| MAD | Major Antigenic Determinant |
|---|---|
| AD | accident dispensary; acetate dialysis; active disease; acute dermatomyositis; addict, addiction; ade... |
| NAD | neutrophil actin dysfunction; new antigenic determinant; nicotinamide adenine dinucleotide; nicotini... |
| CHESS | chemical shift selective |
| CSA | Canadian Standards Association; canavaninosuccinic acid; carbonyl salicylamide; cell surface antigen... |
| MAP | Multiple Antigenic Peptide |
|---|---|
| VAT | variant antigenic type |
| CSI | Chemical Shift Imaging |
| CHESS | Chemical shift selective |
| EMSA | Electromobility shift assays |
| antigenic shift | Mutation, i.e., sudden change in molecular structure of RNA/DNA in microorganisms, especially viruses, which produces new strains of the microorganism; hosts previously exposed to other strains have little or no acquired immunity to the new strain; antigenic shift is believed to be the explanation for the occurrence of strains of microorganisms, such as the influenza virus, associated with large scale epidemics. (05 Mar 2000) |
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| antigenic | Having the properties of an antigen (allergen). Synonym: allergenic, immunogenic. (05 Mar 2000) |
|---|---|
| antigenic competition | Competition that occurs when two different antigens, each of which can evoke an immunological response when inoculated alone, are mixed in equal quantities and inoculated together; the response may be to only one, that to the other being largely or entirely suppressed. (05 Mar 2000) |
| antigenic complex | A composite of different antigenic structures, such as a cell or a bacterium, or, by extension, a molecule containing two or more determinant groups of different antigenic specificities. (05 Mar 2000) |
| antigenic determinant | That part of an antigenic molecule against which a particular immune response is directed. For instance a tetra to penta peptide sequence in a protein, a tri to penta glycoside sequence in a polysaccharide. In the animal most antigens will present several or even many antigenic determinants simultaneously. See: hapten. (18 Nov 1997) |
| antigenic drift | <immunology> A change that occurs on the molecular level to effect a change in the antigenicity of a bacteria or virus. Antigenic drift occurs naturally and more rapidly in certain viruses (for example HIV). It is antigenic drift which complicates the development of an effective HIV (AIDS) vaccine. (27 Sep 1997) |
| antigenic modulation | Loss of detectable antigen from the surface of a cell after incubation with antibodies. This is one method in which some tumours escape detection by the immune system. Antigenic modulation of target antigens also reduces the therapeutic effectiveness of treatment by monoclonal antibodies. (12 Dec 1998) |
| antigenic switching | <immunology> The process by which a pathogenic microbe's genetic structure is altered tochange its surface antigens inorder to avoid being detected by the host's immune system. (09 Oct 1997) |
| antigenic variation | The phenomenon of changes in surface antigens in parasitic populations of Trypanosoma and Plasmodium (and some other parasitic protozoa) in order to escape immunological defense mechanisms. at least 100 different surface proteins have been found to appear and disappear during antigenic variation in a clone of trypanosomes. Each antigen is encoded in a separate gene. Antigenic variation is also known to occur in free living Protozoa and certain bacteria. (18 Nov 1997) |
| idiotypic antigenic determinant | The antigenic specificites defined by the unique sequences (idiotopes) of the antigen combining site. Thus anti-idiotype antibodies combine with those specific sequences, may block immunological reactions and may resemble the epitope to which the first antibody reacts. (18 Nov 1997) |
| antigen shift | Abrupt change in antigens expressed by a species or variety of organisms. Usually seen in microorganisms where the change may allow escape from immune recognition. Antigenic drift is a more gradual change. See: antigenic variation. (18 Nov 1997) |
| axis shift | Deflection of the electrical axis of the heart to the right or left of the normal. See: left axis deviation, right axis deviation, axis. Synonym: axis shift. (05 Mar 2000) |
| gas shift process | A process in which carbon monoxide and hydrogen react in the presence of a catalyst to form methane and water. (05 Dec 1998) |
| chemical shift | Dependence of the resonance frequency of a nucleus on the chemical binding of the atom or molecule in which it is contained. See: chemical shift artifact. (05 Mar 2000) |
| chemical shift artifact | In magnetic resonance imaging, a dark band caused by a biochemical difference in resonant frequency of adjacent regions rather than a true anatomic separation. (05 Mar 2000) |
| chloride shift | When CO2 enters the blood from the tissues, it passes into the red blood cell and is converted by carbonate dehydratase to bicarbonate (HCO3-); HCO3- ion passes out into the plasma while Cl- migrates into the red blood cell. Reverse changes occur in the lungs when CO2 is eliminated from the blood. Synonym: Hamburger's phenomenon. (05 Mar 2000) |
| antigenic shift |
which involves a major change in antigenicity, so that previously infected individuals possess little or no immunity to the shifted agent.
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