| APD | action potential duration; acute polycystic disease; advanced physical diagnosis; anteroposterior di... |
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| APD | antipsychotic drug |
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| AP | antipsychotic |
| antipsychotic | <pharmacology> A drug that is effective in the treatment of psychosis. Antipsychotic drugs (also called neuroleptic drugs and major tranquillisers) are a chemically diverse (including phenothiazines, thioxanthenes, butyrophenones, dibenzoxazepines, dibenzodiazepines and diphenylbutylpiperidines) but pharmacologically similar class of drugs used to treat schizophrenic, paranoid, schizoaffective and other psychotic disorders, acute delirium and dementia and manic episodes (during induction of lithium therapy), to control the movement disorders associated with Huntington disease, Gilles de la Tourette's syndrome and ballismus and to treat intractable hiccups and severe nausea and vomiting. Antipsychotic agents bind to dopamine, histamine, muscarinic cholinergic, a adrenergic and serotonin receptors. Blockade of dopaminergic transmission in various areas is thought to be responsible for their major effects: antipsychotic action by blockade in the mesolimbic and mesocortical areas, extrapyramidal side effects (dystonia, akathisia, parkinsonism and tardive dyskinesia) by blockade in the basal ganglia and antiemetic effects by blockade in the chemoreceptor trigger zone of the medulla. Sedation and autonomic side effects (orthostatic hypotension, blurred vision, dry mouth, nasal congestion and constipation) are caused by blockade of histamine, cholinergic and adrenergic receptors. (13 Nov 1997) |
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| antipsychotic agent | A functional category of neuroleptic drugs that are helpful in the treatment of psychosis and have a capacity to ameliorate thought disorders (e.g., chlorpromazine, haloperidol). See: neuroleptic. Synonym: antipsychotic, major tranquilliser. (05 Mar 2000) |
| antipsychotic agents | Agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in schizophrenia, senile dementia, transient psychosis following surgery or myocardial infarction, etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (12 Dec 1998) |
| antipsychotic agents, butyrophenone | Those butyrophenone derivatives used in the treatment of psychoses. (12 Dec 1998) |
| antipsychotic agents, phenothiazine | Phenothiazine derivatives used in the treatment of psychoses. (12 Dec 1998) |
Synonyms : Antipsychotic Drugs, Antipsychotics, Major Tranquilizers, Neuroleptic Agents, Neuroleptic Drugs, Tranquillizing Agents, Major, Agents, Antipsychotic, Agents, Major Tranquilizing, Agents, Major Tranquillizing, Agents, Neuroleptic, Drugs, Antipsychotic
| antipsychotic |
effective in the treatment of psychosis, or an agent that so acts. Antipsychotic agents (called also neuroleptic agents) are a chemically diverse (including phenothiazines, thioxanthenes, butyrophenones, dibenzoxazepines, dibenzodiazepines, dihydroindolones, and diphenylbutylpiperidines) but pharmacologically similar class of drugs used to treat schizophrenic, paranoid, schizoaffective, and other psychotic disorders; acute delirium and dementia and manic episodes (during induction of lithium therapy); to control the movement disorders associated with Huntington's chorea, Gilles de la Tourette's syndrome, and ballismus; and to treat intractable hiccups and severe nausea and vomiting. Antipsychotic agents bind to dopamine, histamine, muscarinic cholinergic, α-adrenergic, and serotonin receptors. Blockade of dopaminergic transmission in various areas is thought to be responsible for their major effects: antipsychotic action by blockade in the mesolimbic and mesocortical areas; extrapyramidal side effects (dystonia, akathisia, parkinsonism, and tardive dyskinesia) by blockade in the basal ganglia; and antiemetic effects by blockade in the chemoreceptor trigger zone of the medulla. Sedation and autonomic side effects (orthostatic hypotension, blurred vision, dry mouth, nasal congestion, and constipation) are caused by blockade of histamine, cholinergic, and adrenergic receptors.
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| antipsychotic | tranquilizer used to treat psychotic conditions when a calming effect is desired |
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| antipsychotic | tranquilizer used to treat psychotic conditions when a calming effect is desired |
| antipsychotic | tranquilizer used to treat psychotic conditions when a calming effect is desired |
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