¼öÀÇ °ÍÀº »ì¾Æ³²¾Æ ±×°ÍÀÌ ÁøÈµÊÀ¸·Î½á »ç¸êÇÏÁö ¾Ê´Â ¼ö°¡ ÀÖ´Ù. ¶Ç, ÃÖÃÊ¿¡´Â °¨¼ö¼ºÀ» °¡Áö°í ÀÖ´ø ±ÕÀÌ Â÷Â÷ ³»¼º±ÕÀ¸·Î µÇ±âµµ ÇÑ´Ù. ¸¹Àº º´¿ø±ÕÀº °¨¼ö¼ºÀÌ ÀÖ´Â ÀǾàǰ¿¡ ´ëÇÏ¿© ³»¼ºÀÌ »ý±ä´Ù. °¡Àå °íµµÀÇ ³»¼º±ÕÀÌ »ý±â±â ½¬¿î °ÍÀº ½ºÆ®·¾Å丶À̽ÅÀε¥ °áÇÙ±Õ°ú ±×¶÷À½¼º±Õ¿¡ ´ëÇÏ¿© ½±°Ô ³»¼ºÀÌ »ý±ä´Ù. Æä´Ï½Ç¸°À̳ª Åׯ®¶ó½ÃŬ¸°(¾ÆÅ©·Î¸¶À̽Å) µîÀÇ Ç×»ý¹°Áúµµ ³»¼ºÀÌ »ý±â±â ½¬¿ì¹Ç·Î, »ç¿ëÇÒ ¶§´Â ÀûÀÀÀ» Àß È®ÀÎÇÏ¿© Çʿ䷮À» Á¤ÇÏ°í ¿¬¿ëÀ» ÇÇÇÑ´Ù. °°Àº È¿°ú°¡ ÀÖ´Â ´Ù¸¥ Á¾·ùÀÇ ¾àÁ¦¸¦ ¼Ò·®¾¿ 2, 3Á¾ º´¿ëÇÏ¸é ³»¼ºÀÇ ¹ß»ýÀÌ Å©°Ô ¾ïÁ¦µÈ´Ù´Â °ÍÀÌ ¾Ë·ÁÁ® ÀÖ´Ù. °áÇÙ¾àÀ¸·Î¼ ½ºÆ®·¾Å丶À̽Űú ÆÄ½º, ¶Ç´Â À̼ҴϾÆÁöµå¸¦ º´¿ëÇÏ´Â °Í µîÀÌ ±× ¿¹ÀÌ´Ù. |
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| ¿µ¹® | plasmid | ÇÑ±Û | Çö󽺹̵å |
|---|---|---|---|
| ¼³¸í | ÇÙ ÀÌ¿ÜÀÇ ¼¼Æ÷Áú ¼Ó¿¡ ÀÖ´Â À¯ÀüÀÚ DNA. ÁÖ·Î »ç¸³Ã¼, »ö¼Òü µûÀ§ÀÇ ¼¼Æ÷ ¼Ò±â°ü¿¡¼ º¼ ¼ö ÀÖ´Â DNA¿Í Çö󽺹̵å DNA¸¦ ÅëÆ²¾î À̸¥´Ù. ¼¼±Õ¼¼Æ÷³»¿¡¼ ¹ß°ßµÇ´Â ¿°»öü ÀÌ¿ÜÀÇ ÀÚ°¡º¹Á¦ À¯ÀüÀÚ ±¸Á¶·Î¼, ¼¼Æ÷¼ºÀå¿¡ ÇʼöÀûÀÌ ¾Æ´Ñ ¿©·¯ °¡Áö ±â´ÉÀÇ À¯ÀüÀÚ¸¦ °¡Áö°í ÀÖ´Ù. Çö󽺹̵å´Â ¼÷ÁÖÀÇ »ýÁ¸¿¡ ÇʼöÀûÀÎ °ÍÀº ¾Æ´Ï¸ç, ¼¼±Õ¿°»öü¿Í ¾î´À Á¤µµ¸¦ °ü·ÃÀ» °¡Áö¸ç µ¶ÀÚÀûÀ¸·Î º¹Á¦Çϰí, ´Ù¾çÇÑ ÇüÁúÀ» ¼÷ÁÖ¿¡ ºÎ°¡ÇØ, µþ¼¼Æ÷¿¡ Àü´ÞÇÑ´Ù. ÇÃ¶ó½º¹Ìµå »ó¿¡´Â º¹Á¦¿¡ °üÇÑ À¯ÀüÀÚ ¿Ü¿¡, ¾àÁ¦ ³»¼ºÀÎÀÚ(RÀÎÀÚ), âÀÚ°ü µ¶¼Ò»ý¼º, ¼º°áÁ¤ÀÎÀÚ(FÀÎÀÚ) µîÀÇ À¯ÀüÀÚ¸¦ °®°í ÀÖ´Â °ÍÀÌ ÀÖ´Ù. Àü´Þ¼º Çö󽺹̵å´Â ´Ù¸¥ ±Õ°úÀÇ Á¢ÇÕÀ» À¯¹ß½ÃÄÑ ÀÚ½ÅÀÇ DNA¸¦ Àü´ÞÇÒ ¼ö ÀÖ´Ù. ±Ù·¡ Çö󽺹̵å´Â ±× Ư¼ºÀ» ÀÌ¿ëÇØ¼ À¯Àü°øÇп¡ ÀÌ¿ëµÉ °¡´É¼ºÀÌ ÀÖ¾î¼ Å©°Ô ÁÖ¸ñµÇ°í ÀÖ´Ù. ¼¼±Õ ³»ÀÇ Çö󽺹̵带 ¼¼Æ÷ ¹ÛÀ¸·Î »©³»°í Á¦ÇÑÈ¿¼Ò·Î °í¸®¸¦ ²÷Àº µÚ, °¡·É »ç¶÷ÀÇ Àν¶¸°À» ¸¸µå´Âµ¥ °ü¿©ÇÏ´Â DNA Á¶°¢À» ÀÌ¿¡ ³¢¿ö ¸ÂÃç ´Ù½Ã ¼¼±ÕÀÇ ¼¼Æ÷ ³»·Î µ¹·Áº¸³» ³Ö¾îÁÖ¸é ÀÌÁ¾ÀÇ DNA Á¶°¢À» °¡Áø ÀâÁ¾ Çö󽺹̵å´Â Á¤»óÀûÀ¸·Î Áõ½ÄÇÏ°í ¼¼±ÕÀÌ ºÐ¿ÇÒ ¶§¸¶´Ù Àν¶¸°À» »ý¼ºÇÏ°Ô µÈ´Ù. |
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| ¿µ¹® | resistance | ÇÑ±Û | ³»¼º, ÀúÇ×¼º |
|---|---|---|---|
