| ¿µ¹® | enzyme-linked immunoabsorbent assay | ÇÑ±Û | È¿¼Ò¸é¿ªÃøÁ¤¹ý |
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| CAT | California Achievement Test; capillary agglutination test; catalase; cataract; catecholamine; Childr... |
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| CAP | camptodactyly-arthropathy-pericarditis [syndrome]; Canada Assistance Plan; capsule; captopril; catab... |
| CHL | Chinese hamster lung; chlorambucil; chloramphenicol |
| CMC | carboxymethylcellulose; care management continuity; carpometacarpal; cell-mediated cytolysis or cyto... |
| CSMP | chloramphenicol-sensitive microsomal protein |
| CAM | Chloramphenicol |
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| CAP | Chloramphenicol |
| CM | Chloramphenicol |
| CP | Chloramphenicol |
| CmR | Chloramphenicol resistance |
| chloramphenicol acetyltransferase assay | <investigation> A lab technique used to determine whether a given fragment of DNA has a promoter on it to encourage transcription to occur, by attaching the gene (called the CAT gene) which codes for the CAT enzyme to it, and observing whether the CAT enzyme is produced. (05 Jan 1998) |
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| chloramphenicol acetyltransferase | <enzyme> A bacterial enzyme that inactivates the antibiotic chloramphenicol by acetylation. Widely used as a reporter gene for examining the control of eucaryotic gene expression. Acronym: CAT (08 Mar 2000) |
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| chloramphenicol acetyltransferase gene | <molecular biology> A gene which codes for the CAT enzyme (the enzyme chloramphenicol acetyltransferase), which helps transfer an acetyl group (a CH3CO- group) to chloramphenicol, an antibiotic. The CAT gene is an important part of CAT assays. (09 Oct 1997) |
| chloramphenicol o-acetyltransferase | <enzyme> An enzyme that catalyses the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. Chemical name: Acetyl-CoA-chloramphenicol 3-O-acetyltransferase Registry number: EC 2.3.1.28 (12 Dec 1998) |
| chloramphenicol | <drug> A broad-spectrum antibiotic that inhibits bacterial protein synthesis in prokaryotes and in mitochondria and chloroplasts by acting on the 50S ribosomal subunit. It was first isolated from the fungus like bacterium Streptomyces venezuelae but is now produced synthetically. It is relatively toxic but finds wide application in medicine. (01 Dec 1998) |
| chloramphenicol 3'-O-phosphotransferase | <enzyme> Phosphorylates the 3'-oh position of chloramphenicol producing a metabolite which confers resistance to chloramphenicol when introduced into a chloramphenicol-sensitive host Registry number: EC 2.7.1.- Synonym: cpt protein, cpt gene product (26 Jun 1999) |
| chloramphenicol amidase | <enzyme> Mouse liver microsomal enzyme which cleaves dichloro-acetyl group from chloramphenicol Registry number: EC 3.5.1.- Synonym: chloramphenicol hydrolase. (26 Jun 1999) |
| chloramphenicol palmitate | <chemical> Same action and use as chloramphenicol. (05 Mar 2000) |
| chloramphenicol resistance | <microbiology, pharmacology> Nonsusceptibility of a bacterium to the action of chloramphenicol, a potent inhibitor of protein synthesis in the 50s ribosomal subunit where amino acids are added to nascent bacterial polypeptides. (12 Dec 1998) |
| chloramphenicol sodium succinate | <chemical> Chloramphenicol-alpha-(sodium succinate);the water-soluble sodium succinate derivative of chloramphenicol, suitable for parenteral administration; antibacterial activity, uses, and side effects are similar to those of the parent compound. (05 Mar 2000) |
| acetyl reduction assay | <investigation> A technique for measuring the nitrogen fixation activity in photosynthetic organisms. It uses a flame ionisation detector and a gas chromatography apparatus to determine the reduction of acetylene to ethylene by the enzyme nitrogenase. (06 May 1997) |
| Ames assay | <procedure> One of a number of procedures used to test substances for likely ability to cause cancer that combines the use of animal tissue to generate active metabolites of the substance with a test for mutagenicity in bacteria. (18 Nov 1997) |
| antibiotic assay | <investigation> A test to determine how sensitive a bacterial or fungal strain is to arange of antibiotics bymeasuring the microbes' ability to grow in astandard dilution of each chemical. (09 Oct 1997) |
| assay | <procedure> The determination of the amount of a particular constituent of a mixture or of the biological or pharmacological potency of a drug. (10 May 1997) |
| bandshift assay | <investigation> An assay for proteins, such as transcription factors, that bind specific DNA sequences. A labelled oligonucleotide corresponding to the recognition sequence is incubated with an appropriate nuclear protein extract and run on a nondenaturing acrylamide gel. Oligonucleotides that have been bound by proteins are retarded relative to those that are unbound. (18 Nov 1997) |
| biological assay | <technique> Once a pharmaceutical protein is isolated from the cells in which it was grown, researchers perform tests to measure the protein's biological activity. It must maintain a certain minimal level of biological activity to be used for animal or clinical testing or, later, for market. Researchers also test to confirm that the isolated protein is identical to the desired protein. (21 Mar 1998) |
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