| mRNA | messenger Ribo-Nucleic Acid |
|---|---|
| H-mRNA | H-chain messenger ribonucleic acid |
| mRNA | messenger ribonucleic acid |
| pre-mRNA | precursor messenger ribonucleic acid |
| pre-mRNA | Precursor mRNA |
|---|---|
| mRNA | E-messenger RNA |
| mRNA | Messenger ribonucleic acid |
| NMD | Nonsense-mediated mRNA decay |
| mRNA | RNA |
| capping of mRNA | The process of adding a guanosine nucleotide to the 5'-end (the beginning) of an eukaryotic mRNA, then methylating (adding a -CH3 to) the guanosine. (09 Oct 1997) |
|---|
| capping | 1. Movement of cross linked cell surface material to the posterior region of a moving cell or to the perinuclear region. 2. The intracellular accumulation of intermediate filament protein in the pericentriolar region following microtubule disruption by colchicine. 3. The blocking of further addition of subunits by binding of a cap protein to the free end of a linear polymer such as actin. See: cap binding protein. (18 Nov 1997) |
|---|---|
| capping proteins | Proteins that bind to one end of actin filaments, preventing both addition and loss of actin monomers. (05 Mar 2000) |
| dental pulp capping | Application of a protective agent to an exposed pulp (direct capping) or the remaining thin layer of dentin over a nearly exposed pulp (indirect capping) in order to allow the pulp to recover and maintain its normal vitality and function. (12 Dec 1998) |
| direct pulp capping | A procedure for covering and protecting an exposed vital pulp. (05 Mar 2000) |
| immunologic capping | The process by which lymphoid cell surface immunoglobulin receptors, when exposed to bivalent anti-ig antibodies, collect in patches and form a cap at one pole of the cell. The caps may then be endocytosed or shed into the environment in the form of antigen-antibody complexes. Capping has also been induced by lectins and antigens. (12 Dec 1998) |
| indirect pulp capping | The application of a suspension of calcium hydroxide to a thin layer of dentin overlying the pulp (near exposure) in order to stimulate secondary dentin formation and protect the pulp. (05 Mar 2000) |
| alternative mRNA splicing | Splicing different exons in or out of messenger RNA to form different mRNA transcripts. (09 Oct 1997) |
| maternal mRNA | <molecular biology> Messenger RNA found in oocytes and early embryos that is derived from the maternal genome during oogenesis. See: masked messenger RNA. (18 Nov 1997) |
| mRNA | <molecular biology> Single stranded RNA molecule that specifies the amino acid sequence of one or more polypeptide chains. This information is translated during protein synthesis when ribosomes bind to the mRNA. In prokaryotes, mRNA is normally formed by splicing a large primary transcript from a DNA sequence and protein synthesis starts while the mRNA is still being synthesised. Prokaryote mRNAs are usually very short lived (average t 1/2 is 5mins.). In contrast, in eukaryotes the primary transcripts (HnRNA) are synthesised in the nucleus and they are extensively processed to give the mRNA that is exported to the cytoplasm where protein synthesis takes place. This processing includes the addition of a 5' 5' linked 7 methyl guanylate cap at the 5' end and a sequence of adenylate groups at the 3' end, the poly A tail, as well as the removal of any introns and the splicing together of exons, only 10% of HnRNA leaves the nucleus. Eukaryote mRNAs are comparatively long lived with a half life ranging from 30minutes to 24 hours. (27 Jun 1999) |
| mRNA (2'-O-methyladenosine-N6-)-methyltransferase | <enzyme> Involved in capping mRNA Registry number: EC 2.1.1.62 Synonym: mRNA n(6)-adenosine methyltransferase, mra methyltransferase, RNA(2'-o-methyladenosine-n(6)-)methyltransferase (26 Jun 1999) |
| mRNA(adenine-N6)-methyltransferase | <enzyme> Methylates mRNA at internal adenosine within the consensus sequence puac(a/c/u) Registry number: EC 2.1.1.- Synonym: mRNA-a-n6-methyltransferase, mRNA(adenine-n6)-methylase (26 Jun 1999) |
| mRNA (guanine(N7))-methyltransferase | <enzyme> Catalyses s-adenosyl-l-methionine and g(5')pppr-RNA to yield s-adenosyl-l-homocysteine and m(7)g(5')pppr-RNA; mRNA containing an n(7)-methylguanine cap Registry number: EC 2.1.1.56 Synonym: mRNA (guanine-7-)methyltransferase, mRNA(guanine-7-)methyltransferase, RNA (guanine-7) methyltransferase, abd1 gene product (26 Jun 1999) |
| mRNA guanylyltransferase | <enzyme> Catalyses transfer of GMP residue from GTP to 5' end of RNA to form cap structure identified as g(5')pppn; can also modify synthetic poly(a) and poly(g) to form m7g(5')pppan and m7g(5')pppgn; see also capping enzyme, vaccinia virus Registry number: EC 2.7.7.50 Synonym: RNA guanylyltransferase, m-RNA guanylyltransferase, GTP mRNA guanylyltransferase, mRNA capping enzyme, mRNA 5'-guanylyltransferase, cgt1 gene product, ceg1 gene product (26 Jun 1999) |
| mRNA maturase | <enzyme> Also potent endonuclease involved in recombination Registry number: EC 2.7.7.- Synonym: RNA, mitochondrial maturase, RNA maturase (26 Jun 1999) |
| mRNA (nucleoside-O(2'))-methyltransferase | <enzyme> Catalyses the reaction of s-adenosyl-l-methionine and m(7)g(5')pppr-RNA to yield s-adenosyl-l-homocysteine and m(7)g(5')ppprm-RNA; mRNA containing an o(2')-methylpurine cap Registry number: EC 2.1.1.57 (26 Jun 1999) |
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