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  • multivalent allosteric inhibition
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  • polyvalent allosteric inhibition
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allosteric <biochemistry, chemistry> Of a binding site in a protein, usually an enzyme.
The catalytic function of an enzyme may be modified by interaction with small molecules, not only at the active site, but also at a spatially distinct (allosteric) site of different specificity.
Of a protein, a protein possessing such a site. An allosteric effector is a molecule bound at such a site that increases or decreases the activity of the enzyme.
(18 Nov 1997)
allosteric enzyme <biochemistry, chemistry> A regulatory enzyme whose activity is modified by the noncovalent binding of a particular metabolite at a site (the allosteric site) other than the active site.
(09 Oct 1997)
allosteric site A specific site on a multi-subunit enzyme or other protein that is not the substrate binding site, but that when reversibly bound by an effector, induces a conformational change in the protein, altering its catalytic or binding properties.
(12 Dec 1998)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 2 ÆäÀÌÁö: 1
  • Allosteric Regulation - »õâ
    Synonyms : Regulation, Allosteric, Allosteric Regulations, Regulations, Allosteric
  • Allosteric Site - »õâ A site on an enzyme which upon binding of a modulator, causes the protein to undergo a conformational change that may alter the catalytic or binding properties of the enzyme.
    Synonyms : Allosteric Sites, Site, Allosteric, Sites, Allosteric
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allosteric activation increase in enzyme activity by binding of an effector at an allosteric site that causes at the catalytic site either increased binding affinity of the enzyme for the substrate or increased rate of catalytic turnover.
Ãâó: www.merckmedicus.com/pp/us/hcp/thcp_dorlands_conte...
allosteric A term to describe proteins that have two or more receptor sites, one of which (the active site) binds the principal substrate, whereas the other(s) bind(s) effector molecules that can influence its biological activity.
Ãâó: www.nature.com/nrn/journal/v2/n4/glossary/nrn0401_...
allosteric Characteristic of some proteins, especially enzymes, in which a compound combines with a site on the protein other than the active site, resulting in a change in confirmation at the active site.
Ãâó: www.pestmanagement.co.uk/lib/glossary/glossary_a.s...
allosteric site A specific receptor site of an enzyme molecule remote from the active site. Molecules bind to the allosteric site and change the shape of the active site, making it either more or less receptive to the substrate.
Ãâó: xray.bmc.uu.se/~kenth/bioinfo/glossary.html
allosteric Alteration of a protein conformation resulting in alteration of function (eg non-competitive receptor inhibition).
Ãâó: www.uni-graz.at/~binder/science/abc.html
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