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A O Apoptosis
ASK1 Apoptosis Signal-regulating Kinase 1
AIF Apoptosis inducing factor
IAP Inhibitor of Apoptosis
IAP Inhibitor of apoptosis protein
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  • JrId: 20858
    JournalTitle: an international journal on programmed cell death.
    MedAbbr: Apoptosis
    ISSN: 1360-8185
    ESSN:
    IsoAbbr: Apoptosis
    NlmId: 9712129
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apoptosis <cell biology> Programmed cell death as signalled by the nuclei in normally functioning human and animal cells when age or state of cell health and condition dictates.
An active process requiring metabolic activity by the dying cell, often characterised by cleavage of the DNA into fragments that give a so called laddering pattern on gels.
Cells that die by apoptosis do not usually elicit the inflammatory responses that are associated with necrosis, though the reasons are not clear.
Cancerous cells, however, are unable to experience the normal cell transduction or apoptosis-driven natural cell death process.
See: ced mutant, bcl.
(18 Nov 1997)
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  • Apoptosis - »õâ One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
    Synonyms : Apoptosis, Extrinsic Pathway, Apoptosis, Intrinsic Pathway, Programmed Cell Death, Type I, Apoptoses, Extrinsic Pathway, Apoptoses, Intrinsic Pathway, Extrinsic Pathway Apoptoses, Extrinsic Pathway Apoptosis, Intrinsic Pathway Apoptoses
  • Apoptosis Inducing Factor - »õâ A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.
    Synonyms : AIF Apoptosis Regulatory Protein, Apoptosis-Inducing Factor, Mitochondrial Apoptosis-Inducing Factor, Apoptosis-Inducing Factor, Mitochondrial, Mitochondrial Apoptosis Inducing Factor
  • Apoptosis Regulatory Proteins - »õâ A large group of proteins that control APOPTOSIS. This family of proteins includes many ONCOGENE PROTEINS as well as a wide variety of classes of INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS such as CASPASES.
    Synonyms : Apoptosis Inducing Proteins, Apoptosis Inhibiting Proteins, Death Factors (Apoptosis), Programmed Cell Death Proteins, Survival Factors (Apoptosis), Regulatory Proteins, Apoptosis
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apoptosis a type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal's survival
Ãâó: wordnet.princeton.edu/perl/webwn
apoptosis In biology, apoptosis (from the Greek words apo = from and ptosis = falling, pronounced ap-a-tow'-sis
Ãâó: en.wikipedia.org/wiki/Apoptosis
apoptosis Cellular suicide or programmed cell death. HIV may induce apoptosis in both infected and uninfected immune system cells. Normally when CD4 cells mature in the thymus gland, a small proportion of these cells are unable to distinguish self from nonself. Because these cells would otherwise attack the body's own tissues, they receive a biochemical signal from other cells that results in apoptosis. See Tumor Necrosis Factor.
Ãâó: www.amfar.org/cgi-bin/iowa/bridge.html
apoptosis [Greek, apo = away from + ptosis = fall] Programmed cell death which occurs in the development of many systems. eg between digits, nervous system
Ãâó: embryology.med.unsw.edu.au/Notes/Index/A.htm
apoptosis Programmed cell death (PCD); a process in which cellular DNA is degraded and the nucleus condensed; then cell is then devoured by neighboring cells or phagocytes.
Ãâó: depts.washington.edu/~genetics/courses/genet372/w2...
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apoptosis a type of cell death in which the cell uses specialized cellular machinery to kill itself
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