| ¼³¸í | ¨ç ¾à¹°ÀÇ ¹Ýº¹ º¹¿ë¿¡ ÀÇÇØ ¾àÈ¿°¡ ÀúÇÏÇÏ´Â Çö»ó. ¨è ¼¼±Õ µûÀ§ÀÇ º´¿øÃ¼°¡ ÈÇÐ ¿ä¹ýÁ¦³ª Ç×»ý ¹°ÁúÀÇ °è¼Ó »ç¿ë¿¡ ´ëÇÏ¿© ³ªÅ¸³»´Â ÀúÇ×¼º. ¼¼±ÕÀÇ ³»¼ºÈ¹µæÀÇ ¸ÞÄ¿´ÏÁò¿¡ ´ëÇØ¼´Â ¼¼Æ÷ÀÇ ±¸Á¶(¸®Æ÷Á», ¼¼Æ÷¸·) º¯È, ´ë»ç°èÀÇ º¯È, µ¹¿¬º¯ÀÌ µî¿¡ ÀÇÇÑ ¾à¹°°¨¼ö¼º ÀúÇÏ µîÀÌ ÃßÃøµÇ°í ÀÖ´Ù. ÇÑÆí ´Ù¸¥ ¾à¹°¿¡µµ ³»¼ºÀ» ³ªÅ¸³»´Â ±³Â÷³»¼º°ú, ¿©·¯ Á¾·ùÀÇ ¾à¹°¿¡ µ¿½Ã¿¡ ³»¼ºÀ» ȹµæÇÑ »óŸ¦ ´ÙÁ¦ ³»¼ºÀ̶ó°í ÇÑ´Ù. 3. ȯ°æ Á¶°ÇÀÇ º¯È¿¡ °ßµô ¼ö ÀÖ´Â »ý¹°ÀÇ ¼ºÁú. ³»¿¼º, ³»ÇѼº µûÀ§°¡ ÀÖ´Ù. |
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| ¿µ¹® | resistance | ÇÑ±Û | ÀúÇ× |
|---|---|---|---|
| ¼³¸í | ¨ç¾à¹°ÀÇ ¹Ýº¹ º¹¿ë¿¡ ÀÇÇØ ¾àÈ¿°¡ ÀúÇÏÇÏ´Â Çö»ó. ¨è ¼¼±Õ µûÀ§ÀÇ º´¿øÃ¼°¡ ÈÇÐ ¿ä¹ýÁ¦³ª Ç×»ý ¹°ÁúÀÇ °è¼Ó »ç¿ë¿¡ ´ëÇÏ¿© ³ªÅ¸³»´Â ÀúÇ×¼º. ¼¼±ÕÀÇ ³»¼ºÈ¹µæÀÇ ¸ÞÄ¿´ÏÁò¿¡ ´ëÇØ¼´Â ¼¼Æ÷ÀÇ ±¸Á¶(¸®Æ÷Á», ¼¼Æ÷¸·) º¯È, ´ë»ç°èÀÇ º¯È, µ¹¿¬º¯ÀÌ µî¿¡ ÀÇÇÑ ¾à¹°°¨¼ö¼º ÀúÇÏ µîÀÌ ÃßÃøµÇ°í ÀÖ´Ù. ÇÑÆí ´Ù¸¥ ¾à¹°¿¡µµ ³»¼ºÀ» ³ªÅ¸³»´Â ±³Â÷³»¼º°ú, ¿©·¯ Á¾·ùÀÇ ¾à¹°¿¡ µ¿½Ã¿¡ ³»¼ºÀ» ȹµæÇÑ »óŸ¦ ´ÙÁ¦ ³»¼ºÀ̶ó°í ÇÑ´Ù. ¨é ȯ°æ Á¶°ÇÀÇ º¯È¿¡ °ßµô ¼ö ÀÖ´Â »ý¹°ÀÇ ¼ºÁú. ³»¿¼º, ³»ÇѼº µûÀ§°¡ ÀÖ´Ù. |
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| ¿µ¹® | antihypertensive drug | ÇÑ±Û | °íÇ÷¾Ð¾à, Ç×°íÇ÷¾ÐÁ¦ |
|---|---|---|---|
| ¼³¸í | °íÇ÷¾ÐÀÇ Ä¡·á¿¡ »ç¿ëÇÏ¸ç ³ôÀº Ç÷¾ÐÀ» ³·Ãß´Â ¾à¹°À» ¸»ÇÑ´Ù. °íÇ÷¾Ð¾à¿¡´Â Ç÷°üÆòȰ±Ù¿¡ Á÷Á¢ ÀÛ¿ëÇÏ¿© À̿ϽÃŰ´Â Ç÷°üÈ®ÀåÁ¦(È÷µå¶ó¶óÁø), ±³°¨½Å°æÀÇ È°µ¿À» ¾îµð¼±°¡ Â÷´ÜÇÏ´Â ¾à¹°(·¹¼¼¸£ÇÉ, ¸ÞÆ¿µµÆÄ, ÇÁ·ÎÇÁ¶ó³ë·Ñ), ÀÌ´¢Á¦(ÇÁ·Î¼¼¹Ìµå, ¿¡Å¸Å©¸°»ê)ÀÌ »ç¿ëµÈ´Ù. |
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| IR | drop of voltage across a resistor produced by a current; ileal resection; immune response; immunizat... |
|---|---|
| ER | efficiency ratio; epigastric region; ejection rate; electroresection; emergency room; endoplasmic re... |
| SR | sarcoplasmic reticulum; saturation recovery; scanning radiometer; screen; secretion rate; sedimentat... |
| DA | dark adaptation; dark agouti [rat]; daunomycin; degenerative arthritis; delayed action; Dental Assis... |
| F' | a hybrid F plasmid |
| Ipa | Invasion plasmid antigens |
|---|---|
| pDNA | Plasmid DNA |
| MDR | Multi drug resistance |
