| cytotropic | Having an affinity for cells. Synonym: cytophilic. (05 Mar 2000) |
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| cytotropic antibody | Antibody that has an affinity for certain kinds of cells, in addition to and unrelated to its specific affinity for the antigen that induced it, because of the properties of the Fc portion of the heavy chain. See: heterocytotropic antibody, homocytotropic antibody, cytotropic antibody test. Synonym: anaphylactic antibody, cytophilic antibody. (05 Mar 2000) |
| cytotropic antibody test | A rosette test for macrophage cytotropic antibody: monolayers of macrophages are exposed first to antibody cytotropic for macrophages, then to the antigen (for which the antibody is specific), and indicator sheep erythrocytes; if the antibody is specific for sheep erythrocytes, the latter will form a rosette around the macrophages directly, but if not, and the antigen is soluble, the antigen must be coupled to the sheep erythrocytes by an agent such as bis-diazotised benzidine. (05 Mar 2000) |
| cytotropic |
attracting cells; possessing an affinity for cells; said especially of antibodies that attach to cell surfaces. See also under antibody.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
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| cytotropic a. |
antibody that binds to mast cells and basophils at specific receptors; subsequent binding of antigen to the cell-fixed antibody triggers release of mediators of immediate hypersensitivity. Such antibodies produced by the animal itself in response to antigenic challenge or transferred from another animal of the same species (homocytotropic or reaginic antibodies or reagin) are always of the IgE class. In some cases IgG, IgA, or IgM from one species (heterocytotropic antibodies) can sensitize tissues of another species; e.g., rabbit IgG can sensitize guinea pig skin for passive cutaneous anaphylaxis.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
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