| disintegrin | <protein> Peptides found in the venoms of various snakes of the viper family, that inhibit the function of some integrins of the _1 and _3 classes. They were first identified as inhibitors of platelet aggregation and were subsequently shown to bind with high affinity to integrins and to block the interaction of integrins with RGD containing proteins for example they block the binding of the platelet integrin _IIb_3 to fibrinogen. Disintegrins are effective inhibitors at molar concentrations 500-2000x lower than short RGDX peptides. They are cysteine rich peptides ranging from 45 to 84 amino acids in length and almost all of them have a conserved RGD sequence on a _ turn, presumed to be the site that binds to integrins. The assumption is that their biological role in the venom is to inhibit blood clotting. Found in many snake species, where they are called variously albolabrin, applagin, batroxostatin, bitistatin, echistatin, elegantin, flavouridin, halysin, kistrin, triflavin and trigramin. (18 Nov 1997) |
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| disintegrins | <chemical> A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (rgd) sequence. The rgd tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors. Pharmacological action: platelet aggregation inhibitors. (12 Dec 1998) |
Synonyms :
| disintegrin |
any of a family of proteins occurring in snake venoms and interrupting the function of integrins by blocking their interaction with surface receptors. In very low concentrations, disintegrins also inhibit platelet aggregation.
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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