| CMM | cell-mediated mutagenesis; cutaneous malignant melanoma |
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| MMM | see 3-M [syndrome]; microsome-mediated mutagenesis; myelofibrosis with myeloid metaplasia; myeloscle... |
| CDI | cell-directed inhibitor; central or chronic diabetes insipidus; Children's Depression Inventory; col... |
| DAD | delayed afterdepolarization; diffuse alveolar damage; dispense as directed |
| DSUH | directed suggestion under hypnosis |
| SDM | Site-directed mutagenesis |
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| STM | Signature-tagged mutagenesis |
| ADEPT | Antibody Directed Enzyme Prodrug Therapy |
| GDEPT | Gene directed enzyme prodrug therapy |
| PDPK | Proline-directed protein kinase |
| mutagenesis, site-directed | Mutagenesis where the mutation is caused by in vitro induction directed at a specific site in a DNA molecule. The most common method involves use of a chemically synthesised oligonucleotide mutant which can hybridise with the DNA target molecule. The resulting mismatch-carrying DNA duplex may then be transfected into a bacterial cell line and the mutant strands recovered. (12 Dec 1998) |
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| site-directed mutagenesis | <molecular biology> Any of several methods used to create specific alterations in a gene. (09 Oct 1997) |
| Antibody Directed Enzyme Prodrug Therapy | <pharmacology> A method for targeting a drug to a specific tissue, in which the targeting agent and the drug are administered separately. The drug is designed to be inactive (a prodrug) until it is converted by an enzyme, which is the targeting agent. The enzyme is coupled to an antibody that directs it to the tissue of interest. When the enzyme arrives at the tissue, the prodrug is activated only at that site, sparing other tissues from potentially toxic side effects. Acronym: ADEPT (14 Nov 1997) |
| cassette mutagenesis | The production of mutants within a region (often bounded by unique restriction sites) by the use of synthetic oligonucleotides that fill the gap with mutants designed into the synthetic genetic material. (05 Mar 2000) |
| RNA-directed DNA polymerase | <enzyme> An enzyme that synthesises DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. Chemical name: Deoxynucleotide-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) Registry number: EC 2.7.7.49 (12 Dec 1998) |
| mutagenesis | The development of mutations. (09 Oct 1997) |
| mutagenesis, insertional | Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA can be inserted into or adjacent to a cellular proto-oncogene. Insertion of the provirus can cause mutations by interrupting coding sequences or regulatory elements, or cause unregulated expression of the proto-oncogene resulting in tumour formation. (12 Dec 1998) |
| site-specific mutagenesis | <cell culture, molecular biology> An in vitro technique in which an alteration is made at a specific site in a DNA molecule, which is then reintroduced into a cell. Various techniques are used, for the cell biologist, a very powerful approach to determining which parts of a protein or nucleotide sequence are critical to function. (18 Nov 1997) |
| directed molecular evolution | Techniques used to produce molecules exhibiting properties that conform to the demands of the experimenter. (12 Dec 1998) |
| DNA-directed DNA polymerase | <enzyme> DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair. Chemical name: Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) Registry number: EC 2.7.7.7 (12 Dec 1998) |
| DNA-directed RNA polymerase | <enzyme> A group of enzymes that catalyses DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesised. Chemical name: Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) Registry number: EC 2.7.7.6 (12 Dec 1998) |
| insertional mutagenesis | Generally, mutagenesis of DNA by the insertion of one or more bases. Specific examples: 1. Oncogenesis by insertion of a retrovirus adjacent to a cellular proto-oncogene. 2. A strategy of mutagenesis with transposons. After a round of transposition, progeny are screened by PCR, with transposon and gene specific primers, for the proximity of the transposon sequence to the gene of interest. As PCR can only produce products up to 1-2 kb, a large fraction of progeny identified as positive by PCR will have a transposon close enough to the gene to inactivate or otherwise alter its pattern of expression. (18 Nov 1997) |
| other-directed | Pertaining to a person readily influenced by the attitudes of others. (05 Mar 2000) |
| transposon mutagenesis | <molecular biology> Insertion of a transposon into a gene, this inactivates the host gene leading to a mutant phenotype and also confers the phenotype associated with the transposon gene. (09 Oct 1997) |
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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