| MPRD | cation-dependent mannose 6-phosphate receptor |
|---|---|
| ROC | Receptor Operated Channel |
| VSC | Voltage Sensitive Channel |
| Ca2+-blocker | calcium channel blocker |
| CCB | calcium channel blocker |
| KATP channel | ATP sensitive potassium channel |
|---|---|
| BK channel | K channel |
| Ca+2 | cation |
| NSC | Nonselective cation |
| NSCC | Nonselective cation channels |
channel-shoulder-pin attachment
| cation | <chemistry> A positively-charged ion. (16 Mar 1998) |
|---|---|
| cation-anion difference | <biochemistry> The difference between the sum of the measured cations and anions in the plasma or serum calculated as follows: (Na + K) -(Cl + HCO3) = < 20 mmol/l. Elevated values may occur in diabetic or lactic acidosis; normal or low values occur in bicarbonate-losing metabolic acidoses. Synonym: cation-anion difference. (05 Mar 2000) |
| cation exchange | The process by which a cation in a liquid phase exchanges with another cation present as the counter-ion of a negatively charged solid polymer (cation exchanger). A cation-exchange reaction in removal of the Na+ of a sodium chloride solution is RSO3-H+ + Na+ → RSO3-Na+ + H+ (R is the polymer, RSO3- is the cation exchanger); if this is combined with the anion-exchange reaction, NaCl is removed from the solution (desalting). Cation exchange may also be used chromatographically, to separate cations, and medicinally, to remove a cation; e.g., H+, from gastric contents, or Na+ and K+ in the intestine. See: anion exchange. (05 Mar 2000) |
| cation exchanger | An insoluble solid (usually a polystyrene or a polysaccharide) that has negatively charged radicals attached to it (e.g., -COO-, -SO3-), which can attract and hold cations that pass by in a moving solution if these are more attracted to the acid groups than the counter ion present. (05 Mar 2000) |
| cation-exchange resin | See: cation exchange, cation exchanger. (05 Mar 2000) |
| cation exchange resins | High molecular weight insoluble polymers which contain functional cationic groups that are capable of undergoing exchange reactions; used in various types of chromatography; also to treat hyperkalaemia. (12 Dec 1998) |
| cation exhange resin | <chemistry> An insoluble resin with fixed anionic groups which is used in chromatography to separate cationic molecules. (16 Mar 1998) |
| calcium channel | <physiology> A membrane channel that is specific for calcium. It is a voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorised as l, t, n, or p types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. (12 May 2002) |
| calcium channel agonist | <pharmacology> Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in vascular smooth muscle and/or cardiac muscle cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture. (12 Dec 1998) |
| calcium channel antagonist | <pharmacology> A class of drugs that act by selective inhibition of calcium ion influx through or across cell membranes or on the release and binding of calcium in intracellular pools. Calcium channel blockers are used primarily in the treatment of certain heart conditions and stroke. As they are inducers of vascular and other smooth muscle relaxation, they are also used in the treatment of hypertension and cerebrovascular spasms, as myocardial protective agents, and in the relaxation of uterine spasms. Synonym: calcium antagonist, calcium channel-blocker, slow channel-blocking agent. (12 May 2002) |
| calcium channel-blocker | <pharmacology> A class of drugs that act by selective inhibition of calcium ion influx through or across cell membranes or on the release and binding of calcium in intracellular pools. Calcium channel blockers are used primarily in the treatment of certain heart conditions and stroke. As they are inducers of vascular and other smooth muscle relaxation, they are also used in the treatment of hypertension and cerebrovascular spasms, as myocardial protective agents, and in the relaxation of uterine spasms. Synonym: calcium antagonist, calcium channel-blocker, slow channel-blocking agent. (12 May 2002) |
| gated ion channel | <physiology> Transmembrane proteins of excitable cells, that allow a flux of ions to pass only under defined circumstances. Channels may be either voltage gated, such as the sodium channel of neurons or ligand gated such as the acetylcholine receptor of cholinergic synapses. Channels tend to be relatively ion specific and allow fluxes of typically 1000 ions to pass in around 1ms, they are thus much faster at moving ions across a membrane than transport ATPases. (05 May 1997) |
| voltage-gated channel | A class of ion channel's that open and close in response to change in the electrical potential across the plasma membrane of the cell; voltage-gated Na+ c.'s are important for conducting action potential along nerve cell processes. (05 Mar 2000) |
| voltage gated ion channel | <physiology> A transmembrane ion channel whose permeability to ions is extremely sensitive to the transmembrane potential difference. These channels are essential for neuronal signal transmission and for intracellular signal transduction. See: sodium channel. (18 Nov 1997) |
| channel | A furrow, gutter, or groovelike passageway. See: canal. Origin: L. Canalis (05 Mar 2000) |
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