| GABA, gaba | gamma-aminobutyric acid |
|---|---|
| GABAT, GABA-T | gamma-aminobutyric acid transaminase |
| GABRA | gamma-aminobutyric acid alpha receptor |
| GVG | gamma-vinyl-gamma-aminobutyric acid |
| [(3)H]-GABA | 3)H]-gamma-aminobutyric acid |
|---|---|
| GABA | 3H-gamma aminobutyric acid |
| GABA-T | Gamma-Aminobutyric acid transaminase |
| GABAB | Gamma-Aminobutyric acid-B |
| GABAA | Gamma-aminobutyric acid Type A |
| aminobutyric acids | <chemistry> Aliphatic four carbon acids substituted in any position(s) with amino group(s). They are found in most living things. The best known is gaba. (12 Dec 1998) |
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| gamma aminobutyric acid | <biochemistry> An important amino acid which functions as the most prevalent inhibitory neurotransmitter in the central nervous system. Gamma aminobutyric acid works in partnership with a derivative of Vitamin B-6, pyridoxine, to cross from the axons to the dendrites through the synaptic cleft, in response to an electrical signal in the neuron and inhibits message transmission. This helps control the nerve cells from firing too fast, which would overload the system. The action of gamma aminobutyric acid decreases epileptic seizures and muscle spasms by inhibiting electrical signals in this manner. Studies have shown that the site of action in the brain of benzodiazepams, including Valium, is directly coupled to the brain receptor for gamma aminobutyric acid. Acronym: GABA (05 Jan 1998) |
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| gamma aminobutyric acid receptor | <physiology> Ligand gated chloride ion channel forming receptor opened by gamma aminobutyric acid. Two distinct types: A and B. A receptor: One of a family of neurotransmitter receptors with fast intrinsic ion channels that includes the glycine receptor and the nicotinic acetylcholine receptor. Distinct from another major receptor family, the muscarininc acetylcholine receptor and rhodopsin, with no intrinsic ion channel. The A receptor is specifically blocked by bicuculline. It consists of two pairs of protein chains forming an A2B2 complex, the A chains bind benzodiazepine and the B chains bind GABA. The 4 subunits are thought to form a tight group with the chloride channel in the middle. There is considerable similarity between the amino acid sequences of the receptor subunits and those of the nicotinic acetylcholine receptor suggesting that both receptors are derived from some evolutionary ancestor. See: amino acid receptor superfamily. B receptor: Brain receptor (80 kD) for the inhibitory neurotransmitter gamma amino butyric acid. Differs from the A receptor both in agonist specificity (baclofen is a specific agonist) and its effects on cells. It modulates intracellular calcium levels through a Go mediated effect on N type calcium channels and also lowers intracellular cAMP levels by an effect on adenylyl cyclase, thereby reducing the secretion of catecholamines. (05 Jan 1998) |
| d-aminobutyric acid | <enzyme> An enzyme catalyzing the reversible transfer of an amino group from d-aminobutyric acid to 2-oxoglutarate, thus forming a L-glutamic acid and succinate saemialdehyde. An important step in the catabolism of d-aminobutyric acid. (05 Mar 2000) |
Synonyms : Aminobutyric Acid, Acid, Aminobutyric, Acids, Aminobutyric
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