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beta-lactam <pharmacology> A class of broad spectrum antibiotics that are structurally and pharmacologically related to the penicillins and cephalosporins.
(05 Mar 2000)
beta-lactam resistance Nonsusceptibility of an organism to the action of the beta-lactam antibiotics.
(12 Dec 1998)
beta-lactamase <enzyme> An enzyme produced by some bacteria, which causes the breakdown of the active form of some penicillin antibiotics, rendering them ineffective. It causes the hydrolysis of a beta-lactam (as penicillin to penicilloic acid); found in most strains of staphylococcus bacteria that are naturally resistant to penicillin.
Synonym: cephalosporinase, penicillinase.
(05 Mar 2000)
beta-lactamase inhibitor <pharmacology> Drugs such as clavulanic acid, which are used to inhibit bacterial beta-lactamases; often used with a penicillin or cephalosporin to overcome drug resistance.
(05 Mar 2000)
beta-lactamases <enzyme> Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
Chemical name: beta-Lactamhydrolase
Registry number: EC 3.5.2.6
(12 Dec 1998)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 3 ÆäÀÌÁö: 1
  • beta-Lactam Resistance - »õâ Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.
    Synonyms : beta Lactam Resistance, beta-Lactam Resistances
  • beta-Lactamases - »õâ Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
    Synonyms : beta-Lactamase, beta Lactamase, beta Lactamases
  • beta-Lactams - »õâ Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, and including monocyclic MONOBACTAMS. BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
    Synonyms : beta Lactams
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beta-lactamase penicillinase: enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibiotic
Ãâó: wordnet.princeton.edu/perl/webwn
beta-lactam A beta-lactam (β-lactam) is a lactam with a heteroatomic ring structure, consisting of three carbon atoms and one nitrogen atom (Fig. 1). The beta-lactam ring is part of several antibiotics, such as penicillin, which are therefore also called beta-lactam antibiotics. These antibiotics work by inhibiting the bacterial cell wall synthesis. This has a lethal effect on bacteria, especially on Gram-positive ones. ...
Ãâó: en.wikipedia.org/wiki/Beta-lactam
beta-lactam antibiotic Any of the antimicrobial drugs, such as penicillins or cephalosporins, that kill germs by interfering with the synthesis of bacterial cell walls. SYN: beta-lactam.
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beta-lactamase resistance The ability of microorganisms that produce the enzyme beta-lactamase, also called penicillinase, to resist the action of certain types of antibiotics, including some but not all forms of penicillin.
Ãâó:
beta-lactamase resistant penicillin Synthetic penicillins that resist the action of the enzyme beta-lactamase, produced by some microorganisms. Bacteria that produce the enzyme are not susceptible to the action of non?beta-lactamase resistant pe
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beta-lactam enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibiotic
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