| CF | calcaneal fibular [ligament]; calcium leucovorin; calf blood flow; calibration factor; cancer-free; ... |
|---|---|
| F0, | F1 coupling factor |
| SSC | single-strand conformational [analysis]; sister strand crossover; somatosensory cortex; standard sal... |
| SSCP | single-stranded conformational polymorphism |
| H0 | null hypothesis |
| E-C coupling | Excitation-contraction coupling |
|---|---|
| (3)H | hypothesis that |
| CF1 | Coupling Factor 1 |
| ECC | Excitation-contraction coupling |
| CI | coupling interval |
| conformational change | <cell biology> Alteration in the shape usually the tertiary structure of a protein as a result of alteration in the environment pH, temperature, ionic strength) or the binding of a ligand (to a receptor) or binding of substrate (to an enzyme). (18 Nov 1997) |
|---|---|
| conformational map | A graphical representation in which the dihedral angle of rotation about the alpha-carbon to carbonyl-carbon bond in polypeptides is plotted against the dihedral angle of rotation about the alpha-carbon to nitrogen bond. Synonym: conformational map. (05 Mar 2000) |
| polymorphism, single-stranded conformational | Variation occurring within a species in the conformation of denatured DNA fragments. These single-stranded DNA fragments are allowed to partially renature in a way that prevents the formation of double-stranded DNA. The fragments are run on polyacrylamide gels under various conditions to detect subtle changes in migration due to altered secondary structure. The resulting bands will align themselves if the fragments are the same, but will misalign if any point mutations are present. Sscps have been used in detecting mutations in various genes, such as oncogenes, tumour suppressor genes, and genes responsible for genetic diseases. (12 Dec 1998) |
| Haworth conformational formula | <biochemistry> Of cyclic sugars, for the pyranoses, these depict those shapes (conformations) on which none, one, or two ring-atoms lie outside the plane of the ring. If there are two such atoms para to each other, they can lie 1) on opposite sides of the plane (trans), giving chair forms, or 2) on the same side of the plane (cis), giving boat forms. For beta-d-ribopyranose, the two chair forms (4C1 and 1C4) are depicted. Similarly, there are six boat conformations. If the two (trans) exoplanar atoms are meta to each other, the conformation is a skew form; if the two atoms are ortho to each other, the conformation is a half-chair form. For the furanoses, the envelope conformations have one ring-atom exoplanar. If there are three adjacent, coplanar ring-atoms (the two exoplanar ring-atoms on opposite sides of the plane), the conformations are twist forms. (05 Mar 2000) |
| single stranded conformational polymorphism | Technique for detecting point mutations in genes by amplifying a region of genomic DNA (using asymmetric PCR) and running the resulting product on a high quality gel. Single base substitutions can alter the secondary structure of the fragment in the gel, producing a visible shift in its mobility. (18 Nov 1997) |
| viscous mechanical coupling | <cell biology> Method by which adjacent cilia are synchronised in a field. Coupling is through the transmission of mechanical forces, rather than of a synchronising signal. (18 Nov 1997) |
| chemiosmotic coupling | The linking of ATP synthesis to electrontransfer by way of an electrochemical hydrogen cation gradient across amembrane. (09 Oct 1997) |
| metabolic coupling | <cell biology, molecular biology> Transfer between tissue cells in contact of low molecular weight metabolites such as nucleotides and amino acids. Transfer is via channels constituted by the connexons of gap junctions and does not involve exchange with the extracellular medium. First observed in cultures of animal cells in which radio labelled purines were transferred from wild type cells to mutants unable to utilise exogenous purines. (27 Jun 1999) |
| constant coupling | Where several premature beats are seen, the interval between each of them and the preceding normal beat is constant. Synonym: constant coupling. Variable coupling, where several extrasystoles are seen, the interval between each of them and the preceding sinus beat varies. (05 Mar 2000) |
| coupling | <biochemistry> The linking of two independent processes by a common intermediate, for example the coupling of electron transport to oxidative phosphorylation or the ATP ADP conversion to transport processes. (18 Nov 1997) |
| coupling defect | See: familial goiter. (05 Mar 2000) |
| coupling factor | Protein responsible for coupling transmembrane potentials to ATP synthesis in chloroplasts and mitochondria. Include ATP synthesising enzymes (F1 in mitochondrion), that can also act as ATP ases. (18 Nov 1997) |
| coupling factors | Proteins that restore phosphorylating ability to mitochondria that have lost it, i.e., have become "uncoupled" so that oxidation and electron transport no longer produces ATP. Usually termed coupling factor F1, F2, etc. Synonym: C factors. (05 Mar 2000) |
| coupling interval | The interval, usually expressed in hundredths of a second, between a normal sinus beat and the ensuing premature beat. (05 Mar 2000) |
| coupling phase | The physical relationship of two syntenic genes. If they are on the same chromosome, they are said to be "in coupling" or "in the cis phase"; if on opposite members of a chromosome pair, "in repulsion" or "in the trans phase." (05 Mar 2000) |
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