| bcl-2 | <oncogene> Two variants of this oncogene are recognised. 1. Bcl-2: A proto-oncogene, activated by chromosome translocation in human B-cell lymphomas (hence bcl). Encodes a plasma membrane protein. The gene product inhibits programmed cell death (apoptosis) and is homologous with the worm gene ced 9. See: ced mutant. 2. Bcl-3: An oncogene associated with some cases of B-cell chronic lymphocytic leukaemias. The protein product contains seven ankyrin repeats very similar to those found in I kappa B. Seems to interfere with binding of 50 kD subunit of NF kappa B to DNA. (24 Mar 1998) |
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Synonyms : N-Bak Protein, bcl2 Homologous Antagonist-Killer Protein, bcl 2 Homologous Antagonist Killer Protein, bcl2 Homologous Antagonist Killer Protein
Synonyms : Bax Apoptosis Regulator Protein, Bax-beta Protein, Bax-delta Protein, bcl2-Associated X Protein, bcl2-Associated X Protein Isoform alpha, bcl2-Associated X Protein Isoform beta, bcl2-Associated X Protein Isoform delta, bcl2-Associated X Protein Isoform omega
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