| MAD | Major Antigenic Determinant |
|---|---|
| AD | accident dispensary; acetate dialysis; active disease; acute dermatomyositis; addict, addiction; ade... |
| NAD | neutrophil actin dysfunction; new antigenic determinant; nicotinamide adenine dinucleotide; nicotini... |
| CMR | cardiomodulorespirography; cerebral metabolic rate; chief medical resident; common medical record; c... |
| HCPCS | Health Care Financing Administration common procedural collecting system; Health Care Financing Admi... |
| MAP | Multiple Antigenic Peptide |
|---|---|
| VAT | variant antigenic type |
| CRD | Cross Reacting Determinant |
| DDIA | double determinant immunoassay |
| MDM | minor determinant mixture |
| antigenic determinant | That part of an antigenic molecule against which a particular immune response is directed. For instance a tetra to penta peptide sequence in a protein, a tri to penta glycoside sequence in a polysaccharide. In the animal most antigens will present several or even many antigenic determinants simultaneously. See: hapten. (18 Nov 1997) |
|---|---|
| idiotypic antigenic determinant | The antigenic specificites defined by the unique sequences (idiotopes) of the antigen combining site. Thus anti-idiotype antibodies combine with those specific sequences, may block immunological reactions and may resemble the epitope to which the first antibody reacts. (18 Nov 1997) |
| genetic determinant | Any antigenic determinant or identifying characteristic, particularly those of allotypes. Synonym: genetic marker. (05 Mar 2000) |
| mathematical determinant | A formal algebraic operation on the terms of a square matrix of quantities, fundamental in solving multiple simultaneous equations and widely used in regression analysis, notably in epidemiology and quantitative genetics. If determinant is zero, the equations have no unambiguous solution. (05 Mar 2000) |
| determinant | 1. That which serves to determine; that which causes determination. 2. <mathematics> The sum of a series of products of several numbers, these products being formed according to certain specified laws; thus, the determinant of the nine numbers. Is a b' c'' a b'' c' + a' b'' c] a' b c'' + a'' b' c. The determinant is written by placing the numbers from which it is formed in a square between two vertical lines. The theory of determinants forms a very important branch of modern mathematics. 3. <logic> A mark or attribute, attached to the subject or predicate, narrowing the extent of both, but rendering them more definite and precise. Source: Websters Dictionary (01 Mar 1998) |
| determinant group | That part of an antigenic molecule against which a particular immune response is directed. For instance a tetra to penta peptide sequence in a protein, a tri to penta glycoside sequence in a polysaccharide. In the animal most antigens will present several or even many antigenic determinants simultaneously. See: hapten. (18 Nov 1997) |
| isoallotypic determinant | <genetics> Genetic determinant's that are both isotypic and allotypic in that they appear in all members of at least one subclass of immunoglobulin but only in some members of another subclass of the same species. (05 Mar 2000) |
| antigenic | Having the properties of an antigen (allergen). Synonym: allergenic, immunogenic. (05 Mar 2000) |
| antigenic competition | Competition that occurs when two different antigens, each of which can evoke an immunological response when inoculated alone, are mixed in equal quantities and inoculated together; the response may be to only one, that to the other being largely or entirely suppressed. (05 Mar 2000) |
| antigenic complex | A composite of different antigenic structures, such as a cell or a bacterium, or, by extension, a molecule containing two or more determinant groups of different antigenic specificities. (05 Mar 2000) |
| antigenic drift | <immunology> A change that occurs on the molecular level to effect a change in the antigenicity of a bacteria or virus. Antigenic drift occurs naturally and more rapidly in certain viruses (for example HIV). It is antigenic drift which complicates the development of an effective HIV (AIDS) vaccine. (27 Sep 1997) |
| antigenic modulation | Loss of detectable antigen from the surface of a cell after incubation with antibodies. This is one method in which some tumours escape detection by the immune system. Antigenic modulation of target antigens also reduces the therapeutic effectiveness of treatment by monoclonal antibodies. (12 Dec 1998) |
| antigenic shift | Mutation, i.e., sudden change in molecular structure of RNA/DNA in microorganisms, especially viruses, which produces new strains of the microorganism; hosts previously exposed to other strains have little or no acquired immunity to the new strain; antigenic shift is believed to be the explanation for the occurrence of strains of microorganisms, such as the influenza virus, associated with large scale epidemics. (05 Mar 2000) |
| antigenic switching | <immunology> The process by which a pathogenic microbe's genetic structure is altered tochange its surface antigens inorder to avoid being detected by the host's immune system. (09 Oct 1997) |
| antigenic variation | The phenomenon of changes in surface antigens in parasitic populations of Trypanosoma and Plasmodium (and some other parasitic protozoa) in order to escape immunological defense mechanisms. at least 100 different surface proteins have been found to appear and disappear during antigenic variation in a clone of trypanosomes. Each antigen is encoded in a separate gene. Antigenic variation is also known to occur in free living Protozoa and certain bacteria. (18 Nov 1997) |
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