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TT   1) Thrombin Time
  2) Transient Thyrotoxicosis
HT Hashimoto thyroiditis; hearing test; hearing threshold; heart; heart transplantation, heart transpla...
PTI pancreatic trypsin inhibitor; persistent tolerant infection; Pictorial Test of Intelligence; placent...
STT scaphotrapeziotrapezoid [joint]; serial thrombin time; skin temperature test
TAT tetanus antitoxin; thematic apperception test; thematic aptitude test; thrombin-antithrombin complex...
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AT III Anti-thrombin III
THR Thrombin
Th Thrombin
TAFI Thrombin Activatable Fibrinolysis Inhibitor
TAT Thrombin-antithrombin complex
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receptors, thrombin Cell surface proteins that specifically bind thrombin and trigger changes in the behaviour of blood cells. There are at least two types of thrombin receptors on platelets. The higher affinity receptors mediate the inhibition of stimulated adenylate cyclase, the secretion of acid hydrolases, and the activation of phospholipase a2. The lower affinity receptors are linked to phospholipase c and trigger platelet aggregation and exposure of fibrinogen binding sites. A human platelet thrombin receptor has been cloned and is a member of the family of peptide receptors. There are also thrombin receptors on endothelial cells and smooth muscle cells.
(12 Dec 1998)
human thrombin Thrombin obtained from human plasma by precipitation with suitable salts and organic solvents; same uses as thrombin.
(05 Mar 2000)
thrombin <enzyme> Protease (34 kD) generated in blood clotting that acts on fibrinogen to produce fibrin. Consists of two chains, A and B, linked by a disulphide bond. B chain has sequence homology with pancreatic serine proteases: cleaves at Arg Gly.
Thrombin is produced from prothrombin by the action either of the extrinsic system (tissue factor + phospholipid) or, more importantly, the intrinsic system (contact of blood with a foreign surface or connective tissue). Both extrinsic and intrinsic systems activate plasma factor X to form factor Xa which then, in conjunction with phospholipid (tissue derived or platelet factor 3) and factor V, catalyses the conversion.
(18 Nov 1997)
thrombin time Test of the conversion of fibrinogen to fibrin by thrombin in which clotting time of plasma mixed with a thrombin solution is measured. Time is prolonged by afibrinogenaemia, abnormal fibrinogen, or the presence of inhibitory substances, e.g., fibrin-fibrinogen degradation products, heparin. Reptilase, a thrombin-like enzyme unaffected by the presence of heparin, may be used in place of thrombin.
(12 Dec 1998)
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