| MDR | Multiple Drug Resistance |
| MDR-1 | multi-drug resistance gene-1 |
| drug resistance | The ability of bacteria and other microorganisms to withstand a drug to which they were once sensitive (and were once stalled or killed outright). (12 Dec 1998) |
|---|---|
| drug resistance, microbial | The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through plasmids containing resistance factors (r factors). (12 Dec 1998) |
| drug resistance, multiple | Simultaneous resistance to a broad spectrum of structurally and functionally distinct drugs following exposure to a single agent. It is thought to result from the overexpression of genes encoding an integral plasma membrane protein, p-glycoprotein. (12 Dec 1998) |
| drug resistance, neoplasm | Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures. (12 Dec 1998) |
| drug-drug interaction | The effects that occur when two or more drugs are used together. Such effects include changes of absorption in the digestive tract, changes in rate of the drugs' breakdown in the liver, new or enhanced side effects and changes in the drugs' activity. (09 Oct 1997) |
| relaxed plasmid | A plasmid that replicatesindependently of the main bacterial chromosome and is present in 10-500 copies per cell. (09 Oct 1997) |
| RNA plasmid | <molecular biology> DsRNA found in yeasts, also called killer factors. Their nomenclature is uncertain and some scientists consider them viruses. (23 Aug 1998) |
| R plasmid | <molecular biology> A plasmid that confers resistance to one or more antibiotics or other poisonous compounds in a bacterium. (17 Dec 1997) |
| plasmid | <molecular biology> A small, independently replicating, piece of extrachromosomal cytoplasmic DNA that can be transferred from one organism to another. Linear or circular DNA molecules found in both pro and eukaryotes capable of autonomous replication. Stringent plasmids occur at low copy number in cells, relaxed plasmids at high copy