| NTRC | National Toxins Research Center |
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| C. | 1) Candida C. Albicans C. Guillier... |
| BOT | botulinum toxin |
| BTX | botulinum toxin; brevetoxin |
| CT | Cholera toxins |
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| Stx1 | Shiga toxins 1 |
| BT | Botulinum A toxin |
| Botox | Botulinum A toxin |
| BoNT/A | Botulinum Neurotoxin A |
| botulinum toxins | <chemical> Toxins produced by clostridium botulinum. There are at least seven different substances, most being proteins. They have neuro-, entero-, and haemotoxic properties, are immunogenic, and include the most potent poisons known. The most commonly used apparently blocks release of acetylcholine at cholinergic synapses. Pharmacological action: anti-dyskinesia agents. (12 Dec 1998) |
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| botulinum antitoxin | An equine antitoxin against the toxins produced by the type a, b, or e strain of clostridium botulinum. Generally trivalent (abe) antitoxin is used. (12 Dec 1998) |
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| botulinum toxin | <protein> Neurotoxin (50 kD, 7 distinct serotypes) produced by certain strains of Clostridium botulinum. The bacterium produces the toxin as a complex with a haemagglutinin that prevents toxin inactivation in the gut. Proteolysis in the body results in cleavage into two fragments A and B. B binds to gangliosides and may stimulate the endocytosis of fragment A. See: synaptobrevin, tetanus toxin. (18 Nov 1997) |
| botulinum toxin type a | <chemical> A neurotoxin produced by clostridium botulinum. When consumed in contaminated food it can cause paralysis and death. In its purified form, it has been used in the treatment of blepharospasm and strabismus. Pharmacological action: neuromuscular agents. (12 Dec 1998) |
| clostridium botulinum | The aetiologic agent of botulism in man, wild ducks, and other waterfowl. It is also responsible for certain forms of forage poisoning in horses and cattle. The bacterium produces a powerful exotoxin that is resistant to proteolytic digestion. (12 Dec 1998) |
| bacterial toxins | Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases. (12 Dec 1998) |
| marine toxins | Toxic or poisonous substances elaborated by marine flora or fauna. They include also specific, characterised poisons or toxins for which there is no more specific heading, like those from poisonous fishes. Clupeotoxin, pahutoxin, prymnesin, scombrotoxin go here. (12 Dec 1998) |
| pertussis toxins | <chemical> Any of various biologically active proteins or toxins elaborated by bordetella pertussis that cause the symptoms of whooping cough. Some activate pancreatic islets, others inhibit the adenylate cyclase cascade and some cause lymphocytosis. Chemical name: Toxins, pertussis (12 Dec 1998) |
| streptococcal toxins | Group of haemolytic exotoxins released by Streptococci. _ haemolysin: 26-39 Kd (four types), forms ring like structures in membranes (see Streptolysin O). Lipid target unclear. _ haemolysin: a hot cold haemolysin with sphingomyelinase C activity. _ haemolysin: complex of two proteins (29 and 26 kD) that act synergistically, rabbit erythrocytes particularly sensitive. _ toxin: heat stable peptide (5 kD) with high proportion of hydrophobic amino acids. Seems to act in a detergent like manner (c.f. Subtilysin), but may form hydrophilic transmembrane pores by cooperative interaction with other _ toxin molecules. Leucocidin (Panton Valentine leucocidin): two components f (fast migration on CM cellulose column: 32 kD) and s (slow: 38 kD). Mode of action contentious. See: Streptococcus, streptolysins O and S, erythrogenic toxin. (18 Nov 1997) |
| toxins | Poisons produced by certain animals, plants, or bacteria. (12 Dec 1998) |
| lyngbya toxins | Toxins isolated from any species of the seaweed lyngbya or similar chemicals from other sources, including mollusks and micro-organisms. These have been found to be potent tumour promoters. (12 Dec 1998) |
Synonyms : Botulinum Toxin, Toxin, Botulinum, Toxins, Botulinum, Toxins, Clostridium botulinum, botulinum Toxins, Clostridium
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