| SSC | single-strand conformational [analysis]; sister strand crossover; somatosensory cortex; standard sal... |
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| SSCP | single-stranded conformational polymorphism |
| MAP | Mean Arterial Pressure |
| CEM | computerized electroencephalographic map; conventional transmission electron microscope |
| ISM | information sources map [of UMLS]; International Society of Microbiologists; intersegmental muscle |
| MAP-KKK | MAP kinase kinase kinase |
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| SSCP | PCR)-single stand conformational polymorphism |
| PCR-SSCP | Polymerase chain reaction single strand conformational polymorphism |
| SSCP | Single Strand Conformational Polymorphism |
| SSCP | Single Strand Conformational Polymorphism analysis |
| conformational map | A graphical representation in which the dihedral angle of rotation about the alpha-carbon to carbonyl-carbon bond in polypeptides is plotted against the dihedral angle of rotation about the alpha-carbon to nitrogen bond. Synonym: conformational map. (05 Mar 2000) |
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| conformational change | <cell biology> Alteration in the shape usually the tertiary structure of a protein as a result of alteration in the environment pH, temperature, ionic strength) or the binding of a ligand (to a receptor) or binding of substrate (to an enzyme). (18 Nov 1997) |
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| polymorphism, single-stranded conformational | Variation occurring within a species in the conformation of denatured DNA fragments. These single-stranded DNA fragments are allowed to partially renature in a way that prevents the formation of double-stranded DNA. The fragments are run on polyacrylamide gels under various conditions to detect subtle changes in migration due to altered secondary structure. The resulting bands will align themselves if the fragments are the same, but will misalign if any point mutations are present. Sscps have been used in detecting mutations in various genes, such as oncogenes, tumour suppressor genes, and genes responsible for genetic diseases. (12 Dec 1998) |
| Haworth conformational formula | <biochemistry> Of cyclic sugars, for the pyranoses, these depict those shapes (conformations) on which none, one, or two ring-atoms lie outside the plane of the ring. If there are two such atoms para to each other, they can lie 1) on opposite sides of the plane (trans), giving chair forms, or 2) on the same side of the plane (cis), giving boat forms. For beta-d-ribopyranose, the two chair forms (4C1 and 1C4) are depicted. Similarly, there are six boat conformations. If the two (trans) exoplanar atoms are meta to each other, the conformation is a skew form; if the two atoms are ortho to each other, the conformation is a half-chair form. For the furanoses, the envelope conformations have one ring-atom exoplanar. If there are three adjacent, coplanar ring-atoms (the two exoplanar ring-atoms on opposite sides of the plane), the conformations are twist forms. (05 Mar 2000) |
| single stranded conformational polymorphism | Technique for detecting point mutations in genes by amplifying a region of genomic DNA (using asymmetric PCR) and running the resulting product on a high quality gel. Single base substitutions can alter the secondary structure of the fragment in the gel, producing a visible shift in its mobility. (18 Nov 1997) |
| macrorestriction map | <molecular biology> Map depicting the order of and distance between sites at which restriction enzymes cleave chromosomes. (09 Oct 1997) |
| map | 1. A representation of the surface of the earth, or of some portion of it, showing the relative position of the parts represented; usually on a flat surface. Also, such a representation of the celestial sphere, or of some part of it. There are five principal kinds of projection used in making maps: the orthographic, the stereographic, the globuar, the conical, and the cylindrical, or Mercator's projection. See Projection. 2. Anything which represents graphically a succession of events, states, or acts; as, an historical map. "Thus is his cheek the map of days outworn. <botany>" (Shak) Map lichen, a lichen (Lecidea geographica) growing on stones in curious maplike figures. Origin: From F. Mappe, in mappemonde map of the world, fr. L. Mappa napkin, signal cloth; a Punic word. Cf. Apron, Napkin, Nappe. Source: Websters Dictionary (01 Mar 1998) |
| map, contig | A map depicting the relative order of a linked library of small overlapping clones representing a complete chromosome segment. (12 Dec 1998) |
| map distance | The degree of separation of two loci on a linkage map, measured in morgans or centimorgans. (05 Mar 2000) |
| map-dot-fingerprint dystrophy | Fingerprint dystrophy accompanied by map-like patterns and microcystic epithelial inclusions. (05 Mar 2000) |
| MAP kinase | Mitogen activated protein kinases. (ERKs: externally regulated kinases) Serine threonine kinases that are activated when quiescent cells are treated with mitogens and therefore potentially transmit signal for entry into cell cycle. One target is trancription factor p62TCF. MAP kinase itself can be phosphorylated by MAP kinase kinase and this may in turn be controlled by RAF 1. Confusingly, do phosphorylate microtubule-associated proteins. (18 Nov 1997) |
| MAP kinase kinase kinase | <enzyme> From pc12 cells; reactivates map kinase kinase inactivated by protein phosphatase 2a by phosphorylation of serine residues; tak1 (tgf-beta-activated kinase 1) is a member of the mapkkk family; genbank ab006787 (mouse) Registry number: EC 2.7.10.- Synonym: mapkkk, tak1 mapkkk, ask1 (kinase), apoptosis signal-regulating kinase 1 (26 Jun 1999) |
| map, linkage | A map of the genes on a chromosome based on linkage analysis. A linkage map does not show the physical distances between genes but rather their relative positions, as determined by how often two gene loci are inherited together. The closer two genes are (the more tightly they are linked), the more often they will be inherited together. Linkage distance is measured in centimorgans (cm). (12 Dec 1998) |
| map, physical | A map of the locations of identifiable landmarks on chromosomes. Physical distance is measured in base pairs. The physical map differs from the genetic map which is based purely on genetic linkage data. In the human genome, the lowest-resolution physical map is the banding patterns of the 24 different chromosomes. The highest-resolution physical map is the complete nucleotide sequence of all chromosomes, a future goal. (12 Dec 1998) |
| genetic map | <genetics> A map of the relative positions of genetic loci on a chromosome, determined onthe basis of how often the loci are inherited together. Distance ismeasured in centimorgans (cM). (09 Oct 1997) |
| restriction map | <molecular biology> Map of DNA showing the position of sites recognised and cut by various restriction endonucleases. (12 Jan 1998) |
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