number, ca 10 to 30. Plasmids can become incorporated into the genome of the host or can remain independent. An example is the f factor of E. Coli. May transfer genes and plasmids carrying antibiotic resistant genes can spread this trait rapidly through the population. Described largely from bacteria and protozoa. Some plasmids are capable of integrating into the host genome. A number of artificially constructed plasmids are used as cloning vectors. (14 Oct 1997) |
| conjugative plasmid | Self-transmissible plasmid, a plasmid which encodes all the functions needed for its own intercellular transmission by conjugation. (09 Oct 1997) |
| crown gall plasmid | A plasmid, or type of circular DNA, found in the bacteria Agrobacterium tumefaciens which infects dicot plants. Part of the plasmid inserts itself into the plant genome and causes tumours to form in the roots or in the stems nearest the roots. The plasmid has been used by geneticists, minus the tumour-causing parts, as a vector towards the genetic engineering of plants. (09 Oct 1997) |
| cryptic plasmid | A plasmid which has no apparent effect on the phenotype of its host cell and has no genes other than the ones needed for itself to replicate and spread to other cells. (09 Oct 1997) |
| hybrid plasmid | <molecular biology> A plasmid (circular DNA molecule) which is composed partly of the DNA of an organisms (or virus's) genome and partly of foreign DNA that has been inserted artificially. (09 Oct 1997) |
| stringent plasmid | <molecular biology> A plasmid that only replicates along with the main bacterial chromosome and is present as a single copy, or at most several copies, per cell. (16 Dec 1997) |
| nonconjugative plasmid | A plasmid that cannot effect conjugation and self-transfer to another bacterium (bacterial strain); transfer depends upon mediation of another (and conjugative) plasmid. (05 Mar 2000) |
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