| COS | cheiro-oral syndrome; chief of staff; Clinical Orthopaedic Society; clinically observed seizures |
|---|---|
| FS | factor of safety; Fanconi syndrome; Felty syndrome; fibromyalgia syndrome; field stimulation; Fisher... |
| GnRH | Gonadotropin Releasing Hormone [HP 1898, 2034] = LHRH = Go... |
| CMS | children's medical services; Christian Medical Society; chronic myelodysplastic syndrome; chromosome... |
| DABP | D site albumin promoter binding protein |
| cos | cohesive end site |
|---|---|
| Site 1 | site |
| COS | Carbonyl sulfide |
| COS | Childhood-onset schizophrenia |
| cos | cohesive end |
| cos site | <molecular biology> A 12-nucleotide bases-long segment of single stranded DNA that exists at both ends of the bacteriophage lambda's double-stranded genome. The two cos sites at the ends of the genome are complementary to one another so that the genome can become circular once the virus has infected a host bacterium. The circular genome can then be duplicated continuously until there are many repeats of it strung together, the cos sites show the virus where to cut them apart right before they are packaged into individual capsids as new progeny viruses ready to infect more host cells. (10 Nov 1998) |
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| COS cell | <cell culture> A cell line derived from the african green monkey and used for transfection and cloning. The cells are simian fibroblasts (CV 1 cells) transformed by SV40 that is deficient in the origin of replication region. They express large T antigen constitutively and if transfected with a vector containing a normal SV40 origin have all the other early viral genes necessary to generate multiple copies of the vector and thus to give very high levels of expression. (04 Jul 1999) |
|---|---|
| Hippocrates of Cos | Greek physician, called the "Father of Medicine," circa 460-377 B.C. See: hippocratic facies, hippocratic fingers, hippocratic nails, school, succussion. (05 Mar 2000) |
| acceptor site | The ribosomal binding site for the aminoacyl-tRNA during protein synthesis. (05 Mar 2000) |
| acceptor splicing site | Boundary between the right end of an intron and the left end of the adjacent exon. Synonym: acceptor splicing site. (05 Mar 2000) |
| active site | <chemistry> A specific region of an enzyme where a substrate binds and catalysis takes place (binding site). (06 May 1997) |
| allosteric site | A specific site on a multi-subunit enzyme or other protein that is not the substrate binding site, but that when reversibly bound by an effector, induces a conformational change in the protein, altering its catalytic or binding properties. (12 Dec 1998) |
| amidation site | <molecular biology> A C terminus consensus sequence, required for C terminus amidation of peptides. Consensus is glycine, followed by 2 basic amino acids (arg or lys). (18 Nov 1997) |
| antibody combining site | <immunology> In immune network theory, an idiotope, an antigenic site of an antibody that is responsible for that antibody binding to an antigenic determinant (epitope). Also used of the site on a ligand molecule to which a cell surface receptor binds. (18 Nov 1997) |
| antigen-binding site | <immunology> In immune network theory, an idiotope, an antigenic site of an antibody that is responsible for that antibody binding to an antigenic determinant (epitope). Also used of the site on a ligand molecule to which a cell surface receptor binds. (18 Nov 1997) |
| antigen-combining site | See: paratope. (05 Mar 2000) |
| apurinic site | <molecular biology> Sites in DNA from which purines have been lost by cleavage of the deoxy ribose N glycosidic linkage. (18 Nov 1997) |
| apyrimidinic site | <molecular biology> A site on DNA where a base is missing, in this case a pyrimidine (either cytosine or thymine), but the phosphodiester backbone is still intact. Compare: apurinic site. (09 Oct 1997) |
| ATT site | <molecular biology> A site on the chromosome of the bacteria E. Coli where the lambda bacteriophage can insert its genome (all of its DNA) so that it can lie dormant and have its DNA reproduced whenever the bacterium reproduces for as long as the bacterium remains healthy (that is, so that it becomes lysogenic). (09 Oct 1997) |
| gaylus-site | <chemical> A yellowish white, translucent mineral, consisting of the carbonates of lime and soda, with water. Origin: Named after Gay-Lussac, the French chemist. (20 Mar 1998) |
| receptor site | Point of attachment of viruses, hormones, or other activators to cell membranes. (05 Mar 2000) |
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