| PHLOP | polymerase-halt-mediated linkage of primers |
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| CCEHRP | Committee to Coordinate Environmental Health and Related Programs |
| OCC | object-centered coordinate [method]; oral cholecystography |
| DLS | Dimer Linkage Structure |
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| LD | Linkage Disequilibrium |
| LG | Linkage Group |
| NPL | Non-parametric linkage |
| ORLS | Oxford Record Linkage Study |
| coordinate | 1. Any of the scales or magnitudes that serve to define the position of a point. 2. To perform the act of coordination. Origin: see coordination (05 Mar 2000) |
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| coordinate convulsion | A clonic convulsion in which the movements are seemingly purposeful, being exaggerations of those that may occur naturally. (05 Mar 2000) |
| coordinate covalent bond | A bond in which the two electrons shared by a pair of atoms belonged originally to only one of the atoms; often represented by a small arrow pointing toward the electron receiver; e.g., nitric acid, O(OH)N→O; phosphoric acid, (OH)3P→O. Synonym: coordinate covalent bond. (05 Mar 2000) |
| coordinate regulation | The expression of many different genes at once. (09 Oct 1997) |
| amide linkage | <biochemistry> This is a carboxylic acid containing an amino group (-NH2). In an alpha amino acid, the amino group is attached to the carbon atom directly beside the carboxyl group. (09 Oct 1997) |
| map, linkage | A map of the genes on a chromosome based on linkage analysis. A linkage map does not show the physical distances between genes but rather their relative positions, as determined by how often two gene loci are inherited together. The closer two genes are (the more tightly they are linked), the more often they will be inherited together. Linkage distance is measured in centimorgans (cm). (12 Dec 1998) |
| genetic linkage | <genetics> The term refers to the fact that certain genes tend to be inherited together, because they are on the same chromosome. Thus parental combinations of characters are found more frequently in offspring than nonparental. Linkage is measured by the percentage recombination between loci, unlinked genes showing 50% recombination. See: linkage equilibrium, linkage disequilibrium. (18 Nov 1997) |
| glucosidic linkage | <biochemistry> The linkages between dextrose molecules in a glucoside compound which must be hydrolysed (broken apart) to produce the dextrose molecules. (09 Oct 1997) |
| medical record linkage | The creation and maintenance of medical and vital records in multiple institutions in a manner that will facilitate the combined use of the records of identified individuals. (12 Dec 1998) |
| phosphodiester linkage | <biochemistry> A chemical linkage in which two alcohols are esterically boundto a bridging molecule of phosphoric acid. (31 Dec 1997) |
| Y-linkage | The state of a genetic factor (gene) being borne on the Y chromosome. This idea is analogous with X-linkage but since the Y chromosome does not fully take part in chiasma formation and recombination, it not amenable to analysis by conventional linkage methods. Little is known about its content. There is a gene for the H-Y antigen, and indirect arguments suggest that there is a principle that determines the formation of the testis and masculinization of the foetus but its localization, though narrowing the limits, remains elusive. (05 Mar 2000) |
| linkage | <genetics> Tendency for two or more non-allelic genes to be inherited together, because they are located more or less closely on the same chromosome. Thus parental combinations of characters are found more frequently in offspring than nonparental. Linkage is measured by the percentage recombination between loci. (04 Jul 1999) |
| linkage analysis | <genetics> Study aimed at establishing linkage between genes. Today linkage analysis serves as a way of gene-hunting and genetic testing. (12 Dec 1998) |
| linkage disequilibrium | <genetics> The occurrence of some genes together, more often than would be expected. Thus, in the HLA system of histocompatibility antigens, HLA A1 is commonly associated with B8 and DR3 and A2 with B7 and DR2, presumably because the combination confers some selective advantage. (18 Nov 1997) |
| linkage equilibrium | <genetics> Situation that should exist in a population undisturbed by selection, migration, etc., in which all possible combinations of linked genes should be present at equal frequency. The situation is no more common than are such undisturbed populations. (18 Nov 1997) |
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